Compile Data Set for Download or QSAR
Report error Found 92 Enz. Inhib. hit(s) with all data for entry = 50039260
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324117BDBM50324117(Methyl 2-((1H-Imidazol-1-yl)methyl)-4-(2-chloro-4-...)
Affinity DataIC50: 9nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324157BDBM50324157(Methyl 4-(2-Chloro-4-fluorophenyl)-5-cyano-1,4-dih...)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324116BDBM50324116((R)-Methyl 2-((1H-Tetrazol-1-yl)methyl)-4-(2-chlor...)
Affinity DataIC50: 52nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324158BDBM50324158(Methyl 4-(2-Chloro-4-fluorophenyl)-5-cyano-6-methy...)
Affinity DataIC50: 52nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324118BDBM50324118(Methyl 2-((1H-Pyrazol-1-yl)methyl)-4-(2-chloro-4-f...)
Affinity DataIC50: 54nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324151BDBM50324151(Methyl 2-Butyl-4-(2-chlorophenyl)-5-cyano-1,4-dihy...)
Affinity DataIC50: 58nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50318295BDBM50318295(tert-Butyl (4R)-4-(2-Chloro-4-fluorophenyl)-5-cyan...)
Affinity DataIC50: 59nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324115BDBM50324115(Methyl 2-((1H-Tetrazol-1-yl)methyl)-4-(2-chloro-4-...)
Affinity DataIC50: 64nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324149BDBM50324149(Methyl 4-(2-Chlorophenyl)-5-cyano-1,4-dihydro-6-me...)
Affinity DataIC50: 64nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324139BDBM50324139(3-tert-butyl 5-methyl 4-(2-chloro-4-fluorophenyl)-...)
Affinity DataIC50: 78nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324146BDBM50324146(Methyl 4-(2-Chloro-4-fluorophenyl)-5-cyano-1,4-dih...)
Affinity DataIC50: 92nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324157BDBM50324157(Methyl 4-(2-Chloro-4-fluorophenyl)-5-cyano-1,4-dih...)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at androgen receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324119BDBM50324119(Methyl 2-((1H-1,2,4-Triazol-1-yl)methyl)-4-(2-chlo...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50318300BDBM50318300(CHEMBL1095097 | SC-66110 | EPLERENONE)
Affinity DataIC50: 122nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324119BDBM50324119(Methyl 2-((1H-1,2,4-Triazol-1-yl)methyl)-4-(2-chlo...)
Affinity DataIC50: 123nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50318298BDBM50318298((+)-(R)-3-tert-butyl 5-methyl 2,6-dimethyl-4-(3-ni...)
Affinity DataIC50: 126nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324117BDBM50324117(Methyl 2-((1H-Imidazol-1-yl)methyl)-4-(2-chloro-4-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324149BDBM50324149(Methyl 4-(2-Chlorophenyl)-5-cyano-1,4-dihydro-6-me...)
Affinity DataIC50: 200nMAssay Description:Antagonist activity at progesterone receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324143BDBM50324143(tert-Butyl 5-Cyano-4-(2,4-difluorophenyl)-2,6-dime...)
Affinity DataIC50: 201nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324150BDBM50324150(Methyl 4-(2-Chlorophenyl)-5-cyano-1,4-dihydro-2-is...)
Affinity DataIC50: 208nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324124BDBM50324124(3-tert-butyl 5-methyl 2,6-dimethyl-4-o-tolyl-1,4-d...)
Affinity DataIC50: 208nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324123BDBM50324123(3-tert-butyl 5-methyl 2,6-dimethyl-4-(2-(trifluoro...)
Affinity DataIC50: 224nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324148BDBM50324148(Methyl 4-(2-Chlorophenyl)-5-cyano-2-ethyl-1,4-dihy...)
Affinity DataIC50: 232nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324159BDBM50324159(Methyl 4-(2-Chloro-4-fluorophenyl)-5-cyano-1,6-dim...)
Affinity DataIC50: 275nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324135BDBM50324135(3-tert-butyl 5-methyl 4-(4-fluorophenyl)-2,6-dimet...)
Affinity DataIC50: 288nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324146BDBM50324146(Methyl 4-(2-Chloro-4-fluorophenyl)-5-cyano-1,4-dih...)
Affinity DataIC50: 300nMAssay Description:Antagonist activity at androgen receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324149BDBM50324149(Methyl 4-(2-Chlorophenyl)-5-cyano-1,4-dihydro-6-me...)
Affinity DataIC50: 300nMAssay Description:Antagonist activity at androgen receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324151BDBM50324151(Methyl 2-Butyl-4-(2-chlorophenyl)-5-cyano-1,4-dihy...)
Affinity DataIC50: 300nMAssay Description:Antagonist activity at progesterone receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324116BDBM50324116((R)-Methyl 2-((1H-Tetrazol-1-yl)methyl)-4-(2-chlor...)
Affinity DataIC50: 300nMAssay Description:Antagonist activity at androgen receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324133BDBM50324133(3-tert-butyl 5-methyl 2,6-dimethyl-4-(4-(trifluoro...)
Affinity DataIC50: 309nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324138BDBM50324138(3-tert-butyl 5-methyl 4-(4-chlorophenyl)-2,6-dimet...)
Affinity DataIC50: 319nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324141BDBM50324141(tert-Butyl 5-Cyano-4-(4-fluorophenyl)-2,6-dimethyl...)
Affinity DataIC50: 329nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324129BDBM50324129(3-tert-butyl 5-methyl 4-(3-chlorophenyl)-2,6-dimet...)
Affinity DataIC50: 518nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324125BDBM50324125(3-tert-butyl 5-methyl 4-(2-methoxyphenyl)-2,6-dime...)
Affinity DataIC50: 553nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324140BDBM50324140(3-tert-butyl 5-methyl 4-(4-chloro-3-fluorophenyl)-...)
Affinity DataIC50: 574nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324147BDBM50324147(Methyl 4-(2-Chlorophenyl)-5-cyano-1,4-dihydro-2,6-...)
Affinity DataIC50: 594nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324118BDBM50324118(Methyl 2-((1H-Pyrazol-1-yl)methyl)-4-(2-chloro-4-f...)
Affinity DataIC50: 600nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324121BDBM50324121(3-tert-butyl 5-methyl 4-(2-chlorophenyl)-2,6-dimet...)
Affinity DataIC50: 621nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324152BDBM50324152(Methyl 4-(2-Chlorophenyl)-5-cyano-1,4-dihydro-2-(2...)
Affinity DataIC50: 655nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324142BDBM50324142(tert-butyl 5-cyano-4-(4-fluorophenyl)-2,6-dimethyl...)
Affinity DataIC50: 661nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324157BDBM50324157(Methyl 4-(2-Chloro-4-fluorophenyl)-5-cyano-1,4-dih...)
Affinity DataIC50: 700nMAssay Description:Antagonist activity at glucocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324130BDBM50324130(3-tert-butyl 5-methyl 2,6-dimethyl-4-(3-(trifluoro...)
Affinity DataIC50: 702nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324119BDBM50324119(Methyl 2-((1H-1,2,4-Triazol-1-yl)methyl)-4-(2-chlo...)
Affinity DataIC50: 800nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324158BDBM50324158(Methyl 4-(2-Chloro-4-fluorophenyl)-5-cyano-6-methy...)
Affinity DataIC50: 800nMAssay Description:Antagonist activity at androgen receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324118BDBM50324118(Methyl 2-((1H-Pyrazol-1-yl)methyl)-4-(2-chloro-4-f...)
Affinity DataIC50: 800nMAssay Description:Antagonist activity at androgen receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324155BDBM50324155(Methyl 2-Benzyl-4-(2-chlorophenyl)-5-cyano-1,4-dih...)
Affinity DataIC50: 852nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324128BDBM50324128(3-tert-butyl 5-methyl 4-(3-methoxyphenyl)-2,6-dime...)
Affinity DataIC50: 888nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324151BDBM50324151(Methyl 2-Butyl-4-(2-chlorophenyl)-5-cyano-1,4-dihy...)
Affinity DataIC50: 900nMAssay Description:Antagonist activity at androgen receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324146BDBM50324146(Methyl 4-(2-Chloro-4-fluorophenyl)-5-cyano-1,4-dih...)
Affinity DataIC50: 900nMAssay Description:Antagonist activity at progesterone receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324153BDBM50324153(Ethyl 4-(2-Chlorophenyl)-5-cyano-2-methyl-6-phenyl...)
Affinity DataIC50: 923nMAssay Description:Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
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