Compile Data Set for Download or QSAR
Report error Found 28 Enz. Inhib. hit(s) with all data for entry = 50033004
TargetBeta-2 adrenergic receptor(Human)
Theravance

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50151720BDBM50151720(CHEMBL605993 | Symbicort | cid_9912089 | N-(2-hydr...)
Affinity DataEC50:  0.190nMAssay Description:Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-2 adrenergic receptor(Human)
Theravance

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50337877BDBM50337877((R)-1-(8-(2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydro...)
Affinity DataEC50:  0.320nMAssay Description:Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Theravance

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25771BDBM25771(salmeterol xinafoate | 4-(1-hydroxy-2-{[6-(4-pheny...)
Affinity DataEC50:  0.330nMAssay Description:Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Theravance

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50337878BDBM50337878((R)-1-(9-(2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydro...)
Affinity DataEC50:  0.360nMAssay Description:Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Theravance

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50318159BDBM50318159(CHEMBL1095777 | 8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-...)
Affinity DataEC50:  0.820nMAssay Description:Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Theravance

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50337885BDBM50337885((1R,2R,4S,5R,7S)-7-(2-Hydroxy-2,2-di-thiophen-2-yl...)
Affinity DataEC50:  0.900nMAssay Description:Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Theravance

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50337886BDBM50337886((R)-1-(7-(2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydro...)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Theravance

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50337878BDBM50337878((R)-1-(9-(2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydro...)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Theravance

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50337876BDBM50337876((R)-1-(3-(2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydro...)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Theravance

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25771BDBM25771(salmeterol xinafoate | 4-(1-hydroxy-2-{[6-(4-pheny...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]-dihydroalprenolol from human beta2-adrenoceptor expressed in HEK cells after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Theravance

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50337880BDBM50337880((R)-1-(9-(2-(3-formamido-4-hydroxyphenyl)-2-hydrox...)
Affinity DataEC50:  2.60nMAssay Description:Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Theravance

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50337882BDBM50337882(2-((3S)-1-(9-(2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dih...)
Affinity DataEC50:  3.30nMAssay Description:Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Theravance

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50337877BDBM50337877((R)-1-(8-(2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydro...)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]-dihydroalprenolol from human beta2-adrenoceptor expressed in HEK cells after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Theravance

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50337878BDBM50337878((R)-1-(9-(2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydro...)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]-dihydroalprenolol from human beta2-adrenoceptor expressed in HEK cells after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Theravance

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50337883BDBM50337883(1-(biphenyl-2-yl)-3-(1-(9-(2-hydroxy-2-(8-hydroxy-...)
Affinity DataEC50:  8.40nMAssay Description:Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Theravance

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50337884BDBM50337884((3R)-3-(biphenyl-2-ylcarbamoyloxy)-1-(9-(2-hydroxy...)
Affinity DataEC50:  8.90nMAssay Description:Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Theravance

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50337886BDBM50337886((R)-1-(7-(2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydro...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-dihydroalprenolol from human beta2-adrenoceptor expressed in HEK cells after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Theravance

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50337878BDBM50337878((R)-1-(9-(2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydro...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]-dihydroalprenolol from human beta2-adrenoceptor expressed in HEK cells after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Theravance

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50337881BDBM50337881((R)-1-(9-(2-hydroxy-2-(4-hydroxy-3-(hydroxymethyl)...)
Affinity DataEC50:  14nMAssay Description:Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Theravance

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50337876BDBM50337876((R)-1-(3-(2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydro...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]-dihydroalprenolol from human beta2-adrenoceptor expressed in HEK cells after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Theravance

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50337880BDBM50337880((R)-1-(9-(2-(3-formamido-4-hydroxyphenyl)-2-hydrox...)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]-dihydroalprenolol from human beta2-adrenoceptor expressed in HEK cells after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Theravance

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50151720BDBM50151720(CHEMBL605993 | Symbicort | cid_9912089 | N-(2-hydr...)
Affinity DataKi:  33nMAssay Description:Displacement of [3H]-dihydroalprenolol from human beta2-adrenoceptor expressed in HEK cells after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-2 adrenergic receptor(Human)
Theravance

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50337885BDBM50337885((1R,2R,4S,5R,7S)-7-(2-Hydroxy-2,2-di-thiophen-2-yl...)
Affinity DataKi:  36nMAssay Description:Displacement of [3H]-dihydroalprenolol from human beta2-adrenoceptor expressed in HEK cells after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Theravance

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50337882BDBM50337882(2-((3S)-1-(9-(2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dih...)
Affinity DataKi:  60nMAssay Description:Displacement of [3H]-dihydroalprenolol from human beta2-adrenoceptor expressed in HEK cells after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Theravance

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50318159BDBM50318159(CHEMBL1095777 | 8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-...)
Affinity DataKi:  61nMAssay Description:Displacement of [3H]-dihydroalprenolol from human beta2-adrenoceptor expressed in HEK cells after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Theravance

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50337881BDBM50337881((R)-1-(9-(2-hydroxy-2-(4-hydroxy-3-(hydroxymethyl)...)
Affinity DataKi:  61nMAssay Description:Displacement of [3H]-dihydroalprenolol from human beta2-adrenoceptor expressed in HEK cells after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Theravance

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50337883BDBM50337883(1-(biphenyl-2-yl)-3-(1-(9-(2-hydroxy-2-(8-hydroxy-...)
Affinity DataKi:  115nMAssay Description:Displacement of [3H]-dihydroalprenolol from human beta2-adrenoceptor expressed in HEK cells after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Theravance

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50337884BDBM50337884((3R)-3-(biphenyl-2-ylcarbamoyloxy)-1-(9-(2-hydroxy...)
Affinity DataKi:  123nMAssay Description:Displacement of [3H]-dihydroalprenolol from human beta2-adrenoceptor expressed in HEK cells after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed