Compile Data Set for Download or QSAR
maximum 50k data
Found 18 Enz. Inhib. hit(s) with all data for entry = 50032760
TargetBile acid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334234((S)-2-(6-chloro-2-(4-chlorophenyl)-5-fluoro-1H-ben...)
Affinity DataIC50:  13nMAssay Description:Displacement of radioligand from human FXR by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334233(2-(2-(4-chlorophenyl)-1H-benzo[d]imidazol-1-yl)-N,...)
Affinity DataIC50:  70nMAssay Description:Displacement of radioligand from human FXR by scintillation proximity assayMore data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334242(2-(2-(4-chlorophenyl)-1H-benzo[d]imidazol-1-yl)-2-...)
Affinity DataIC50:  150nMAssay Description:Displacement of radioligand from human FXR by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334238(2-(2-(4-chlorophenyl)-6-methoxy-1H-benzo[d]imidazo...)
Affinity DataIC50:  450nMAssay Description:Displacement of radioligand from human FXR by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334246(2-(2-(4-chlorophenyl)-1H-benzo[d]imidazol-1-yl)-N-...)
Affinity DataIC50:  910nMAssay Description:Displacement of radioligand from human FXR by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334232(2-(2-(4-cyanophenyl)-1H-benzo[d]imidazol-1-yl)-N,2...)
Affinity DataIC50:  1.25E+3nMAssay Description:Displacement of radioligand from human FXR by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334241(2-(2-(4-chlorophenyl)-1H-benzo[d]imidazol-1-yl)-2-...)
Affinity DataIC50:  2.72E+3nMAssay Description:Displacement of radioligand from human FXR by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334240(2-(2-(4-chlorophenyl)-1H-benzo[d]imidazol-1-yl)-2-...)
Affinity DataIC50:  3.61E+3nMAssay Description:Displacement of radioligand from human FXR by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334239(2-(2-(4-chlorophenyl)-1H-benzo[d]imidazol-1-yl)-2-...)
Affinity DataIC50:  3.71E+3nMAssay Description:Displacement of radioligand from human FXR by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334245(2-(2-(4-chlorophenyl)-1H-benzo[d]imidazol-1-yl)-N-...)
Affinity DataIC50:  3.80E+3nMAssay Description:Displacement of radioligand from human FXR by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334237(2-(2-(4-chlorophenyl)-6-(dimethylamino)-1H-benzo[d...)
Affinity DataIC50:  5.17E+3nMAssay Description:Displacement of radioligand from human FXR by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334236(2-(4-chlorophenyl)-1-(1-cyclohexyl-2-(cyclohexylam...)
Affinity DataIC50:  5.72E+3nMAssay Description:Displacement of radioligand from human FXR by scintillation proximity assayMore data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334235(2-(2-(4-chlorophenyl)-6-(hydroxymethyl)-1H-benzo[d...)
Affinity DataIC50:  6.19E+3nMAssay Description:Displacement of radioligand from human FXR by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334231(CHEMBL1642348 | N,2-dicyclohexyl-2-(2-(4-(methylsu...)
Affinity DataIC50:  1.24E+4nMAssay Description:Displacement of radioligand from human FXR by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334244(2-(4-acetylpiperidin-1-yl)-2-(2-(4-chlorophenyl)-1...)
Affinity DataIC50:  1.48E+4nMAssay Description:Displacement of radioligand from human FXR by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334243(2-(2-(4-chlorophenyl)-1H-benzo[d]imidazol-1-yl)-N-...)
Affinity DataIC50:  2.51E+4nMAssay Description:Displacement of radioligand from human FXR by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334230(CHEMBL1642349 | N,2-dicyclohexyl-2-(2-(pyridin-4-y...)
Affinity DataIC50:  3.04E+4nMAssay Description:Displacement of radioligand from human FXR by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334234((S)-2-(6-chloro-2-(4-chlorophenyl)-5-fluoro-1H-ben...)
Affinity DataEC50:  141nMAssay Description:Agonist activity at human FXR expressed in cells assessed as transactivation by luciferase transcriptional reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed