Compile Data Set for Download or QSAR
Report error Found 40 Enz. Inhib. hit(s) with all data for entry = 50045933
TargetCytochrome P450 2C19(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50225074(CHEMBL385517 | BMS-477118 | (1S,6S)-2-(2-adamantan...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes assessed as (S)-mephenytoin 4'-hydroxylation after 3 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50225074(CHEMBL385517 | BMS-477118 | (1S,6S)-2-(2-adamantan...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes assessed as (S)-mephenytoin 4'-hydroxylation preincubated for 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50225074(CHEMBL385517 | BMS-477118 | (1S,6S)-2-(2-adamantan...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as bufuralol 1'-hydroxylation after 3 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50225074(CHEMBL385517 | BMS-477118 | (1S,6S)-2-(2-adamantan...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as bufuralol 1'-hydroxylation preincubated for 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50225074(CHEMBL385517 | BMS-477118 | (1S,6S)-2-(2-adamantan...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2E1 in human liver microsomes assessed as chlorzoxazone 6-hydroxylation after 3 mins by LC-MS/MS analysis in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50225074(CHEMBL385517 | BMS-477118 | (1S,6S)-2-(2-adamantan...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as midazolam 1'-hydroxylation after 3 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50225074(CHEMBL385517 | BMS-477118 | (1S,6S)-2-(2-adamantan...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2E1 in human liver microsomes assessed as chlorzoxazone 6-hydroxylation preincubated for 15 mins by LC-MS/MS analysis in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50225074(CHEMBL385517 | BMS-477118 | (1S,6S)-2-(2-adamantan...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as testosterone 6beta-hydroxylation after 3 mins by LC-MS/MS analysis in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50225074(CHEMBL385517 | BMS-477118 | (1S,6S)-2-(2-adamantan...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes assessed as phenacetin O-deethylation after 3 mins by LC-MS/MS analysis in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50225074(CHEMBL385517 | BMS-477118 | (1S,6S)-2-(2-adamantan...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes assessed as phenacetin O-deethylation preincubated for 15 mins by LC-MS/MS analysis in presence of NAD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50225074(CHEMBL385517 | BMS-477118 | (1S,6S)-2-(2-adamantan...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as midazolam 1'-hydroxylation preincubated for 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2A6(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50225074(CHEMBL385517 | BMS-477118 | (1S,6S)-2-(2-adamantan...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2A6 in human liver microsomes assessed as coumarin 7-hydroxylation preincubated for 15 mins by LC-MS/MS analysis in presence of NADP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2A6(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50225074(CHEMBL385517 | BMS-477118 | (1S,6S)-2-(2-adamantan...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2A6 in human liver microsomes assessed as coumarin 7-hydroxylation after 3 mins by LC-MS/MS analysis in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50225074(CHEMBL385517 | BMS-477118 | (1S,6S)-2-(2-adamantan...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes assessed as bupropion hydroxylation after 3 mins by LC-MS/MS analysis in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50225074(CHEMBL385517 | BMS-477118 | (1S,6S)-2-(2-adamantan...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes assessed as bupropion hydroxylation preincubated for 15 mins by LC-MS/MS analysis in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50225074(CHEMBL385517 | BMS-477118 | (1S,6S)-2-(2-adamantan...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as testosterone 6beta-hydroxylation preincubated for 15 mins by LC-MS/MS analysis in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50225074(CHEMBL385517 | BMS-477118 | (1S,6S)-2-(2-adamantan...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes assessed as paclitaxel 6alpha-hydroxylation after 3 mins by LC-MS/MS analysis in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50225074(CHEMBL385517 | BMS-477118 | (1S,6S)-2-(2-adamantan...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes assessed as paclitaxel 6alpha-hydroxylation preincubated for 15 mins by LC-MS/MS analysis in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50225074(CHEMBL385517 | BMS-477118 | (1S,6S)-2-(2-adamantan...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as paclitaxel 6alpha-hydroxylation after 3 mins by LC-MS/MS analysis in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50225074(CHEMBL385517 | BMS-477118 | (1S,6S)-2-(2-adamantan...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as paclitaxel 6alpha-hydroxylation preincubated for 15 mins by LC-MS/MS analysis in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM11543((S)-3,5-Dihydroxyadamantylglycine-L-cis-4,5-methan...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP2C19 in human liver microsomes assessed as (S)-mephenytoin 4'-hydroxylation after 3 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM11543((S)-3,5-Dihydroxyadamantylglycine-L-cis-4,5-methan...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP2C19 in human liver microsomes assessed as (S)-mephenytoin 4'-hydroxylation preincubated for 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM11543((S)-3,5-Dihydroxyadamantylglycine-L-cis-4,5-methan...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as bufuralol 1'-hydroxylation after 3 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM11543((S)-3,5-Dihydroxyadamantylglycine-L-cis-4,5-methan...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP2E1 in human liver microsomes assessed as chlorzoxazone 6-hydroxylation after 3 mins by LC-MS/MS analysis in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM11543((S)-3,5-Dihydroxyadamantylglycine-L-cis-4,5-methan...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as bufuralol 1'-hydroxylation preincubated for 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM11543((S)-3,5-Dihydroxyadamantylglycine-L-cis-4,5-methan...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as midazolam 1'-hydroxylation after 3 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM11543((S)-3,5-Dihydroxyadamantylglycine-L-cis-4,5-methan...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP2E1 in human liver microsomes assessed as chlorzoxazone 6-hydroxylation preincubated for 15 mins by LC-MS/MS analysis in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM11543((S)-3,5-Dihydroxyadamantylglycine-L-cis-4,5-methan...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as testosterone 6beta-hydroxylation after 3 mins by LC-MS/MS analysis in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM11543((S)-3,5-Dihydroxyadamantylglycine-L-cis-4,5-methan...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP1A2 in human liver microsomes assessed as phenacetin O-deethylation preincubated for 15 mins by LC-MS/MS analysis in presence of NAD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM11543((S)-3,5-Dihydroxyadamantylglycine-L-cis-4,5-methan...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP1A2 in human liver microsomes assessed as phenacetin O-deethylation after 3 mins by LC-MS/MS analysis in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM11543((S)-3,5-Dihydroxyadamantylglycine-L-cis-4,5-methan...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as midazolam 1'-hydroxylation preincubated for 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2A6(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM11543((S)-3,5-Dihydroxyadamantylglycine-L-cis-4,5-methan...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP2A6 in human liver microsomes assessed as coumarin 7-hydroxylation after 3 mins by LC-MS/MS analysis in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2A6(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM11543((S)-3,5-Dihydroxyadamantylglycine-L-cis-4,5-methan...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP2A6 in human liver microsomes assessed as coumarin 7-hydroxylation preincubated for 15 mins by LC-MS/MS analysis in presence of NADP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM11543((S)-3,5-Dihydroxyadamantylglycine-L-cis-4,5-methan...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP2B6 in human liver microsomes assessed as bupropion hydroxylation after 3 mins by LC-MS/MS analysis in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM11543((S)-3,5-Dihydroxyadamantylglycine-L-cis-4,5-methan...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP2B6 in human liver microsomes assessed as bupropion hydroxylation preincubated for 15 mins by LC-MS/MS analysis in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM11543((S)-3,5-Dihydroxyadamantylglycine-L-cis-4,5-methan...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as testosterone 6beta-hydroxylation preincubated for 15 mins by LC-MS/MS analysis in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM11543((S)-3,5-Dihydroxyadamantylglycine-L-cis-4,5-methan...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP2C8 in human liver microsomes assessed as paclitaxel 6alpha-hydroxylation after 3 mins by LC-MS/MS analysis in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM11543((S)-3,5-Dihydroxyadamantylglycine-L-cis-4,5-methan...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP2C8 in human liver microsomes assessed as paclitaxel 6alpha-hydroxylation preincubated for 15 mins by LC-MS/MS analysis in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM11543((S)-3,5-Dihydroxyadamantylglycine-L-cis-4,5-methan...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as paclitaxel 6alpha-hydroxylation after 3 mins by LC-MS/MS analysis in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM11543((S)-3,5-Dihydroxyadamantylglycine-L-cis-4,5-methan...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as paclitaxel 6alpha-hydroxylation preincubated for 15 mins by LC-MS/MS analysis in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed