Compile Data Set for Download or QSAR
maximum 50k data
Found 44 Enz. Inhib. hit(s) with all data for entry = 50031524
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314754(CHEMBL1088784 | N-(5-benzyl-4-phenyl-1,3-thiazol-2...)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314752(CHEMBL1092385 | N-[2-({[1-Phenyl-3-(trifluoromethy...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314753(6-Ethoxy-N-[2-({[1-phenyl-3-(trifluoromethyl)-1Hpy...)
Affinity DataIC50:  25nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314738(CHEMBL1089182 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314730(CHEMBL1089874 | N-(2-(4-ethoxybenzamido)ethyl)-1-p...)
Affinity DataIC50:  33nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314737(1-(3-Ethoxyphenyl)-N-(2-{[(4-ethoxyphenyl)carbonyl...)
Affinity DataIC50:  44nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314752(CHEMBL1092385 | N-[2-({[1-Phenyl-3-(trifluoromethy...)
Affinity DataIC50:  44nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314751(6-Chloro-N-[2-({[1-phenyl-3-(trifluoromethyl)-1Hpy...)
Affinity DataIC50:  49nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314730(CHEMBL1089874 | N-(2-(4-ethoxybenzamido)ethyl)-1-p...)
Affinity DataIC50:  77nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314749(1-Phenyl-N-[2-({[4-(1H-pyrazol-1-yl)phenyl]carbony...)
Affinity DataIC50:  79nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314753(6-Ethoxy-N-[2-({[1-phenyl-3-(trifluoromethyl)-1Hpy...)
Affinity DataIC50:  87nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314738(CHEMBL1089182 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Affinity DataIC50:  91nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314734(1-(4-Chlorophenyl)-N-(2-{[(4-ethoxyphenyl)carbonyl...)
Affinity DataIC50:  94nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314741(CHEMBL1089208 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Affinity DataIC50:  98nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314736(1-(4-Ethoxyphenyl)-N-(2-{[(4-ethoxyphenyl)carbonyl...)
Affinity DataIC50:  140nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314733(1-Cyclohexyl-N-(2-{[(4-ethoxyphenyl)carbonyl]amino...)
Affinity DataIC50:  220nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314732(CHEMBL1089875 | N-(2-(4-Ethoxybenzamido)ethyl)-3-m...)
Affinity DataIC50:  260nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314751(6-Chloro-N-[2-({[1-phenyl-3-(trifluoromethyl)-1Hpy...)
Affinity DataIC50:  370nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314736(1-(4-Ethoxyphenyl)-N-(2-{[(4-ethoxyphenyl)carbonyl...)
Affinity DataIC50:  380nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314749(1-Phenyl-N-[2-({[4-(1H-pyrazol-1-yl)phenyl]carbony...)
Affinity DataIC50:  400nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314737(1-(3-Ethoxyphenyl)-N-(2-{[(4-ethoxyphenyl)carbonyl...)
Affinity DataIC50:  600nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314741(CHEMBL1089208 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Affinity DataIC50:  610nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314732(CHEMBL1089875 | N-(2-(4-Ethoxybenzamido)ethyl)-3-m...)
Affinity DataIC50:  650nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314733(1-Cyclohexyl-N-(2-{[(4-ethoxyphenyl)carbonyl]amino...)
Affinity DataIC50:  650nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314755(5-benzyl-N-(2-(4-ethoxybenzamido)ethyl)-4-phenylth...)
Affinity DataIC50:  700nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314735(1-Benzyl-N-(2-{[(4-ethoxyphenyl)carbonyl]amino}-et...)
Affinity DataIC50:  770nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314735(1-Benzyl-N-(2-{[(4-ethoxyphenyl)carbonyl]amino}-et...)
Affinity DataIC50:  790nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314731(CHEMBL1089304 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314750(5-Chloro-N-[2-({[1-phenyl-3-(trifluoromethyl)-1Hpy...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314750(5-Chloro-N-[2-({[1-phenyl-3-(trifluoromethyl)-1Hpy...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314734(1-(4-Chlorophenyl)-N-(2-{[(4-ethoxyphenyl)carbonyl...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314740(CHEMBL1089507 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314731(CHEMBL1089304 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314746(CHEMBL1091906 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314740(CHEMBL1089507 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314748(CHEMBL1091721 | N-(2-{[(3-Ethoxyphenyl)carbonyl]am...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314748(CHEMBL1091721 | N-(2-{[(3-Ethoxyphenyl)carbonyl]am...)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314747(CHEMBL1091905 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314739(CHEMBL1089508 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314742((R)-N-(2-{[(4-Ethoxyphenyl)carbonyl]amino}-3-hydro...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314743((S)-N-(2-{[(4-Ethoxyphenyl)carbonyl]amino}-3-hydro...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314744((S)-N-[2-{[(4-Ethoxyphenyl)carbonyl]amino}-1-(hydr...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314739(CHEMBL1089508 | N-(2-{[(4-Ethoxyphenyl)carbonyl]am...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314745((R)-N-[2-{[(4-Ethoxyphenyl)carbonyl]amino}-1-(hydr...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed