Compile Data Set for Download or QSAR
maximum 50k data
Found 91 Enz. Inhib. hit(s) with all data for entry = 50032994
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337654(1-(3-(cyclopropylethynyl)benzyl)-3-isopropyl-1-(3-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337659(1-(3-((4-chlorophenyl)ethynyl)benzyl)-3-isopropyl-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50227631(2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)iso...)
Affinity DataIC50:  1nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337658(1-(3-((4-chlorophenyl)ethynyl)benzyl)-3-isopropyl-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337661(1-(3-((4-chlorophenyl)ethynyl)benzyl)-3-isopropyl-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337657(3-isopropyl-1-(3-(phenylethynyl)benzyl)-1-((5-(phe...)
Affinity DataIC50:  2nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337653(1-(biphenyl-3-ylmethyl)-3-isopropyl-1-(3-(phenylet...)
Affinity DataIC50:  3nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337660(3-isopropyl-1-(3-(pyridin-3-ylethynyl)benzyl)-1-(3...)
Affinity DataIC50:  3nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337656(1-((5-(cyclopentylethynyl)pyridin-3-yl)methyl)-3-i...)
Affinity DataIC50:  3nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337662(1-benzyl-1-(3-(phenylethynyl)benzyl)-3-propylurea ...)
Affinity DataIC50:  8nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337641(1-benzyl-3-isopropyl-1-(3-(phenylethynyl)benzyl)ur...)
Affinity DataIC50:  8nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337646(1-benzyl-3-isopropyl-1-(3-((3-(trifluoromethyl)phe...)
Affinity DataIC50:  9nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337663(1-benzyl-3-cyclobutyl-1-(3-(phenylethynyl)benzyl)u...)
Affinity DataIC50:  12nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337647(1-benzyl-3-isopropyl-1-(3-((4-(trifluoromethyl)phe...)
Affinity DataIC50:  13nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337644(1-benzyl-1-(3-((3-chlorophenyl)ethynyl)benzyl)-3-i...)
Affinity DataIC50:  13nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337652(3-isopropyl-1-(3-methylbenzyl)-1-(3-(phenylethynyl...)
Affinity DataIC50:  15nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337655(1-((5-(cyclopropylethynyl)pyridin-3-yl)methyl)-3-i...)
Affinity DataIC50:  18nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337651(3-isopropyl-1-(3-(phenylethynyl)benzyl)-1-(3-(trif...)
Affinity DataIC50:  18nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337645(1-benzyl-1-(3-((4-chlorophenyl)ethynyl)benzyl)-3-i...)
Affinity DataIC50:  22nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337642(1-benzyl-3-isopropyl-1-(3-((3-methoxyphenyl)ethyny...)
Affinity DataIC50:  27nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337664(1-benzyl-3-(pentan-3-yl)-1-(3-(phenylethynyl)benzy...)
Affinity DataIC50:  31nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337665(1-benzyl-3-cyclopropyl-1-(3-(phenylethynyl)benzyl)...)
Affinity DataIC50:  32nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337670(1-benzyl-3-isopropyl-1-(3-(phenylethynyl)benzyl)th...)
Affinity DataIC50:  43nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337650(3-isopropyl-1-(3-methoxybenzyl)-1-(3-(phenylethyny...)
Affinity DataIC50:  46nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337666(1-benzyl-3-(cyclopropylmethyl)-1-(3-(phenylethynyl...)
Affinity DataIC50:  48nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337643(1-benzyl-3-isopropyl-1-(3-((4-methoxyphenyl)ethyny...)
Affinity DataIC50:  72nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337671(1-benzyl-3-isopropyl-1-(3-((2-methoxyphenyl)ethyny...)
Affinity DataIC50:  150nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337649(3-isopropyl-1-(4-methoxybenzyl)-1-(3-(phenylethyny...)
Affinity DataIC50:  150nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337654(1-(3-(cyclopropylethynyl)benzyl)-3-isopropyl-1-(3-...)
Affinity DataIC50:  160nMAssay Description:Inhibition of mPGES1 in IL-1beta treated human A549 cell microsome assessed as inhibition of PGE2 production after 1 min in presence of 50% FBSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337668(CHEMBL1683226 | tert-butyl(benzyl(3-(phenylethynyl...)
Affinity DataIC50:  190nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337659(1-(3-((4-chlorophenyl)ethynyl)benzyl)-3-isopropyl-...)
Affinity DataIC50:  240nMAssay Description:Inhibition of mPGES1 in IL-1beta treated human A549 cell microsome assessed as inhibition of PGE2 production after 1 min in presence of 50% FBSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337669(1-benzyl-2-cyano-3-isopropyl-1-(3-(phenylethynyl)b...)
Affinity DataIC50:  260nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337660(3-isopropyl-1-(3-(pyridin-3-ylethynyl)benzyl)-1-(3...)
Affinity DataIC50:  330nMAssay Description:Inhibition of mPGES1 in IL-1beta treated human A549 cell microsome assessed as inhibition of PGE2 production after 1 min in presence of 50% FBSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337661(1-(3-((4-chlorophenyl)ethynyl)benzyl)-3-isopropyl-...)
Affinity DataIC50:  340nMAssay Description:Inhibition of mPGES1 in IL-1beta treated human A549 cell microsome assessed as inhibition of PGE2 production after 1 min in presence of 50% FBSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337657(3-isopropyl-1-(3-(phenylethynyl)benzyl)-1-((5-(phe...)
Affinity DataIC50:  360nMAssay Description:Inhibition of mPGES1 in IL-1beta treated human A549 cell microsome assessed as inhibition of PGE2 production after 1 min in presence of 50% FBSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50227631(2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)iso...)
Affinity DataIC50:  420nMAssay Description:Inhibition of mPGES1 in IL-1beta treated human A549 cell microsome assessed as inhibition of PGE2 production after 1 min in presence of 50% FBSMore data for this Ligand-Target Pair
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337658(1-(3-((4-chlorophenyl)ethynyl)benzyl)-3-isopropyl-...)
Affinity DataIC50:  480nMAssay Description:Inhibition of mPGES1 in IL-1beta treated human A549 cell microsome assessed as inhibition of PGE2 production after 1 min in presence of 50% FBSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337656(1-((5-(cyclopentylethynyl)pyridin-3-yl)methyl)-3-i...)
Affinity DataIC50:  490nMAssay Description:Inhibition of mPGES1 in IL-1beta treated human A549 cell microsome assessed as inhibition of PGE2 production after 1 min in presence of 50% FBSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337655(1-((5-(cyclopropylethynyl)pyridin-3-yl)methyl)-3-i...)
Affinity DataIC50:  490nMAssay Description:Inhibition of mPGES1 in IL-1beta treated human A549 cell microsome assessed as inhibition of PGE2 production after 1 min in presence of 50% FBSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337648(3-isopropyl-1-(2-methoxybenzyl)-1-(3-(phenylethyny...)
Affinity DataIC50:  580nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337638(CHEMBL1683194 | N-(3-((1-benzyl-3-isopropylureido)...)
Affinity DataIC50:  660nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337641(1-benzyl-3-isopropyl-1-(3-(phenylethynyl)benzyl)ur...)
Affinity DataIC50:  910nMAssay Description:Inhibition of mPGES1 in IL-1beta treated human A549 cell microsome assessed as inhibition of PGE2 production after 1 min in presence of 50% FBSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337647(1-benzyl-3-isopropyl-1-(3-((4-(trifluoromethyl)phe...)
Affinity DataIC50:  990nMAssay Description:Inhibition of mPGES1 in IL-1beta treated human A549 cell microsome assessed as inhibition of PGE2 production after 1 min in presence of 50% FBSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337639(1-benzyl-1-(3-(benzyloxy)benzyl)-3-isopropylurea |...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337642(1-benzyl-3-isopropyl-1-(3-((3-methoxyphenyl)ethyny...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of mPGES1 in IL-1beta treated human A549 cell microsome assessed as inhibition of PGE2 production after 1 min in presence of 50% FBSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50227631(2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)iso...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of mPGES1 in LPS-stimulated human whole blood assessed as inhibition of PGE2 productionMore data for this Ligand-Target Pair
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337664(1-benzyl-3-(pentan-3-yl)-1-(3-(phenylethynyl)benzy...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of mPGES1 in IL-1beta treated human A549 cell microsome assessed as inhibition of PGE2 production after 1 min in presence of 50% FBSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337669(1-benzyl-2-cyano-3-isopropyl-1-(3-(phenylethynyl)b...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of mPGES1 in IL-1beta treated human A549 cell microsome assessed as inhibition of PGE2 production after 1 min in presence of 50% FBSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337635(1-benzyl-1-(biphenyl-3-ylmethyl)-3-isopropylurea |...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50337646(1-benzyl-3-isopropyl-1-(3-((3-(trifluoromethyl)phe...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of mPGES1 in IL-1beta treated human A549 cell microsome assessed as inhibition of PGE2 production after 1 min in presence of 50% FBSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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