Compile Data Set for Download or QSAR
Report error Found 200 Enz. Inhib. hit(s) with all data for entry = 50032455
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329554BDBM50329554((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(4-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329517BDBM50329517((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(2-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329553BDBM50329553((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(4-...)
Affinity DataEC50:  10nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells assessed as reduction in amyloid beta level by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50303727BDBM50303727((4R)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)p...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329546BDBM50329546((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(3-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329565BDBM50329565((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(3,...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329556BDBM50329556((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(6-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329552BDBM50329552((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(3-...)
Affinity DataEC50:  10nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells assessed as reduction in amyloid beta level by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329558BDBM50329558((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(4-flu...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329547BDBM50329547((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(4-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329571BDBM50329571((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(4-flu...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329568BDBM50329568((R)-2-amino-4-(4-(difluoromethoxy)-3-methylphenyl)...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329576BDBM50329576((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(4-flu...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329573BDBM50329573((S)-2-amino-4-(3-(cyclopropylethynyl)phenyl)-4-(4-...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329569BDBM50329569((R)-2-amino-4-(3-(cyclopropylethynyl)-4-fluorophen...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329549BDBM50329549((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329537BDBM50329537((R,E)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329574BDBM50329574((R)-2-amino-4-(4-(difluoromethoxy)-3-methylphenyl)...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329555BDBM50329555((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-((R...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329554BDBM50329554((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(4-...)
Affinity DataEC50:  20nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells assessed as reduction in amyloid beta level by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329561BDBM50329561((R)-2-amino-4-(3-(cyclopropylmethoxy)phenyl)-4-(4-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329552BDBM50329552((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(3-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50303731BDBM50303731((5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329535BDBM50329535((R,E)-2-amino-4-(3-(2-cyclopropyl-1-fluorovinyl)ph...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50303727BDBM50303727((4R)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)p...)
Affinity DataEC50:  20nMAssay Description:Inhibition of BACE1 by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329553BDBM50329553((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(4-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50303731BDBM50303731((5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3...)
Affinity DataEC50:  20nMAssay Description:Inhibition of BACE1 by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329538BDBM50329538((R,E)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329556BDBM50329556((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(6-...)
Affinity DataEC50:  20nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells assessed as reduction in amyloid beta level by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329550BDBM50329550((R)-2-amino-4-(3-(cyclopropylethynyl)phenyl)-4-(4-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329570BDBM50329570((R)-2-amino-4-(3-(cyclopropylethynyl)-4-fluorophen...)
Affinity DataIC50: 21nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329543BDBM50329543((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl...)
Affinity DataIC50: 22nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329517BDBM50329517((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(2-...)
Affinity DataEC50:  27nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells assessed as reduction in amyloid beta level by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329575BDBM50329575((R)-2-amino-4-(4-(difluoromethoxy)-3-methylphenyl)...)
Affinity DataIC50: 28nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329533BDBM50329533((R,E)-2-amino-4-(3-(4,4-difluorobut-1-enyl)phenyl)...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329567BDBM50329567((R)-2-amino-4-(3-(4,4-difluorobut-3-enyloxy)phenyl...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329520BDBM50329520((R)-2-amino-4-(4-(2-fluoroethoxy)phenyl)-4-(3-(2-f...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329525BDBM50329525((R)-2-amino-4-(3-butylphenyl)-4-(4-(difluoromethox...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329572BDBM50329572((R)-2-amino-4-(3-(2,2-difluoroethoxy)-4-fluorophen...)
Affinity DataEC50:  30nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells assessed as reduction in amyloid beta level by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329545BDBM50329545((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329571BDBM50329571((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(4-flu...)
Affinity DataEC50:  30nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells assessed as reduction in amyloid beta level by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329563BDBM50329563((R)-2-amino-4-(3-(2,2-difluoroethoxy)phenyl)-4-(4-...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329566BDBM50329566((R)-2-amino-4-(3-(4,4-difluorobut-3-enyloxy)-4-flu...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329519BDBM50329519((R)-2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-4-(...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329568BDBM50329568((R)-2-amino-4-(4-(difluoromethoxy)-3-methylphenyl)...)
Affinity DataEC50:  30nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells assessed as reduction in amyloid beta level by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329558BDBM50329558((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(4-flu...)
Affinity DataEC50:  40nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells assessed as reduction in amyloid beta level by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329532BDBM50329532((R,E)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329537BDBM50329537((R,E)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(...)
Affinity DataEC50:  40nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells assessed as reduction in amyloid beta level by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329538BDBM50329538((R,E)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(...)
Affinity DataEC50:  40nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells assessed as reduction in amyloid beta level by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329544BDBM50329544((R)-2-amino-4-(3-(but-1-ynyl)phenyl)-4-(4-(difluor...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
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