Compile Data Set for Download or QSAR
maximum 50k data
Found 16 Enz. Inhib. hit(s) with all data for entry = 50033327
TargetSonic hedgehog protein(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human SHH pathway in mouse S12 cells assessed as GLI-mediated transcriptional activity after 48 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataIC50:  1.75E+3nMAssay Description:Inhibition of human SHH pathway in mouse S12 cells assessed as GLI-mediated transcriptional activity after 48 hrs by luciferase reporter gene assay i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlbumin(Rattus norvegicus)
Genentech

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataKd:  1.71E+5nMAssay Description:Binding affinity to high-affinity binding site of rat serum albumin at 20 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlbumin(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50343352(2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...)
Affinity DataKd:  5.10E+5nMAssay Description:Binding affinity to high-affinity binding site of human serum albumin at 20 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetAlbumin(Rattus norvegicus)
Genentech

Curated by ChEMBL
LigandPNGBDBM50343352(2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...)
Affinity DataKd:  9.00E+5nMAssay Description:Binding affinity to high-affinity binding site of rat serum albumin at 20 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlbumin(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50343352(2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...)
Affinity DataKd:  5.40E+3nMAssay Description:Binding affinity to low-affinity binding site of human serum albumin at 20 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetAlbumin(Rattus norvegicus)
Genentech

Curated by ChEMBL
LigandPNGBDBM50343352(2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...)
Affinity DataKd:  2.00E+4nMAssay Description:Binding affinity to low-affinity binding site of rat serum albumin at 20 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlbumin(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50343352(2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...)
Affinity DataKd:  2.00E+3nMAssay Description:Binding affinity to human serum albumin at 20 degC by isothermal titration calorimetry analysisMore data for this Ligand-Target Pair
TargetAlbumin(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataKd:  5.50E+3nMAssay Description:Binding affinity to human serum albumin at 20 degC by isothermal titration calorimetry analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAlbumin(Rattus norvegicus)
Genentech

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataKd:  5.80E+3nMAssay Description:Binding affinity to low-affinity binding site of rat serum albumin at 20 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlbumin(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataKd:  6.00E+3nMAssay Description:Binding affinity to low-affinity binding site of human serum albumin at 20 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAlbumin(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50343352(2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...)
Affinity DataKd:  1.20E+4nMAssay Description:Binding affinity to human serum albumin at 37 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetAlbumin(Rattus norvegicus)
Genentech

Curated by ChEMBL
LigandPNGBDBM50343352(2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...)
Affinity DataKd:  9.50E+4nMAssay Description:Binding affinity to rat serum albumin at 37 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlbumin(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataKd:  1.20E+5nMAssay Description:Binding affinity to human serum albumin at 37 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAlbumin(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataKd:  1.30E+5nMAssay Description:Binding affinity to high-affinity binding site of human serum albumin at 20 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAlbumin(Rattus norvegicus)
Genentech

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataKd:  1.40E+5nMAssay Description:Binding affinity to rat serum albumin at 37 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed