Compile Data Set for Download or QSAR
Report error Found 39 Enz. Inhib. hit(s) with all data for entry = 50031590
TargetAurora kinase A(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315839BDBM50315839(4-methyl-N-(3-(2-(6-methyl-5-(2-(thiophen-2-yl)ace...)
Affinity DataIC50: 13nMAssay Description:Inhibition of hexahistidine tagged recombinant Aurora A expressed in Hi-5 cells assessed as ATP remaining after 2 hrs by bioluminescenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315848BDBM50315848(N-(6-methyl-3-styryl-1H-indazol-5-yl)-2-(thiophen-...)
Affinity DataIC50: 17nMAssay Description:Inhibition of hexahistidine tagged recombinant Aurora A expressed in Hi-5 cells assessed as ATP remaining after 2 hrs by bioluminescenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315850BDBM50315850(N-(6-methyl-3-styryl-1H-indazol-5-yl)-2-phenylacet...)
Affinity DataIC50: 19nMAssay Description:Inhibition of hexahistidine tagged recombinant Aurora A expressed in Hi-5 cells assessed as ATP remaining after 2 hrs by bioluminescenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315851BDBM50315851(2-phenyl-N-(3-styryl-1H-indazol-5-yl)acetamide | C...)
Affinity DataIC50: 22nMAssay Description:Inhibition of hexahistidine tagged recombinant Aurora A expressed in Hi-5 cells assessed as ATP remaining after 2 hrs by bioluminescenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315837BDBM50315837(N-(3-(3-((4-methylpiperazin-1-yl)methyl)styryl)-1H...)
Affinity DataIC50: 26nMAssay Description:Inhibition of GST tagged recombinant Aurora B expressed in Hi-5 cells after 1 hr by TRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315834BDBM50315834(1-phenyl-N-(3-styryl-1H-indazol-5-yl)methanesulfon...)
Affinity DataIC50: 31nMAssay Description:Inhibition of GST tagged recombinant Aurora B expressed in Hi-5 cells after 1 hr by TRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315832BDBM50315832(3-methyl-5-(4-methyl-3-(3-((4-methylpiperazin-1-yl...)
Affinity DataIC50: 31nMAssay Description:Inhibition of GST tagged recombinant Aurora B expressed in Hi-5 cells after 1 hr by TRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315834BDBM50315834(1-phenyl-N-(3-styryl-1H-indazol-5-yl)methanesulfon...)
Affinity DataIC50: 35nMAssay Description:Inhibition of hexahistidine tagged recombinant Aurora A expressed in Hi-5 cells assessed as ATP remaining after 2 hrs by bioluminescenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315837BDBM50315837(N-(3-(3-((4-methylpiperazin-1-yl)methyl)styryl)-1H...)
Affinity DataIC50: 35nMAssay Description:Inhibition of hexahistidine tagged recombinant Aurora A expressed in Hi-5 cells assessed as ATP remaining after 2 hrs by bioluminescenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315835BDBM50315835(2-(2,5-dimethoxyphenyl)-N-(6-methyl-3-styryl-1H-in...)
Affinity DataIC50: 42nMAssay Description:Inhibition of hexahistidine tagged recombinant Aurora A expressed in Hi-5 cells assessed as ATP remaining after 2 hrs by bioluminescenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315846BDBM50315846(5-(pyridin-4-yl)-6-(pyrrolidin-1-yl)-3-styryl-1H-i...)
Affinity DataIC50: 46nMAssay Description:Inhibition of GST tagged recombinant Aurora B expressed in Hi-5 cells after 1 hr by TRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315839BDBM50315839(4-methyl-N-(3-(2-(6-methyl-5-(2-(thiophen-2-yl)ace...)
Affinity DataIC50: 46nMAssay Description:Inhibition of GST tagged recombinant Aurora B expressed in Hi-5 cells after 1 hr by TRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315848BDBM50315848(N-(6-methyl-3-styryl-1H-indazol-5-yl)-2-(thiophen-...)
Affinity DataIC50: 47nMAssay Description:Inhibition of GST tagged recombinant Aurora B expressed in Hi-5 cells after 1 hr by TRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315833BDBM50315833(4-methyl-3-(3-((4-methylpiperazin-1-yl)methyl)styr...)
Affinity DataIC50: 59nMAssay Description:Inhibition of GST tagged recombinant Aurora B expressed in Hi-5 cells after 1 hr by TRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315841BDBM50315841(4-methyl-N-(3-(2-(5-(methylsulfonamido)-6-(pyrroli...)
Affinity DataIC50: 62nMAssay Description:Inhibition of GST tagged recombinant Aurora B expressed in Hi-5 cells after 1 hr by TRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315838BDBM50315838(N-(6-methyl-3-(3-((4-methylpiperazin-1-yl)methyl)s...)
Affinity DataIC50: 79nMAssay Description:Inhibition of hexahistidine tagged recombinant Aurora A expressed in Hi-5 cells assessed as ATP remaining after 2 hrs by bioluminescenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315842BDBM50315842(6-(pyrrolidin-1-yl)-3-styryl-1H-indazol-5-amine | ...)
Affinity DataIC50: 81nMAssay Description:Inhibition of GST tagged recombinant Aurora B expressed in Hi-5 cells after 1 hr by TRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315840BDBM50315840(N-(6-(pyrrolidin-1-yl)-3-styryl-1H-indazol-5-yl)-2...)
Affinity DataIC50: 91nMAssay Description:Inhibition of hexahistidine tagged recombinant Aurora A expressed in Hi-5 cells assessed as ATP remaining after 2 hrs by bioluminescenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315836BDBM50315836(N-(4-methyl-3-(3-((4-methylpiperazin-1-yl)methyl)s...)
Affinity DataIC50: 99nMAssay Description:Inhibition of GST tagged recombinant Aurora B expressed in Hi-5 cells after 1 hr by TRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315847BDBM50315847(N-(6-methyl-3-(phenylethynyl)-1H-indazol-5-yl)-2-(...)
Affinity DataIC50: 110nMAssay Description:Inhibition of GST tagged recombinant Aurora B expressed in Hi-5 cells after 1 hr by TRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315840BDBM50315840(N-(6-(pyrrolidin-1-yl)-3-styryl-1H-indazol-5-yl)-2...)
Affinity DataIC50: 110nMAssay Description:Inhibition of GST tagged recombinant Aurora B expressed in Hi-5 cells after 1 hr by TRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315843BDBM50315843(5-nitro-6-(pyrrolidin-1-yl)-3-styryl-1H-indazole |...)
Affinity DataIC50: 110nMAssay Description:Inhibition of GST tagged recombinant Aurora B expressed in Hi-5 cells after 1 hr by TRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315844BDBM50315844(N-(pyridin-2-ylmethyl)-6-(pyrrolidin-1-yl)-3-styry...)
Affinity DataIC50: 130nMAssay Description:Inhibition of GST tagged recombinant Aurora B expressed in Hi-5 cells after 1 hr by TRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315838BDBM50315838(N-(6-methyl-3-(3-((4-methylpiperazin-1-yl)methyl)s...)
Affinity DataIC50: 130nMAssay Description:Inhibition of GST tagged recombinant Aurora B expressed in Hi-5 cells after 1 hr by TRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315841BDBM50315841(4-methyl-N-(3-(2-(5-(methylsulfonamido)-6-(pyrroli...)
Affinity DataIC50: 140nMAssay Description:Inhibition of hexahistidine tagged recombinant Aurora A expressed in Hi-5 cells assessed as ATP remaining after 2 hrs by bioluminescenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315846BDBM50315846(5-(pyridin-4-yl)-6-(pyrrolidin-1-yl)-3-styryl-1H-i...)
Affinity DataIC50: 160nMAssay Description:Inhibition of hexahistidine tagged recombinant Aurora A expressed in Hi-5 cells assessed as ATP remaining after 2 hrs by bioluminescenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315835BDBM50315835(2-(2,5-dimethoxyphenyl)-N-(6-methyl-3-styryl-1H-in...)
Affinity DataIC50: 180nMAssay Description:Inhibition of GST tagged recombinant Aurora B expressed in Hi-5 cells after 1 hr by TRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315842BDBM50315842(6-(pyrrolidin-1-yl)-3-styryl-1H-indazol-5-amine | ...)
Affinity DataIC50: 200nMAssay Description:Inhibition of hexahistidine tagged recombinant Aurora A expressed in Hi-5 cells assessed as ATP remaining after 2 hrs by bioluminescenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315843BDBM50315843(5-nitro-6-(pyrrolidin-1-yl)-3-styryl-1H-indazole |...)
Affinity DataIC50: 240nMAssay Description:Inhibition of hexahistidine tagged recombinant Aurora A expressed in Hi-5 cells assessed as ATP remaining after 2 hrs by bioluminescenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315847BDBM50315847(N-(6-methyl-3-(phenylethynyl)-1H-indazol-5-yl)-2-(...)
Affinity DataIC50: 240nMAssay Description:Inhibition of hexahistidine tagged recombinant Aurora A expressed in Hi-5 cells assessed as ATP remaining after 2 hrs by bioluminescenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315833BDBM50315833(4-methyl-3-(3-((4-methylpiperazin-1-yl)methyl)styr...)
Affinity DataIC50: 280nMAssay Description:Inhibition of hexahistidine tagged recombinant Aurora A expressed in Hi-5 cells assessed as ATP remaining after 2 hrs by bioluminescenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315832BDBM50315832(3-methyl-5-(4-methyl-3-(3-((4-methylpiperazin-1-yl...)
Affinity DataIC50: 350nMAssay Description:Inhibition of hexahistidine tagged recombinant Aurora A expressed in Hi-5 cells assessed as ATP remaining after 2 hrs by bioluminescenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315844BDBM50315844(N-(pyridin-2-ylmethyl)-6-(pyrrolidin-1-yl)-3-styry...)
Affinity DataIC50: 620nMAssay Description:Inhibition of hexahistidine tagged recombinant Aurora A expressed in Hi-5 cells assessed as ATP remaining after 2 hrs by bioluminescenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315849BDBM50315849(2-phenyl-N-(3-(2-phenylcyclopropyl)-1H-indazol-5-y...)
Affinity DataIC50: 640nMAssay Description:Inhibition of hexahistidine tagged recombinant Aurora A expressed in Hi-5 cells assessed as ATP remaining after 2 hrs by bioluminescenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315845BDBM50315845(6-(4-methylpiperazin-1-yl)-N-(pyridin-2-ylmethyl)-...)
Affinity DataIC50: 810nMAssay Description:Inhibition of GST tagged recombinant Aurora B expressed in Hi-5 cells after 1 hr by TRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315849BDBM50315849(2-phenyl-N-(3-(2-phenylcyclopropyl)-1H-indazol-5-y...)
Affinity DataIC50: 1.64E+3nMAssay Description:Inhibition of GST tagged recombinant Aurora B expressed in Hi-5 cells after 1 hr by TRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315852BDBM50315852(N-(3-phenethyl-1H-indazol-5-yl)-2-phenylacetamide ...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of hexahistidine tagged recombinant Aurora A expressed in Hi-5 cells assessed as ATP remaining after 2 hrs by bioluminescenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315836BDBM50315836(N-(4-methyl-3-(3-((4-methylpiperazin-1-yl)methyl)s...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of hexahistidine tagged recombinant Aurora A expressed in Hi-5 cells assessed as ATP remaining after 2 hrs by bioluminescenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
S*Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315845BDBM50315845(6-(4-methylpiperazin-1-yl)-N-(pyridin-2-ylmethyl)-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of hexahistidine tagged recombinant Aurora A expressed in Hi-5 cells assessed as ATP remaining after 2 hrs by bioluminescenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed