Compile Data Set for Download or QSAR
Report error Found 28 Enz. Inhib. hit(s) with all data for entry = 50032414
TargetHistamine H3 receptor(Mouse)
Athersys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22541BDBM22541(VUF 9153 | N''-[(4-chlorophenyl)methyl]{[3-(1H-imi...)
Affinity DataIC50: 1nMAssay Description:Antagonist activity against mouse histamine H3 receptor expressed in human HT1080 cells assessed as inhibition of (R)-alpha-methylhistamine-induced i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Athersys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22541BDBM22541(VUF 9153 | N''-[(4-chlorophenyl)methyl]{[3-(1H-imi...)
Affinity DataIC50: 1nMAssay Description:Antagonist activity against human histamine H3 receptor expressed in human HT1080 cells assessed as inhibition of (R)-alpha-methylhistamine-induced i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Athersys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50328807BDBM50328807((2R,4S,5S)-1,2,5-trimethyl-4-(2-(naphthalen-1-yl)e...)
Affinity DataIC50: 2nMAssay Description:Antagonist activity against human histamine H3 receptor expressed in human HT1080 cells assessed as inhibition of (R)-alpha-methylhistamine-induced i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Athersys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50328809BDBM50328809(rac-1,2,5-trimethyl-4-(2-(naphthalen-2-yl)ethyl)pi...)
Affinity DataIC50: 2nMAssay Description:Antagonist activity against human histamine H3 receptor expressed in human HT1080 cells assessed as inhibition of (R)-alpha-methylhistamine-induced i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Athersys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50328810BDBM50328810(rac-6-methyl-7-(naphthalen-1-ylethynyl)octahydroin...)
Affinity DataIC50: 5nMAssay Description:Antagonist activity against human histamine H3 receptor expressed in human HT1080 cells assessed as inhibition of (R)-alpha-methylhistamine-induced i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Athersys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50328802BDBM50328802((2R,4S,5S)-1,2,5-trimethyl-4-(naphthalen-1-ylethyn...)
Affinity DataIC50: 9nMAssay Description:Antagonist activity against human histamine H3 receptor expressed in human HT1080 cells assessed as inhibition of (R)-alpha-methylhistamine-induced i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Athersys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50328801BDBM50328801(1,2,5-trimethyl-4-(naphthalen-1-ylethynyl)piperidi...)
Affinity DataIC50: 11nMAssay Description:Antagonist activity against human histamine H3 receptor expressed in human HT1080 cells assessed as inhibition of (R)-alpha-methylhistamine-induced i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Athersys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50328812BDBM50328812(rac-1,2,5-trimethyl-4-(quinolin-5-ylethynyl)piperi...)
Affinity DataIC50: 12nMAssay Description:Antagonist activity against human histamine H3 receptor expressed in human HT1080 cells assessed as inhibition of (R)-alpha-methylhistamine-induced i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Athersys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50328811BDBM50328811(rac-6-methyl-7-(2-(naphthalen-1-yl)ethyl)octahydro...)
Affinity DataIC50: 14nMAssay Description:Antagonist activity against human histamine H3 receptor expressed in human HT1080 cells assessed as inhibition of (R)-alpha-methylhistamine-induced i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Athersys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50328806BDBM50328806(rac-1,2,5-trimethyl-4-(2-(naphthalen-1-yl)ethyl)pi...)
Affinity DataIC50: 17nMAssay Description:Antagonist activity against human histamine H3 receptor expressed in human HT1080 cells assessed as inhibition of (R)-alpha-methylhistamine-induced i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Athersys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50328805BDBM50328805(rac-1,2,5-trimethyl-4-(2-(naphthalen-1-yl)vinyl)pi...)
Affinity DataIC50: 20nMAssay Description:Antagonist activity against human histamine H3 receptor expressed in human HT1080 cells assessed as inhibition of (R)-alpha-methylhistamine-induced i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Athersys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50328803BDBM50328803((2S,4R,5R)-1,2,5-trimethyl-4-(naphthalen-1-ylethyn...)
Affinity DataIC50: 41nMAssay Description:Antagonist activity against human histamine H3 receptor expressed in human HT1080 cells assessed as inhibition of (R)-alpha-methylhistamine-induced i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Athersys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50328808BDBM50328808(rac-1,2,5-trimethyl-4-(naphthalen-2-ylethynyl)pipe...)
Affinity DataIC50: 84nMAssay Description:Antagonist activity against human histamine H3 receptor expressed in human HT1080 cells assessed as inhibition of (R)-alpha-methylhistamine-induced i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Mouse)
Athersys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50328807BDBM50328807((2R,4S,5S)-1,2,5-trimethyl-4-(2-(naphthalen-1-yl)e...)
Affinity DataIC50: 85nMAssay Description:Antagonist activity against mouse histamine H3 receptor expressed in human HT1080 cells assessed as inhibition of (R)-alpha-methylhistamine-induced i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Mouse)
Athersys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50328802BDBM50328802((2R,4S,5S)-1,2,5-trimethyl-4-(naphthalen-1-ylethyn...)
Affinity DataIC50: 119nMAssay Description:Antagonist activity against mouse histamine H3 receptor expressed in human HT1080 cells assessed as inhibition of (R)-alpha-methylhistamine-induced i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Mouse)
Athersys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50328809BDBM50328809(rac-1,2,5-trimethyl-4-(2-(naphthalen-2-yl)ethyl)pi...)
Affinity DataIC50: 122nMAssay Description:Antagonist activity against mouse histamine H3 receptor expressed in human HT1080 cells assessed as inhibition of (R)-alpha-methylhistamine-induced i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Mouse)
Athersys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50328801BDBM50328801(1,2,5-trimethyl-4-(naphthalen-1-ylethynyl)piperidi...)
Affinity DataIC50: 280nMAssay Description:Antagonist activity against mouse histamine H3 receptor expressed in human HT1080 cells assessed as inhibition of (R)-alpha-methylhistamine-induced i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Mouse)
Athersys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50328810BDBM50328810(rac-6-methyl-7-(naphthalen-1-ylethynyl)octahydroin...)
Affinity DataIC50: 280nMAssay Description:Antagonist activity against mouse histamine H3 receptor expressed in human HT1080 cells assessed as inhibition of (R)-alpha-methylhistamine-induced i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Mouse)
Athersys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50328811BDBM50328811(rac-6-methyl-7-(2-(naphthalen-1-yl)ethyl)octahydro...)
Affinity DataIC50: 345nMAssay Description:Antagonist activity against mouse histamine H3 receptor expressed in human HT1080 cells assessed as inhibition of (R)-alpha-methylhistamine-induced i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Mouse)
Athersys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50328806BDBM50328806(rac-1,2,5-trimethyl-4-(2-(naphthalen-1-yl)ethyl)pi...)
Affinity DataIC50: 480nMAssay Description:Antagonist activity against mouse histamine H3 receptor expressed in human HT1080 cells assessed as inhibition of (R)-alpha-methylhistamine-induced i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Mouse)
Athersys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50328805BDBM50328805(rac-1,2,5-trimethyl-4-(2-(naphthalen-1-yl)vinyl)pi...)
Affinity DataIC50: 570nMAssay Description:Antagonist activity against mouse histamine H3 receptor expressed in human HT1080 cells assessed as inhibition of (R)-alpha-methylhistamine-induced i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Mouse)
Athersys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50328812BDBM50328812(rac-1,2,5-trimethyl-4-(quinolin-5-ylethynyl)piperi...)
Affinity DataIC50: 690nMAssay Description:Antagonist activity against mouse histamine H3 receptor expressed in human HT1080 cells assessed as inhibition of (R)-alpha-methylhistamine-induced i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Athersys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50328813BDBM50328813(rac-1,2,5-trimethyl-4-(quinolin-8-ylethynyl)piperi...)
Affinity DataIC50: 709nMAssay Description:Antagonist activity against human histamine H3 receptor expressed in human HT1080 cells assessed as inhibition of (R)-alpha-methylhistamine-induced i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Mouse)
Athersys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50328808BDBM50328808(rac-1,2,5-trimethyl-4-(naphthalen-2-ylethynyl)pipe...)
Affinity DataIC50: 810nMAssay Description:Antagonist activity against mouse histamine H3 receptor expressed in human HT1080 cells assessed as inhibition of (R)-alpha-methylhistamine-induced i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Mouse)
Athersys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50328803BDBM50328803((2S,4R,5R)-1,2,5-trimethyl-4-(naphthalen-1-ylethyn...)
Affinity DataIC50: 1.32E+3nMAssay Description:Antagonist activity against mouse histamine H3 receptor expressed in human HT1080 cells assessed as inhibition of (R)-alpha-methylhistamine-induced i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Athersys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50328804BDBM50328804(rac-1,2,5-trimethyl-4-(naphthalen-1-ylethynyl)pipe...)
Affinity DataIC50: 5.51E+3nMAssay Description:Antagonist activity against human histamine H3 receptor expressed in human HT1080 cells assessed as inhibition of (R)-alpha-methylhistamine-induced i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Mouse)
Athersys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50328813BDBM50328813(rac-1,2,5-trimethyl-4-(quinolin-8-ylethynyl)piperi...)
Affinity DataIC50: 9.73E+3nMAssay Description:Antagonist activity against mouse histamine H3 receptor expressed in human HT1080 cells assessed as inhibition of (R)-alpha-methylhistamine-induced i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Mouse)
Athersys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50328804BDBM50328804(rac-1,2,5-trimethyl-4-(naphthalen-1-ylethynyl)pipe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity against mouse histamine H3 receptor expressed in human HT1080 cells assessed as inhibition of (R)-alpha-methylhistamine-induced i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed