Compile Data Set for Download or QSAR
Report error Found 219 Enz. Inhib. hit(s) with all data for entry = 50033446
LigandPNGBDBM50345537(N-(4-((4-(4-chloro-2-methylphenethyl)piperidin-1-y...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345535(N-(1-(cyclobutanecarbonyl)-4-((4-(2-methyl-4-(trif...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345534(N-(4-((4-(2-cyclopropyl-4-(methylsulfonyl)phenethy...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345539(N-(1-(cyclobutanecarbonyl)-4-((4-(4-fluoro-2-methy...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345533(N-(4-((4-(4-chloro-2-methylphenethyl)piperidin-1-y...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345538(N-(1-(cyclobutanecarbonyl)-4-((4-(2-methylphenethy...)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345514(N-(4-((4-(4-fluoro-2-methylphenethyl)piperidin-1-y...)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345507(N-hydroxy-N-(4-((4-(2-methylphenethyl)piperidin-1-...)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345504(N-hydroxy-N-(4-((4-(2-methyl-4-(methylsulfonyl)phe...)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345536(N-(1-(cyclobutanecarbonyl)-4-((4-(4-fluoro-2-(trif...)
Affinity DataIC50: 8.70nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345524(N-(4-((4-(2-(3,5-dimethylisoxazol-4-yl)ethyl)piper...)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345520(N-(1-(cyclobutanecarbonyl)-4-((4-(2-(3,5-dimethyli...)
Affinity DataIC50: 10nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345539(N-(1-(cyclobutanecarbonyl)-4-((4-(4-fluoro-2-methy...)
Affinity DataIC50: 11nMAssay Description:Inhibition of ADAMTS-5 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345516(N-(1-(azetidine-1-carbonyl)-4-((4-(2-(3,5-dimethyl...)
Affinity DataIC50: 11nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345511(N-(4-((4-(2-(3,5-dimethylisothiazol-4-yl)ethyl)pip...)
Affinity DataIC50: 13nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345538(N-(1-(cyclobutanecarbonyl)-4-((4-(2-methylphenethy...)
Affinity DataIC50: 13nMAssay Description:Inhibition of ADAMTS-5 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345522(N-(4-{4-[2-(3,5-Dimethyl-isoxazol-4-yl)-ethyl]-pip...)
Affinity DataIC50: 16nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345513(N-(4-((4-(2-(2,5-dimethylpyridin-4-yl)ethyl)piperi...)
Affinity DataIC50: 18nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345525(N-(4-((4-(2-(3,5-dimethylisoxazol-4-yl)ethyl)piper...)
Affinity DataIC50: 19nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345521(N-(1-((4-(2-(3,5-dimethylisoxazol-4-yl)ethyl)piper...)
Affinity DataIC50: 20nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345527(N-(1-((4-(2-(3,5-dimethylisoxazol-4-yl)ethyl)piper...)
Affinity DataIC50: 20nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345537(N-(4-((4-(4-chloro-2-methylphenethyl)piperidin-1-y...)
Affinity DataIC50: 20nMAssay Description:Inhibition of ADAMTS-5 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345532(N-(4-((4-(4-fluorophenyl)piperazin-1-ylsulfonyl)me...)
Affinity DataIC50: 21nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50337735(N-[(2S,4S)-1-({4-[2-(3,5-dimethyl-1,2-oxazol-4-yl)...)
Affinity DataIC50: 23nMAssay Description:Inhibition of ADAMTS-5 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345523(N-(1-acetyl-4-((4-(2-(3,5-dimethylisoxazol-4-yl)et...)
Affinity DataIC50: 24nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345515(N-(4-((4-(2-(3,5-dimethylisoxazol-4-yl)ethyl)piper...)
Affinity DataIC50: 26nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345517(N-(4-((4-(2-(3,5-dimethylisoxazol-4-yl)ethyl)piper...)
Affinity DataIC50: 29nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345507(N-hydroxy-N-(4-((4-(2-methylphenethyl)piperidin-1-...)
Affinity DataIC50: 31nMAssay Description:Inhibition of ADAMTS-5 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345519(N-(1-((4-(2-(3,5-dimethylisoxazol-4-yl)ethyl)piper...)
Affinity DataIC50: 48nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345518(N-(1-((4-(2-(3,5-dimethylisoxazol-4-yl)ethyl)piper...)
Affinity DataIC50: 51nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345526(N-(1-((4-(2-(3,5-dimethylisoxazol-4-yl)ethyl)piper...)
Affinity DataIC50: 52nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345536(N-(1-(cyclobutanecarbonyl)-4-((4-(4-fluoro-2-(trif...)
Affinity DataIC50: 61nMAssay Description:Inhibition of ADAMTS-5 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345533(N-(4-((4-(4-chloro-2-methylphenethyl)piperidin-1-y...)
Affinity DataIC50: 65nMAssay Description:Inhibition of ADAMTS-5 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345514(N-(4-((4-(4-fluoro-2-methylphenethyl)piperidin-1-y...)
Affinity DataIC50: 69nMAssay Description:Inhibition of ADAMTS-5 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345535(N-(1-(cyclobutanecarbonyl)-4-((4-(2-methyl-4-(trif...)
Affinity DataIC50: 79nMAssay Description:Inhibition of ADAMTS-5 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345530(N-(1-((4-(4-fluorophenyl)piperazin-1-ylsulfonyl)me...)
Affinity DataIC50: 91nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345529(N-(1-(4-(4-fluorophenyl)piperazin-1-ylsulfonyl)-2-...)
Affinity DataIC50: 92nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345508(N-hydroxy-N-(4-((4-(2-(3-methylpyridin-2-yl)ethyl)...)
Affinity DataIC50: 100nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345505(N-hydroxy-N-(4-((4-(2-(4-methylpyridin-3-yl)ethyl)...)
Affinity DataIC50: 110nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345510(N-(4-((4-(2-(4,6-dimethylpyridin-3-yl)ethyl)piperi...)
Affinity DataIC50: 130nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345506(N-hydroxy-N-(4-((4-phenethylpiperidin-1-ylsulfonyl...)
Affinity DataIC50: 150nMAssay Description:Inhibition of recombinant human MMP-2 assessed as substrate cleavage after 20 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345528(rac-N-(1-(4-(4-fluorophenyl)piperazin-1-ylsulfonyl...)
Affinity DataIC50: 154nMAssay Description:Inhibition of recombinant human MMP-13 assessed as substrate cleavage after 20 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345528(rac-N-(1-(4-(4-fluorophenyl)piperazin-1-ylsulfonyl...)
Affinity DataIC50: 226nMAssay Description:Inhibition of recombinant human MMP-14 assessed as substrate cleavage after 20 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345524(N-(4-((4-(2-(3,5-dimethylisoxazol-4-yl)ethyl)piper...)
Affinity DataIC50: 250nMAssay Description:Inhibition of ADAMTS-5 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345506(N-hydroxy-N-(4-((4-phenethylpiperidin-1-ylsulfonyl...)
Affinity DataIC50: 260nMAssay Description:Inhibition of recombinant human MMP-13 assessed as substrate cleavage after 20 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345520(N-(1-(cyclobutanecarbonyl)-4-((4-(2-(3,5-dimethyli...)
Affinity DataIC50: 270nMAssay Description:Inhibition of ADAMTS-5 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345522(N-(4-{4-[2-(3,5-Dimethyl-isoxazol-4-yl)-ethyl]-pip...)
Affinity DataIC50: 270nMAssay Description:Inhibition of ADAMTS-5 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345517(N-(4-((4-(2-(3,5-dimethylisoxazol-4-yl)ethyl)piper...)
Affinity DataIC50: 310nMAssay Description:Inhibition of ADAMTS-5 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345512(N-(4-((4-(2-(2,5-dimethylpyridin-3-yl)ethyl)piperi...)
Affinity DataIC50: 380nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345509(N-hydroxy-N-(4-((4-(2-(2-methylpyridin-3-yl)ethyl)...)
Affinity DataIC50: 400nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
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