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Found 9 Enz. Inhib. hit(s) with all data for entry = 50032924
TargetNeutrophil elastase(Homo sapiens (Human))
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50326056((1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazin...)
Affinity DataIC50:  680nMAssay Description:Inhibition of human leukocyte elastase after 60 mins fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50326056((1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazin...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of human CatB after 60 mins fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 2(Rattus norvegicus)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50336545((1R,2S)-1-((2S,4R)-4-(8-bromo-2-(2-isobutyramidoth...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of rat hapatic, acyl coA cholesterol acetyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM12311((1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxop...)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of human CatB after 60 mins fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase 2B catalytic subunit beta isoform(Homo sapiens (Human))
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50336545((1R,2S)-1-((2S,4R)-4-(8-bromo-2-(2-isobutyramidoth...)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of human PP2BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM12311((1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxop...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of human leukocyte elastase after 60 mins fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50336545((1R,2S)-1-((2S,4R)-4-(8-bromo-2-(2-isobutyramidoth...)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of human CatB after 60 mins fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50336545((1R,2S)-1-((2S,4R)-4-(8-bromo-2-(2-isobutyramidoth...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human leukocyte elastase after 60 mins fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Mus musculus)
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50336545((1R,2S)-1-((2S,4R)-4-(8-bromo-2-(2-isobutyramidoth...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of mouse recombinant cathepsin E by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed