Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 50034496
TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25391([2-(4-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-ind...)
Affinity DataKi:  0.160nMAssay Description:Inhibition of N-terminus His-6 tagged human B-Raf expressed in baculovirus infected insect Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50363398(CHEMBL1946171)
Affinity DataIC50: 3nMAssay Description:Inhibition of C-RafMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50363398(CHEMBL1946171)
Affinity DataIC50: 3nMAssay Description:Inhibition of wild-type B-RafMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataIC50: 13nMAssay Description:Inhibition of wild-type B-RafMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 28nMAssay Description:Inhibition of wild-type B-RafMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50363398(CHEMBL1946171)
Affinity DataIC50: 30nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25391([2-(4-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-ind...)
Affinity DataEC50:  1.10E+3nMAssay Description:Inhibition of B-Raf-mediated Erk phosphorylation in human PREC cells after 60 mins by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25391([2-(4-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-ind...)
Affinity DataEC50:  1.10E+3nMAssay Description:Inhibition of B-Raf-mediated Erk phosphorylation in human HMEC cells after 60 mins by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25391([2-(4-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-ind...)
Affinity DataEC50:  1.10E+3nMAssay Description:Inhibition of B-Raf-mediated Erk phosphorylation in human HFF cells after 60 mins by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed