Compile Data Set for Download or QSAR
maximum 50k data
Found 24 Enz. Inhib. hit(s) with all data for entry = 50033034
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338523(CHEMBL1683578 | N-(1-methyl-1H-pyrazol-3-yl)-1-(3-...)
Affinity DataIC50:  11nMAssay Description:Inhibition of rat liver SCD1 using [3H]-stearoylCoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338522(5-methyl-N-(1-methyl-1H-pyrazol-3-yl)-1-(3-(triflu...)
Affinity DataIC50:  11.8nMAssay Description:Inhibition of rat liver SCD1 using [3H]-stearoylCoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338524(1-(4-chloro-3-(trifluoromethyl)benzyl)-N-(1-methyl...)
Affinity DataIC50:  16nMAssay Description:Inhibition of rat liver SCD1 using [3H]-stearoylCoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338525(CHEMBL1683580 | N-(2-methyl-2H-1,2,3-triazol-4-yl)...)
Affinity DataIC50:  25nMAssay Description:Inhibition of rat liver SCD1 using [3H]-stearoylCoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338521(CHEMBL1683576 | N-(1-methyl-1H-pyrazol-3-yl)-1-(3-...)
Affinity DataIC50:  32nMAssay Description:Inhibition of rat liver SCD1 using [3H]-stearoylCoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338532(1-(4-chloro-3-(trifluoromethyl)benzyl)-N-(1-methyl...)
Affinity DataIC50:  33nMAssay Description:Inhibition of rat liver SCD1 using [3H]-stearoylCoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338526(1-(3-chlorobenzyl)-N-(1-methyl-1H-pyrazol-3-yl)-1H...)
Affinity DataIC50:  57nMAssay Description:Inhibition of rat liver SCD1 using [3H]-stearoylCoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338527(1-(4-chloro-3-(trifluoromethyl)benzyl)-N-(1-methyl...)
Affinity DataIC50:  63nMAssay Description:Inhibition of rat liver SCD1 using [3H]-stearoylCoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338531(1-(4-chloro-3-(trifluoromethyl)benzyl)-N-(1-methyl...)
Affinity DataIC50:  63nMAssay Description:Inhibition of rat liver SCD1 using [3H]-stearoylCoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338520(1-(4-chlorobenzyl)-N-(diaminomethylene)-5-methyl-1...)
Affinity DataIC50:  68nMAssay Description:Inhibition of rat liver SCD1 assessed as formation of deuterated oleoylCoA by HTMS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338521(CHEMBL1683576 | N-(1-methyl-1H-pyrazol-3-yl)-1-(3-...)
Affinity DataIC50:  88nMAssay Description:Inhibition of human SCD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338520(1-(4-chlorobenzyl)-N-(diaminomethylene)-5-methyl-1...)
Affinity DataIC50:  94nMAssay Description:Inhibition of rat liver SCD1 using [3H]-stearoylCoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338528(1-((1-(cyclopropylmethyl)cyclobutyl)methyl)-N-(1-m...)
Affinity DataIC50:  101nMAssay Description:Inhibition of rat liver SCD1 using [3H]-stearoylCoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338533(CHEMBL1683588 | N-(1-methyl-1H-pyrazol-3-yl)-1-(3-...)
Affinity DataIC50:  113nMAssay Description:Inhibition of rat liver SCD1 using [3H]-stearoylCoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338529(1-(2-chlorophenethyl)-N-(1-methyl-1H-pyrazol-3-yl)...)
Affinity DataIC50:  126nMAssay Description:Inhibition of rat liver SCD1 using [3H]-stearoylCoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338520(1-(4-chlorobenzyl)-N-(diaminomethylene)-5-methyl-1...)
Affinity DataIC50:  217nMAssay Description:Inhibition of human SCD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338534(CHEMBL1683589 | N-(1-methyl-1H-pyrazol-3-yl)-1-(3-...)
Affinity DataIC50:  2.14E+3nMAssay Description:Inhibition of rat liver SCD1 using [3H]-stearoylCoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338530(CHEMBL1683585 | N-(2-acetamidoethyl)-1-(4-fluoro-3...)
Affinity DataIC50:  2.75E+3nMAssay Description:Inhibition of rat liver SCD1 using [3H]-stearoylCoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338522(5-methyl-N-(1-methyl-1H-pyrazol-3-yl)-1-(3-(triflu...)
Affinity DataIC50:  2.89E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338522(5-methyl-N-(1-methyl-1H-pyrazol-3-yl)-1-(3-(triflu...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338522(5-methyl-N-(1-methyl-1H-pyrazol-3-yl)-1-(3-(triflu...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338522(5-methyl-N-(1-methyl-1H-pyrazol-3-yl)-1-(3-(triflu...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338522(5-methyl-N-(1-methyl-1H-pyrazol-3-yl)-1-(3-(triflu...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338522(5-methyl-N-(1-methyl-1H-pyrazol-3-yl)-1-(3-(triflu...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed