Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 50022572
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataKi:  3nMAssay Description:Binding affinity to recombinant N-terminal truncated MK2 (45 to 371 residues) (unknown origin) expressed in Escherichia coli assessed as inhibition c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMAP kinase-activated protein kinase 5(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant PRAK (unknown origin) expressed in Escherichia coli using KKKALSRQLSVAA as substrate incubated for 1 hr followed by substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of recombinant N-terminal truncated MK2 (45 to 371 residues) (unknown origin) expressed in Escherichia coli using KKKALSRQLSVAA as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataKd:  5.90nMAssay Description:Binding affinity to recombinant N-terminal truncated MK2 (45 to 371 residues) (unknown origin) expressed in Escherichia coli assessed as dissociation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMAP kinase-activated protein kinase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 53nMAssay Description:Inhibition of recombinant MK3 (unknown origin) expressed in Escherichia coli using KKKALSRQLSVAA as substrate incubated for 1 hr followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 60nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase 17A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 71nMAssay Description:Inhibition of DRAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Mer(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 76nMAssay Description:Inhibition of Mer (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 88nMAssay Description:Inhibition of Pim1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase BRSK2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 90nMAssay Description:Inhibition of BrSK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 148nMAssay Description:Inhibition of recombinant MNK2 (unknown origin) using KKKALSRQLSVAA as substrate incubated for 1 hr followed by substrate addition in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase BRSK1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 187nMAssay Description:Inhibition of BrSK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 354nMAssay Description:Inhibition of CDK1/cycB (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 428nMAssay Description:Inhibition of Axl (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 528nMAssay Description:Inhibition of PhKgamma2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 590nMAssay Description:Inhibition of RIPK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 902nMAssay Description:Inhibition of CDK5/p35 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of recombinant MNK1 (unknown origin) expressed in Escherichia coli using KKKALSRQLSVAA as substrate incubated for 1 hr followed by substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed