Compile Data Set for Download or QSAR
Report error Found 40 Enz. Inhib. hit(s) with all data for entry = 50033027
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338379BDBM50338379(3-(methylsulfinyl)-N-((S)-1-phenylpropyl)-2-(thiop...)
Affinity DataEC50:  1.70nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338380BDBM50338380(3-(methylsulfinyl)-N-((S)-1-phenylpropyl)-2-(thiop...)
Affinity DataEC50:  1.80nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338372BDBM50338372(3-((R)-methylsulfinylmethyl)-2-phenyl-N-((S)-1-phe...)
Affinity DataEC50:  1.80nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338374BDBM50338374((S)-3-(methylsulfonylmethyl)-2-phenyl-N-(1-phenylp...)
Affinity DataEC50:  2.5nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338375BDBM50338375(3-(2-(methylsulfinyl)ethyl)-2-phenyl-N-((S)-1-phen...)
Affinity DataEC50:  3.30nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338396BDBM50338396(7-methyl-3-(methylsulfinyl)-2-phenyl-N-((S)-1-phen...)
Affinity DataEC50:  3.60nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338369BDBM50338369(3-((S)-methylsulfinyl)-2-phenyl-N-((S)-1-phenylpro...)
Affinity DataEC50:  3.70nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338368BDBM50338368(3-(methylsulfinyl)-2-phenyl-N-((S)-1-phenylpropyl)...)
Affinity DataEC50:  4.90nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338368BDBM50338368(3-(methylsulfinyl)-2-phenyl-N-((S)-1-phenylpropyl)...)
Affinity DataEC50:  4.90nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338395BDBM50338395(7-bromo-3-(methylsulfinyl)-2-phenyl-N-((S)-1-pheny...)
Affinity DataEC50:  5.10nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338373BDBM50338373(3-((S)-methylsulfinylmethyl)-2-phenyl-N-((S)-1-phe...)
Affinity DataEC50:  5.30nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338386BDBM50338386(3-(ethylsulfinyl)-2-phenyl-N-((S)-1-phenylpropyl)q...)
Affinity DataEC50:  6.90nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338392BDBM50338392(7-chloro-3-(methylsulfinyl)-2-phenyl-N-((S)-1-phen...)
Affinity DataEC50:  7.70nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338389BDBM50338389(8-fluoro-3-(methylsulfinyl)-2-phenyl-N-((S)-1-phen...)
Affinity DataEC50:  8.20nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338388BDBM50338388(3-(2-(dimethylamino)-2-oxoethylsulfinyl)-2-phenyl-...)
Affinity DataEC50:  12nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338391BDBM50338391(7-fluoro-3-(methylsulfinyl)-2-phenyl-N-((S)-1-phen...)
Affinity DataEC50:  13nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338370BDBM50338370((S)-3-(methylsulfonyl)-2-phenyl-N-(1-phenylpropyl)...)
Affinity DataEC50:  14nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338398BDBM50338398(N-((S)-cyclopropyl(phenyl)methyl)-3-(methylsulfiny...)
Affinity DataEC50:  15nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338387BDBM50338387(3-(isopropylsulfinyl)-2-phenyl-N-((S)-1-phenylprop...)
Affinity DataEC50:  16nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338399BDBM50338399(3-(methylsulfinyl)-2-phenyl-N-(1-phenylcyclopropyl...)
Affinity DataEC50:  16nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338377BDBM50338377(2-(3-fluorophenyl)-3-(methylsulfinyl)-N-((S)-1-phe...)
Affinity DataEC50:  18nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338371BDBM50338371((S)-3-(methylthiomethyl)-2-phenyl-N-(1-phenylpropy...)
Affinity DataEC50:  35nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338367BDBM50338367((S)-3-(methylthio)-2-phenyl-N-(1-phenylpropyl)quin...)
Affinity DataEC50:  36nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338400BDBM50338400(3-(methylsulfinyl)-2-phenyl-N-(1-phenylcyclobutyl)...)
Affinity DataEC50:  38nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338393BDBM50338393(7-ethoxy-3-(methylsulfinyl)-2-phenyl-N-((S)-1-phen...)
Affinity DataEC50:  38nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338378BDBM50338378(2-(4-fluorophenyl)-3-(methylsulfinyl)-N-((S)-1-phe...)
Affinity DataEC50:  48nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338402BDBM50338402(3-(methylsulfinyl)-2-phenyl-N-((S)-1-(pyridin-3-yl...)
Affinity DataEC50:  74nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338403BDBM50338403(3-(methylsulfinyl)-2-phenyl-N-((S)-1-(pyridin-2-yl...)
Affinity DataEC50:  77nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338376BDBM50338376(2-(2-fluorophenyl)-3-(methylsulfinyl)-N-((S)-1-phe...)
Affinity DataEC50:  81nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338397BDBM50338397(7-((dimethylamino)methyl)-3-(methylsulfinyl)-2-phe...)
Affinity DataEC50:  88nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338383BDBM50338383(3-(methylsulfinyl)-N-((S)-1-phenylpropyl)-2-(thiaz...)
Affinity DataEC50:  110nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338394BDBM50338394(7-(dimethylamino)-3-(methylsulfinyl)-2-phenyl-N-((...)
Affinity DataEC50:  212nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338384BDBM50338384(3-(methylsulfinyl)-N-((S)-1-phenylpropyl)-2-(thiaz...)
Affinity DataEC50:  220nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338382BDBM50338382(3-(methylsulfinyl)-N-((S)-1-phenylpropyl)-2-(pyrid...)
Affinity DataEC50:  690nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338381BDBM50338381(3-(methylsulfinyl)-N-((S)-1-phenylpropyl)-2-(pyrid...)
Affinity DataEC50:  1.12E+3nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338390BDBM50338390(8-methyl-3-(methylsulfinyl)-2-phenyl-N-((S)-1-phen...)
Affinity DataEC50:  1.90E+3nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338385BDBM50338385(3-(methylsulfinyl)-N-((S)-1-phenylpropyl)-2-(1H-py...)
Affinity DataEC50:  2.50E+3nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338403BDBM50338403(3-(methylsulfinyl)-2-phenyl-N-((S)-1-(pyridin-2-yl...)
Affinity DataEC50: >5.20E+3nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338401BDBM50338401(N-((S)-cyclopropyl(pyridin-4-yl)methyl)-3-(methyls...)
Affinity DataEC50: >9.30E+3nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338401BDBM50338401(N-((S)-cyclopropyl(pyridin-4-yl)methyl)-3-(methyls...)
Affinity DataEC50: >1.00E+4nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed