Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 50039138
LigandChemical structure of BindingDB Monomer ID 50316640BDBM50316640(5-(4-(aminomethyl)piperidin-1-yl)-1-(2-ethoxyethyl...)
Affinity DataIC50: 0.00700nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316638BDBM50316638(1-(2-ethoxyethyl)-3-ethyl-N7-(4-methylpyridin-2-yl...)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316647BDBM50316647(1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316646BDBM50316646(1-(1-(2-ethoxyethyl)-3-methyl-7-(4-methylpyridin-2...)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316639BDBM50316639(5-(4-(aminomethyl)piperidin-1-yl)-1-(2-ethoxyethyl...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316642BDBM50316642((1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316651BDBM50316651(1-(2-ethoxyethyl)-3-ethyl-N-phenyl-5-(piperazin-1-...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316644BDBM50316644(1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316645BDBM50316645(1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316666BDBM50316666(1-(2-ethoxyethyl)-3-ethyl-N5-methyl-N5-(1-methylpi...)
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316643BDBM50316643(1-(1-(2-ethoxyethyl)-3-methyl-7-(4-methylpyridin-2...)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316663BDBM50316663(1-(2-ethoxyethyl)-3-ethyl-N7-(4-methylpyridin-2-yl...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316670BDBM50316670(1-(2-ethoxyethyl)-3-methyl-N7-(4-methylpyridin-2-y...)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316655BDBM50316655(1-(2-ethoxyethyl)-3-ethyl-N-(4-methylpyridin-2-yl)...)
Affinity DataIC50: 0.380nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316650BDBM50316650(1-(2-ethoxyethyl)-3-ethyl-5-(piperazin-1-yl)-N-(py...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316667BDBM50316667(1-(2-ethoxyethyl)-3-ethyl-N5-methyl-N7-(4-methylpy...)
Affinity DataIC50: 0.420nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316649BDBM50316649(1-(2-ethoxyethyl)-3-methyl-5-(piperazin-1-yl)-N-(p...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316652BDBM50316652(1-(2-ethoxyethyl)-3-methyl-N-(6-methylpyridin-2-yl...)
Affinity DataIC50: 0.650nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316653BDBM50316653(1-(2-ethoxyethyl)-3-ethyl-N-(6-methylpyridin-2-yl)...)
Affinity DataIC50: 0.660nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316664BDBM50316664(1-(2-ethoxyethyl)-3-ethyl-N5-(1-methylpiperidin-4-...)
Affinity DataIC50: 0.720nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316662BDBM50316662(5-(1,4-diazepan-1-yl)-1-(2-ethoxyethyl)-3-ethyl-N-...)
Affinity DataIC50: 0.760nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316669BDBM50316669(5-(4-aminopiperidin-1-yl)-1-(2-ethoxyethyl)-3-ethy...)
Affinity DataIC50: 0.780nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316659BDBM50316659(1-(2-ethoxyethyl)-3-ethyl-5-(4-methylpiperazin-1-y...)
Affinity DataIC50: 0.890nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316661BDBM50316661((S)-1-(2-ethoxyethyl)-3-ethyl-5-(3-methylpiperazin...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316641BDBM50316641(1-(2-ethoxyethyl)-3-methyl-N7-(4-methylpyridin-2-y...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316654BDBM50316654(1-(2-ethoxyethyl)-3-methyl-N-(4-methylpyridin-2-yl...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316665BDBM50316665(1-(2-ethoxyethyl)-3-ethyl-N5-(1-ethylpiperidin-4-y...)
Affinity DataIC50: 2nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316668BDBM50316668(5-(4-aminopiperidin-1-yl)-1-(2-ethoxyethyl)-3-meth...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316648BDBM50316648(1-(2-ethoxyethyl)-3-methyl-N7-(4-methylpyridin-2-y...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316660BDBM50316660((R)-1-(2-ethoxyethyl)-3-ethyl-5-(3-methylpiperazin...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316658BDBM50316658(1-(2-ethoxyethyl)-3-methyl-5-(4-methylpiperazin-1-...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316656BDBM50316656(1-(2-ethoxyethyl)-3-ethyl-N-(5-methylpyridin-2-yl)...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316657BDBM50316657(1-(2-ethoxyethyl)-3-ethyl-N-(3-methylpyridin-2-yl)...)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316647BDBM50316647(1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human ERG by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50316648BDBM50316648(1-(2-ethoxyethyl)-3-methyl-N7-(4-methylpyridin-2-y...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of human ERG by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed