Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50033488
LigandChemical structure of BindingDB Monomer ID 18425BDBM18425((3R,5R)-7-[1-(4-fluorophenyl)-3-{[(4-methylphenyl)...)
Affinity DataIC50: 1nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50346286BDBM50346286(sodium(3R,5R)-7-(5-cyclopropyl-4-(3-fluorobenzylca...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50346288BDBM50346288(sodium(3R,5R)-7-(5-cyclopropyl-4-(3,4-difluorobenz...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50346282BDBM50346282(sodium(3R,5R)-7-(5-cyclopropyl-2-(4-fluorophenyl)-...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50346283BDBM50346283(sodium(3R,5R)-7-(5-cyclopropyl-2-(4-fluorophenyl)-...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50346289BDBM50346289(sodium(3R,5R)-7-(5-cyclopropyl-4-(2,4-difluorobenz...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50346278BDBM50346278(sodium(3R,5R)-7-(4-(benzylcarbamoyl)-5-cyclopropyl...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50346287BDBM50346287(sodium(3R,5R)-7-(5-cyclopropyl-4-(2-fluorobenzylca...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50346279BDBM50346279(sodium(3R,5R)-7-(5-cyclopropyl-2-(4-fluorophenyl)-...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 18372BDBM18372(CHEMBL1496 | Ros | (3R,5S,6E)-7-[4-(4-fluorophenyl...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50346285BDBM50346285(sodium(3R,5R)-7-(5-cyclopropyl-4-(4-fluorobenzylca...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50346291BDBM50346291(sodium(3R,5R)-7-(5-cyclopropyl-4-(3-fluoro-4-metho...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50346290BDBM50346290(sodium(3R,5R)-7-(5-cyclopropyl-4-(3-fluoro-4-methy...)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50346281BDBM50346281(sodium(3R,5R)-7-(5-cyclopropyl-2-(4-fluorophenyl)-...)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50346293BDBM50346293(sodium(3R,5R)-7-(5-cyclopropyl-4-(4-(N,N-dimethyls...)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50346284BDBM50346284(sodium(3R,5R)-7-(5-cyclopropyl-2-(4-fluorophenyl)-...)
Affinity DataIC50: 7nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50346280BDBM50346280(sodium(3R,5R)-7-(5-cyclopropyl-2-(4-fluorophenyl)-...)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50346292BDBM50346292(sodium(3R,5R)-7-(4-(4-carbamoylbenzylcarbamoyl)-5-...)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50346277BDBM50346277(sodium(3R,5R)-7-(4-(benzylcarbamoyl)-2-(4-fluoroph...)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50346276BDBM50346276(sodium(3R,5R)-7-(4-(benzylcarbamoyl)-2-(4-fluoroph...)
Affinity DataIC50: 26nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50346274BDBM50346274(sodium(3R,5R)-7-(4-(benzylcarbamoyl)-2-(4-fluoroph...)
Affinity DataIC50: 94nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50346275BDBM50346275(sodium(3R,5R)-7-(4-(benzylcarbamoyl)-5-ethyl-2-(4-...)
Affinity DataIC50: 123nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed