Compile Data Set for Download or QSAR
Report error Found 27 Enz. Inhib. hit(s) with all data for entry = 50032990
TargetC-X-C chemokine receptor type 4(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50337581(rac-N1-(1-(4-Methylpyridin-2-yl)ethyl)-N1-(3-methy...)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium signalingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50337584((S)-N1-((3-aminopyridin-2-yl)methyl)-N1-(5,6,7,8-t...)
Affinity DataIC50: 10.9nMAssay Description:Displacement of [125I]SDF-1alpha from CXCR4 in human CEM-CCRF cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50337585((S)-N1-((1H-benzo[d]imidazol-2-yl)methyl)-N1-(1-(p...)
Affinity DataIC50: 16.6nMAssay Description:Displacement of [125I]SDF-1alpha from CXCR4 in human CEM-CCRF cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50337577(rac-N1-(3-iso-Butylpyridin-2-ylmethyl)-N1-(1-pyrid...)
Affinity DataIC50: 18nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium signalingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50337561(rac-N1-(3-methylpyridin-2-ylmethyl)-N1-(5,6,7,8-te...)
Affinity DataIC50: 18nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium signalingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50337566(rac-N'-(3,5-Dimethylpyridin-2-ylmethyl)-N'-(5,6,7,...)
Affinity DataIC50: 19nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium signalingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50337580(rac-N1-(3,5-dimethylpyridin-2-ylmethyl)-N1-(1-pyri...)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium signalingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50337574(racN1-(3-Methylpyridin-2-ylmethyl)-N1-(1-pyridin-2...)
Affinity DataIC50: 23nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium signalingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50337570(rac-N1-(3-Aminopyridin-2-ylmethyl)-N1-(5,6,7,8-tet...)
Affinity DataIC50: 27nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium signalingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50337563(rac-N1-(4-Methylpyridin-2-ylmethyl)-N1-(5,6,7,8-te...)
Affinity DataIC50: 35nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium signalingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50337586((S)-N1-((3-methylpyridin-2-yl)methyl)-N1-(1-(pyrid...)
Affinity DataIC50: 35.8nMAssay Description:Displacement of [125I]SDF-1alpha from CXCR4 in human CEM-CCRF cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50337565(rac-N1-((4,6-dimethylpyridin-2-yl)methyl)-N1-(5,6,...)
Affinity DataIC50: 38nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium signalingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50337573(racN1-(3-chloropyridin-2-ylmethyl)-N1-(5,6,7,8-tet...)
Affinity DataIC50: 44nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium signalingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50337567(rac-N1-(6-aminopyridin-2-ylmethyl)-N1-(5,6,7,8-tet...)
Affinity DataIC50: 49nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium signalingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50337564(rac-N1-(6-Methylpyridin-2-ylmethyl)-N1-(5,6,7,8-te...)
Affinity DataIC50: 53nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium signalingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50337583((S)-N1-((3,5-dimethylpyridin-2-yl)methyl)-N1-(5,6,...)
Affinity DataIC50: 62.9nMAssay Description:Displacement of [125I]SDF-1alpha from CXCR4 in human CEM-CCRF cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50337571(rac-N1-(3-isopropylpyridin-2-ylmethyl)-N1-(5,6,7,8...)
Affinity DataIC50: 63nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium signalingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50337578(rac-N1-((5-methylpyridin-2-yl)methyl)-N1-(1-(pyrid...)
Affinity DataIC50: 66nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium signalingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50337575(rac-N1-((3-aminopyridin-2-yl)methyl)-N1-(1-(pyridi...)
Affinity DataIC50: 72nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium signalingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50337560((+/-)-N1-(pyridine-2-ylmethyl)-N1-(5,6,7,8-tetrahy...)
Affinity DataIC50: 74nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium signalingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50337572(rac-(2-(((4-Aminobutyl)-(5,6,7,8-tetrahydroquinoli...)
Affinity DataIC50: 79nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium signalingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50337562(rac-N1-((4-methylpyridin-2-yl)methyl)-N1-(5,6,7,8-...)
Affinity DataIC50: 91nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium signalingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50337582((S)-N1-((6-methylpyridin-2-yl)methyl)-N1-(5,6,7,8-...)
Affinity DataIC50: 96.1nMAssay Description:Displacement of [125I]SDF-1alpha from CXCR4 in human CEM-CCRF cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50337576(rac-N1-(1-(pyridin-2-yl)ethyl)-N1-((3-(trifluorome...)
Affinity DataIC50: 111nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium signalingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50337569(rac-2-(((4-aminobutyl)(5,6,7,8-tetrahydroquinolin-...)
Affinity DataIC50: 129nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium signalingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50337579(rac-N1-((6-methylpyridin-2-yl)methyl)-N1-(1-(pyrid...)
Affinity DataIC50: 183nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium signalingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50337568(rac-N1-((6-(methoxymethyl)pyridin-2-yl)methyl)-N1-...)
Affinity DataIC50: 1.62E+3nMAssay Description:Antagonist activity at CXCR4 in human CEM-CCRF cells assessed as inhibition of SDF-1-induced calcium signalingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed