Compile Data Set for Download or QSAR
maximum 50k data
Found 122 Enz. Inhib. hit(s) with all data for entry = 50039146
TargetDNA topoisomerase 1(Rattus norvegicus)
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM7459(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50:  660nMAssay Description:Inhibition of rat liver DNA topoisomerase 1 preincubated before addition of DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Rattus norvegicus)
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM7459(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of rat liver DNA topoisomerase 1 treated simultaneously with DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317521(Aesculioside IIIa | CHEMBL1094690)
Affinity DataIC50:  2.38E+4nMAssay Description:Inhibition of human DNA topoisomerase 1 at free enzyme stateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317518(Aesculioside IId | CHEMBL1095016)
Affinity DataIC50:  2.38E+4nMAssay Description:Inhibition of human DNA topoisomerase 1 at free enzyme stateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317518(Aesculioside IId | CHEMBL1095016)
Affinity DataIC50:  2.38E+4nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317519(Aesculioside IIc | CHEMBL1095014)
Affinity DataIC50:  2.38E+4nMAssay Description:Inhibition of human DNA topoisomerase 1 at free enzyme stateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317503(Aesculioside IVc | CHEMBL1094679)
Affinity DataIC50:  2.38E+4nMAssay Description:Inhibition of human DNA topoisomerase 1 at free enzyme stateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317527(Aesculioside IIIb | CHEMBL1094683)
Affinity DataIC50:  2.38E+4nMAssay Description:Inhibition of human DNA topoisomerase 1 at free enzyme stateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317511(Aesculioside IVb | CHEMBL1094681)
Affinity DataIC50:  2.38E+4nMAssay Description:Inhibition of human DNA topoisomerase 1 at free enzyme stateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317510(AesculiosideIV-23C1 | CHEMBL1094358)
Affinity DataIC50:  2.38E+4nMAssay Description:Inhibition of human DNA topoisomerase 1 at free enzyme stateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317508(Aesculioside IV-23E | CHEMBL1094674)
Affinity DataIC50:  2.38E+4nMAssay Description:Inhibition of human DNA topoisomerase 1 at free enzyme stateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317507(Aesculioside IV-23D1 | CHEMBL1094675)
Affinity DataIC50:  2.38E+4nMAssay Description:Inhibition of human DNA topoisomerase 1 at free enzyme stateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317505(Aesculioside IVa | CHEMBL1094677)
Affinity DataIC50:  2.38E+4nMAssay Description:Inhibition of human DNA topoisomerase 1 at free enzyme stateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317507(Aesculioside IV-23D1 | CHEMBL1094675)
Affinity DataIC50:  2.71E+4nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317508(Aesculioside IV-23E | CHEMBL1094674)
Affinity DataIC50:  3.27E+4nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317511(Aesculioside IVb | CHEMBL1094681)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317514(Aesculioside IIIe | CHEMBL1095027)
Affinity DataIC50:  4.51E+4nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317516(Aesculioside IIId | CHEMBL1095025)
Affinity DataIC50:  4.86E+4nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317503(Aesculioside IVc | CHEMBL1094679)
Affinity DataIC50:  4.97E+4nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317505(Aesculioside IVa | CHEMBL1094677)
Affinity DataIC50:  5.18E+4nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317510(AesculiosideIV-23C1 | CHEMBL1094358)
Affinity DataIC50:  5.30E+4nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317515(Aesculioside IIIf | CHEMBL1095026)
Affinity DataIC50:  5.37E+4nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317532(Aesculioside IIa | CHEMBL1094691)
Affinity DataIC50:  1.09E+5nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317519(Aesculioside IIc | CHEMBL1095014)
Affinity DataIC50:  1.11E+5nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317521(Aesculioside IIIa | CHEMBL1094690)
Affinity DataIC50:  1.19E+5nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317512(Aesculioside IIIc | CHEMBL1095341)
Affinity DataIC50:  1.32E+5nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317527(Aesculioside IIIb | CHEMBL1094683)
Affinity DataIC50:  1.60E+5nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317534(CHEMBL1096728 | Damara-20(22), 24-dien-3, 6, 12-tr...)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of human DNA topoisomerase 2-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317535(CHEMBL1095009 | Gynosaponin S)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of human DNA topoisomerase 2-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317536(20(R)-Ginsenoside Rg3 | CHEMBL1095008)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of human DNA topoisomerase 2-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317537(20(S)-ginsenoside Rg3 | CHEMBL398412)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of human DNA topoisomerase 2-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317538(CHEMBL1095007 | Ginsenoside F2)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of human DNA topoisomerase 2-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317539(CHEMBL473659 | Ginsenoside Rd | ginsenoside-Rd)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of human DNA topoisomerase 2-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317540(CHEMBL507688 | ginsenoside Rb3 | ginsenoside-Rb3)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of human DNA topoisomerase 2-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317541(CHEMBL501515 | Ginsenoside Rb1 | ginsenoside-Rb1)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of human DNA topoisomerase 2-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317542(20(R)-Ginsenoside Rg2 | CHEMBL1095006)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of human DNA topoisomerase 2-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317543(20(S)-Ginsenoside Rg2 | CHEMBL1095005)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of human DNA topoisomerase 2-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317544(CHEMBL1095004 | Ginsenoside F3)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of human DNA topoisomerase 2-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50378778(CHEMBL583152)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of human DNA topoisomerase 2-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50378779(CHEMBL510095)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of human DNA topoisomerase 2-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50377927(Clerodol | Fagarasterol | Farganasterol | LUPEOL |...)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of human DNA topoisomerase 2-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317548(CHEMBL1097034 | lupeol 3-acetate)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of human DNA topoisomerase 2-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317549(2, 3-dihydroxy-12-ursen-28-oic acid | CHEMBL109703...)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of human DNA topoisomerase 2-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50241956((3S,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bR)-4,4,6a...)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of human DNA topoisomerase 2-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317550(3-O-beta-D-glucopyranosyl quinovic acid 28-O-alpha...)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of human DNA topoisomerase 2-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317551(3-O-beta-D-glucopyranosyl-(1-4)-alpha-L-rhamnopyra...)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of human DNA topoisomerase 2-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317552((1S,2R,4aS,6aR,6bR,8aR,10S,12aR,12bR,14bS)-1,2,6b,...)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of human DNA topoisomerase 2-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317553(3-O-alpha-L-rhamnopyranosyl quinovic acid | CHEMBL...)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of human DNA topoisomerase 2-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317554((1S,2R,4aS,6aR,6bR,8aR,10S,12aR,12bR,14bS)-1,2,6b,...)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of human DNA topoisomerase 2-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Stephen F. Austin State University

Curated by ChEMBL
LigandPNGBDBM50317555(3-O-beta-6-deoxy-D-glucopyranosyl cincholic acid28...)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of human DNA topoisomerase 2-mediated relaxation of supercoiled DNA by gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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