Compile Data Set for Download or QSAR
Report error Found 124 Enz. Inhib. hit(s) with all data for entry = 50032241
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416771(CHEMBL1241641)
Affinity DataKi:  25.1nMAssay Description:Displacement of [3H]-dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412441(SB-744185 | CHEMBL490417)
Affinity DataKi:  63.1nMAssay Description:Displacement of [3H]-dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326140(6-(2-(4-(2-methylquinolin-5-yl)piperazin-1-yl)ethy...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using diethoxyfluorescein/7-benzyloxyquinoline as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416772(CHEMBL1242257)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]-dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326147(N-(cyclopropylmethyl)-6-(2-(4-(2-methylquinolin-5-...)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]-dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416769(CHEMBL1241547)
Affinity DataKi:  398nMAssay Description:Displacement of [3H]-dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416770(CHEMBL1241548)
Affinity DataKi:  398nMAssay Description:Displacement of [3H]-dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326139(6-(2-(4-(2-methylquinolin-5-yl)piperazin-1-yl)ethy...)
Affinity DataKi:  501nMAssay Description:Displacement of [3H]-dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326135(azetidin-1-yl(6-(2-(4-(2-methylquinolin-5-yl)piper...)
Affinity DataKi:  501nMAssay Description:Displacement of [3H]-dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326134(N-cyclobutyl-6-(2-(4-(2-methylquinolin-5-yl)pipera...)
Affinity DataKi:  501nMAssay Description:Displacement of [3H]-dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326146(N-cyclopropyl-6-(2-(4-(2-methylquinolin-5-yl)piper...)
Affinity DataKi:  631nMAssay Description:Displacement of [3H]-dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413077(CHEMBL522257)
Affinity DataKi:  794nMAssay Description:Displacement of [3H]-dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326140(6-(2-(4-(2-methylquinolin-5-yl)piperazin-1-yl)ethy...)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]-dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326137(6-(2-(4-(2-methylquinolin-5-yl)piperazin-1-yl)ethy...)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]-dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326150((6-(2-(4-(2-methylquinolin-5-yl)piperazin-1-yl)eth...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human ERG tail current by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326139(6-(2-(4-(2-methylquinolin-5-yl)piperazin-1-yl)ethy...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant CYP1A2 preincubated for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326149((6-(2-(4-(2-methylquinolin-5-yl)piperazin-1-yl)eth...)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]-dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326148((6-(2-(4-(2-methylquinolin-5-yl)piperazin-1-yl)eth...)
Affinity DataKi:  1.26E+3nMAssay Description:Displacement of [3H]-dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326133(6-(2-(4-(2-methylquinolin-5-yl)piperazin-1-yl)ethy...)
Affinity DataKi:  1.58E+3nMAssay Description:Displacement of [3H]-dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326132(N-methyl-6-(2-(4-(2-methylquinolin-5-yl)piperazin-...)
Affinity DataIC50: 1.58E+3nMAssay Description:Inhibition of human ERG tail current by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326137(6-(2-(4-(2-methylquinolin-5-yl)piperazin-1-yl)ethy...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human recombinant CYP2C9 preincubated for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326145(N-isopropyl-6-(2-(4-(2-methylquinolin-5-yl)piperaz...)
Affinity DataKi:  2.51E+3nMAssay Description:Displacement of [3H]-dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326142(3-methyl-6-(2-(4-(2-methylquinolin-5-yl)piperazin-...)
Affinity DataKi:  2.51E+3nMAssay Description:Displacement of [3H]-dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326136(1-(6-(2-(4-(2-methylquinolin-5-yl)piperazin-1-yl)e...)
Affinity DataKi:  2.51E+3nMAssay Description:Displacement of [3H]-dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413549(CHEMBL513715)
Affinity DataKi:  2.51E+3nMAssay Description:Displacement of [3H]-dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326134(N-cyclobutyl-6-(2-(4-(2-methylquinolin-5-yl)pipera...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human recombinant CYP2C19 preincubated for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326132(N-methyl-6-(2-(4-(2-methylquinolin-5-yl)piperazin-...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes measured after incubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326144(N,N-dimethyl-6-(2-(4-(2-methylquinolin-5-yl)pipera...)
Affinity DataKi:  3.98E+3nMAssay Description:Displacement of [3H]-dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413550(CHEMBL469345)
Affinity DataKi:  3.98E+3nMAssay Description:Displacement of [3H]-dofetilide from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326133(6-(2-(4-(2-methylquinolin-5-yl)piperazin-1-yl)ethy...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human recombinant CYP2C9 preincubated for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326137(6-(2-(4-(2-methylquinolin-5-yl)piperazin-1-yl)ethy...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using diethoxyfluorescein/7-benzyloxyquinoline as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326136(1-(6-(2-(4-(2-methylquinolin-5-yl)piperazin-1-yl)e...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human recombinant CYP2C9 preincubated for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326138(ethyl 6-(2-(4-(2-methylquinolin-5-yl)piperazin-1-y...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human recombinant CYP2C9 preincubated for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326135(azetidin-1-yl(6-(2-(4-(2-methylquinolin-5-yl)piper...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human recombinant CYP2C19 preincubated for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326136(1-(6-(2-(4-(2-methylquinolin-5-yl)piperazin-1-yl)e...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human recombinant CYP1A2 preincubated for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326133(6-(2-(4-(2-methylquinolin-5-yl)piperazin-1-yl)ethy...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human recombinant CYP2C19 preincubated for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326132(N-methyl-6-(2-(4-(2-methylquinolin-5-yl)piperazin-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes measured after incubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326142(3-methyl-6-(2-(4-(2-methylquinolin-5-yl)piperazin-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant CYP2C9 preincubated for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326142(3-methyl-6-(2-(4-(2-methylquinolin-5-yl)piperazin-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant CYP2C19 preincubated for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326143(1-(6-(2-(4-(2-methylquinolin-5-yl)piperazin-1-yl)e...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant CYP2C9 preincubated for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326143(1-(6-(2-(4-(2-methylquinolin-5-yl)piperazin-1-yl)e...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant CYP2C19 preincubated for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326143(1-(6-(2-(4-(2-methylquinolin-5-yl)piperazin-1-yl)e...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using diethoxyfluorescein as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326143(1-(6-(2-(4-(2-methylquinolin-5-yl)piperazin-1-yl)e...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant CYP1A2 preincubated for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326142(3-methyl-6-(2-(4-(2-methylquinolin-5-yl)piperazin-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using diethoxyfluorescein as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326142(3-methyl-6-(2-(4-(2-methylquinolin-5-yl)piperazin-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant CYP1A2 preincubated for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326142(3-methyl-6-(2-(4-(2-methylquinolin-5-yl)piperazin-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant CYPD6 preincubated for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326142(3-methyl-6-(2-(4-(2-methylquinolin-5-yl)piperazin-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using diethoxyfluorescein/7-benzyloxyquinoline as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326132(N-methyl-6-(2-(4-(2-methylquinolin-5-yl)piperazin-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes measured after incubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326143(1-(6-(2-(4-(2-methylquinolin-5-yl)piperazin-1-yl)e...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant CYPD6 preincubated for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50326143(1-(6-(2-(4-(2-methylquinolin-5-yl)piperazin-1-yl)e...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using diethoxyfluorescein/7-benzyloxyquinoline as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
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