Compile Data Set for Download or QSAR
Report error Found 31 Enz. Inhib. hit(s) with all data for entry = 50032192
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325767BDBM50325767(3-(2'-chlorobiphenyl-3-yl)-1H-pyrazole-1-carboxami...)
Affinity DataKi:  0.0180nMAssay Description:Inhibition of human Nav 1.7 channel by electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325766BDBM50325766(3-(2'-chlorobiphenyl-4-yl)-1H-pyrazole-1-carboxami...)
Affinity DataKi:  0.111nMAssay Description:Inhibition of human Nav 1.7 channel by electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325765BDBM50325765(3-(4-(4-chloro-2-fluorophenoxy)phenyl)-1H-pyrazole...)
Affinity DataKi:  13nMAssay Description:Inhibition of human Nav 1.7 channel by electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325764BDBM50325764(4-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazole-2-c...)
Affinity DataKi:  15nMAssay Description:Inhibition of human Nav 1.7 channel by electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325779BDBM50325779(1-(2',6'-bis(trifluoromethyl)biphenyl-3-yl)-5-meth...)
Affinity DataIC50: 41nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325769BDBM50325769(1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H-pyrazole...)
Affinity DataIC50: 65nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325778BDBM50325778(1-(2'-fluoro-6'-(trifluoromethyl)biphenyl-3-yl)-5-...)
Affinity DataIC50: 71nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325770BDBM50325770(5-amino-1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H-...)
Affinity DataIC50: 111nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325781BDBM50325781(5-methyl-1-(2'-(2,2,3,3,3-pentafluoropropoxy)biphe...)
Affinity DataIC50: 128nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325782BDBM50325782(1-(6-fluoro-2'-(trifluoromethoxy)biphenyl-3-yl)-5-...)
Affinity DataIC50: 162nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325774BDBM50325774(5-methyl-1-(2'-(trifluoromethyl)biphenyl-3-yl)-1H-...)
Affinity DataIC50: 163nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325780BDBM50325780(5-methyl-1-(2'-(2,2,2-trifluoroethoxy)biphenyl-3-y...)
Affinity DataIC50: 187nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325783BDBM50325783(1-(4-fluoro-2'-(trifluoromethoxy)biphenyl-3-yl)-5-...)
Affinity DataIC50: 222nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325771BDBM50325771(5-methyl-1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H...)
Affinity DataIC50: 224nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325776BDBM50325776(1-(4'-chloro-2'-(trifluoromethyl)biphenyl-3-yl)-5-...)
Affinity DataIC50: 243nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325763BDBM50325763(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-5-meth...)
Affinity DataIC50: 272nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325784BDBM50325784(1-(2',6-bis(trifluoromethoxy)biphenyl-3-yl)-5-meth...)
Affinity DataIC50: 373nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325777BDBM50325777(1-(5'-fluoro-2'-(trifluoromethyl)biphenyl-3-yl)-5-...)
Affinity DataIC50: 412nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325762BDBM50325762(1-(2',4'-bis(trifluoromethyl)biphenyl-3-yl)-5-meth...)
Affinity DataIC50: 426nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325768BDBM50325768(3-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H-pyrazole...)
Affinity DataIC50: 508nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325773BDBM50325773(1-(2'-chlorobiphenyl-3-yl)-5-methyl-1H-pyrazole-3-...)
Affinity DataIC50: 738nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325775BDBM50325775(1-(3'-fluoro-2'-(trifluoromethyl)biphenyl-3-yl)-5-...)
Affinity DataIC50: 781nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325785BDBM50325785(5-methyl-1-(2'-phenoxybiphenyl-3-yl)-1H-pyrazole-3...)
Affinity DataIC50: 875nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325772BDBM50325772(5-tert-butyl-1-(2'-(trifluoromethoxy)biphenyl-3-yl...)
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325763BDBM50325763(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-5-meth...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325762BDBM50325762(1-(2',4'-bis(trifluoromethyl)biphenyl-3-yl)-5-meth...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325762BDBM50325762(1-(2',4'-bis(trifluoromethyl)biphenyl-3-yl)-5-meth...)
Affinity DataIC50: 2.50E+4nMAssay Description:Induction of human PXR by induction assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325763BDBM50325763(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-5-meth...)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325763BDBM50325763(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-5-meth...)
Affinity DataIC50: 5.10E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325762BDBM50325762(1-(2',4'-bis(trifluoromethyl)biphenyl-3-yl)-5-meth...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325762BDBM50325762(1-(2',4'-bis(trifluoromethyl)biphenyl-3-yl)-5-meth...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed