Compile Data Set for Download or QSAR
maximum 50k data
Found 40 Enz. Inhib. hit(s) with all data for entry = 50032412
TargetCytochrome P450 3A4(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328778(CHEMBL1270362 | N-((2S,3R)-4-(1-(3-(1,1-difluoro-2...)
Affinity DataIC50:  4nMAssay Description:Inhibition of CYP3A4 in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302838(CHEMBL572081 | N-((2S,3R)-4-(1-(3-(1H-pyrazol-1-yl...)
Affinity DataIC50:  22nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302841(CHEMBL571860 | N-((2S,3R)-4-(1-(3-tert-butylphenyl...)
Affinity DataIC50:  25nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328778(CHEMBL1270362 | N-((2S,3R)-4-(1-(3-(1,1-difluoro-2...)
Affinity DataIC50:  46nMAssay Description:Inhibition of CYP3A4 in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302841(CHEMBL571860 | N-((2S,3R)-4-(1-(3-tert-butylphenyl...)
Affinity DataIC50:  47nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302838(CHEMBL572081 | N-((2S,3R)-4-(1-(3-(1H-pyrazol-1-yl...)
Affinity DataIC50:  59nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302839(CHEMBL570556 | N-((2S,3R)-4-(4-(3-tert-butylphenyl...)
Affinity DataIC50:  61nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323493(CHEMBL1209106 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  88nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328778(CHEMBL1270362 | N-((2S,3R)-4-(1-(3-(1,1-difluoro-2...)
Affinity DataIC50:  110nMAssay Description:Inhibition of CYP3A4 by competitive inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328786(CHEMBL1269840 | N-((2S,3R)-4-(4-(3-(1H-pyrazol-1-y...)
Affinity DataIC50:  110nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328050(CHEMBL1257303 | N-((2S,3R)-4-(1-(3-tert-butylpheny...)
Affinity DataIC50:  140nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50323493(CHEMBL1209106 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  140nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328785(CHEMBL1269841 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  150nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328786(CHEMBL1269840 | N-((2S,3R)-4-(4-(3-(1H-pyrazol-1-y...)
Affinity DataIC50:  160nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328783(CHEMBL1269949 | N-((2S,3R)-4-(2-(3-tert-butylpheny...)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328050(CHEMBL1257303 | N-((2S,3R)-4-(1-(3-tert-butylpheny...)
Affinity DataIC50:  220nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50302839(CHEMBL570556 | N-((2S,3R)-4-(4-(3-tert-butylphenyl...)
Affinity DataIC50:  230nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328778(CHEMBL1270362 | N-((2S,3R)-4-(1-(3-(1,1-difluoro-2...)
Affinity DataIC50:  230nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328049(CHEMBL1257302 | N-((2S,3R)-4-(1-(6-tert-butylpyrim...)
Affinity DataIC50:  250nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328785(CHEMBL1269841 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  290nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328779(CHEMBL1270263 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  290nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328061(CHEMBL1258002 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  350nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328776(CHEMBL1270458 | N-((2S,3R)-4-(1-(3-tert-butylpheny...)
Affinity DataIC50:  380nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328777(CHEMBL1270363 | N-((2S,3R)-4-(1-(3-(1,3-difluoro-2...)
Affinity DataIC50:  390nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328779(CHEMBL1270263 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  480nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328781(CHEMBL1270164 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  480nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328778(CHEMBL1270362 | N-((2S,3R)-4-(1-(3-(1,1-difluoro-2...)
Affinity DataIC50:  490nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328777(CHEMBL1270363 | N-((2S,3R)-4-(1-(3-(1,3-difluoro-2...)
Affinity DataIC50:  500nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328776(CHEMBL1270458 | N-((2S,3R)-4-(1-(3-tert-butylpheny...)
Affinity DataIC50:  610nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328783(CHEMBL1269949 | N-((2S,3R)-4-(2-(3-tert-butylpheny...)
Affinity DataIC50:  610nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328061(CHEMBL1258002 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  720nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328782(CHEMBL1270163 | N-((2S,3R)-4-(1-(3-(1H-pyrazol-1-y...)
Affinity DataIC50:  750nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328781(CHEMBL1270164 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  760nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328782(CHEMBL1270163 | N-((2S,3R)-4-(1-(3-(1H-pyrazol-1-y...)
Affinity DataIC50:  980nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328780(CHEMBL1270262 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328784(CHEMBL1269948 | N-((2S,3R)-4-(3-tert-butylbenzylam...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328780(CHEMBL1270262 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328775(CHEMBL1270459 | N-((2S,3R)-4-((1R,2R)-1-(3-(1,1-di...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328049(CHEMBL1257302 | N-((2S,3R)-4-(1-(6-tert-butylpyrim...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of recombinant BACE1 purified from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328784(CHEMBL1269948 | N-((2S,3R)-4-(3-tert-butylbenzylam...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of cathepsin-DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed