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Found 10 Enz. Inhib. hit(s) with all data for entry = 50032646
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332633(CHEMBL1630806 | N-(4-Methylphenyl)-7-oxo-7,7a-dihy...)
Affinity DataKi:  600nMAssay Description:Binding affinity to GFP tagged human mGluR2 containing truncated N-terminal region expressed in HEK cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332634(CHEMBL1630807 | N-(4-Methoxyphenyl)-7-oxo-7,7a-dih...)
Affinity DataKi:  800nMAssay Description:Binding affinity to GFP tagged human mGluR2 containing truncated N-terminal region expressed in HEK cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332632(CHEMBL1630805 | N-(4-Chlorophenyl)-7-oxo-7,7a-dihy...)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity to GFP tagged human mGluR2 containing truncated N-terminal region expressed in HEK cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332631(CHEMBL1630804 | N-(4-Fluorophenyl)-7-oxo-7,7a-dihy...)
Affinity DataKi:  6.60E+3nMAssay Description:Binding affinity to GFP tagged human mGluR2 containing truncated N-terminal region expressed in HEK cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332632(CHEMBL1630805 | N-(4-Chlorophenyl)-7-oxo-7,7a-dihy...)
Affinity DataIC50:  800nMAssay Description:Negative allosteric modulator activity at human mGluR2 expressed in HEK cells in presence of glutamate EC80 concentration by Ca2+ functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332634(CHEMBL1630807 | N-(4-Methoxyphenyl)-7-oxo-7,7a-dih...)
Affinity DataIC50:  1.00E+3nMAssay Description:Negative allosteric modulator activity at human mGluR2 expressed in HEK cells in presence of glutamate EC80 concentration by Ca2+ functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332633(CHEMBL1630806 | N-(4-Methylphenyl)-7-oxo-7,7a-dihy...)
Affinity DataIC50:  1.50E+3nMAssay Description:Negative allosteric modulator activity at human mGluR2 expressed in HEK cells in presence of glutamate EC80 concentration by Ca2+ functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332632(CHEMBL1630805 | N-(4-Chlorophenyl)-7-oxo-7,7a-dihy...)
Affinity DataEC50:  1.34E+4nMAssay Description:Positive allosteric modulator activity at human mGluR3 expressed in HEK cells in presence of glutamate EC10 concentration by Ca2+ functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332633(CHEMBL1630806 | N-(4-Methylphenyl)-7-oxo-7,7a-dihy...)
Affinity DataEC50:  8.90E+3nMAssay Description:Positive allosteric modulator activity at human mGluR3 expressed in HEK cells in presence of glutamate EC10 concentration by Ca2+ functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Domain Therapeutics

Curated by ChEMBL
LigandPNGBDBM50332634(CHEMBL1630807 | N-(4-Methoxyphenyl)-7-oxo-7,7a-dih...)
Affinity DataEC50:  1.04E+4nMAssay Description:Positive allosteric modulator activity at human mGluR3 expressed in HEK cells in presence of glutamate EC10 concentration by Ca2+ functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed