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Found 12 Enz. Inhib. hit(s) with all data for entry = 50033015
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50338167((R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluo...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to Cav3.3 alpha1iMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50338166((R)-2-(4-tert-butylphenyl)-N-(1-(5-methoxypyridin-...)
Affinity DataKi:  5nMAssay Description:Antagonist activity at Cav3.3 alpha1i expressed in HEK293 cells at -100 mV by standard voltage-clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50338167((R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluo...)
Affinity DataIC50:  3.70nMAssay Description:Antagonist activity at Cav3.3 alpha1i expressed in HEK293 cells at -100 mV by standard voltage-clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50338167((R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluo...)
Affinity DataIC50:  89nMAssay Description:Inhibition of Cav3.1 alpha1G at -80 mV holding potential by tandard voltage-clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50338167((R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluo...)
Affinity DataIC50:  92nMAssay Description:Inhibition of Cav3.2 alpha1H at -80 mV holding potential by tandard voltage-clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50338167((R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluo...)
Affinity DataIC50:  98nMAssay Description:Antagonist activity at Cav3.3 alpha1i expressed in HEK293 cells at -80 mV by standard voltage-clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50338167((R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluo...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50338166((R)-2-(4-tert-butylphenyl)-N-(1-(5-methoxypyridin-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50338167((R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluo...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of L-type Cav1.2 at -80 mV holding potential by tandard voltage-clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent P/Q-type calcium channel subunit alpha-1A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50338167((R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluo...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of P/Q-type Cav2.1 at -80 mV holding potential by tandard voltage-clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50338167((R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluo...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of N-type Cav2.2 at -80 mV holding potential by tandard voltage-clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent R-type calcium channel subunit alpha-1E(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50338167((R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluo...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of R-type Cav2.3 at -80 mV holding potential by tandard voltage-clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed