Compile Data Set for Download or QSAR
maximum 50k data
Found 6 Enz. Inhib. hit(s) with all data for entry = 50034116
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universiti Putra Malaysia

Curated by ChEMBL
LigandPNGBDBM22372(4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbut...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human 5-LOX in human peripheral blood mononuclear leukocytes assessed as inhibition of calymycin A23187-stimulated LTB4 production prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Universiti Putra Malaysia

Curated by ChEMBL
LigandPNGBDBM50357364(CHEMBL1242095)
Affinity DataIC50:  400nMAssay Description:Inhibition of human recombinant COX2 expressed in insect Sf21 cells assessed as inhibition of conversion of arachidonic acid to PGE2 preincubated for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Universiti Putra Malaysia

Curated by ChEMBL
LigandPNGBDBM22372(4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbut...)
Affinity DataIC50:  400nMAssay Description:Inhibition of 5-LOX in calcium ionophore A23187-stimulated NMRI mouse macrophage assessed as inhibition of LTC4 production preincubated for 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universiti Putra Malaysia

Curated by ChEMBL
LigandPNGBDBM50357364(CHEMBL1242095)
Affinity DataIC50:  420nMAssay Description:Inhibition of human 5-LOX in human peripheral blood mononuclear leukocytes assessed as inhibition of calymycin A23187-stimulated LTB4 production prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Universiti Putra Malaysia

Curated by ChEMBL
LigandPNGBDBM50357364(CHEMBL1242095)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of 5-LOX in calcium ionophore A23187-stimulated NMRI mouse macrophage assessed as inhibition of LTC4 production preincubated for 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Universiti Putra Malaysia

Curated by ChEMBL
LigandPNGBDBM50357364(CHEMBL1242095)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition of COX1 in human platelets assessed as inhibition of conversion of arachidonic acid to PGE2 preincubated for 15 mins before substrate addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed