Compile Data Set for Download or QSAR
Report error Found 38 Enz. Inhib. hit(s) with all data for entry = 50022579
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human PI3Kbeta using PIP2 as substrate preincubated for 20 mins followed by substrate and ATP addition and measured after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652937(CHEMBL5687044)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human PI3Kalpha using PIP2 as substrate preincubated for 20 mins followed by substrate and ATP addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652936(CHEMBL2133638)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant human PI3Kbeta using PIP2 as substrate preincubated for 20 mins followed by substrate and ATP addition and measured after 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 40nMAssay Description:Inhibition of PI3Kbeta in human MDA-MB-468 cells assessed as reduction in AKT phosphorylation at S473 residue measured after 2 hrs by Alexa Fluor 488...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 80nMAssay Description:Inhibition of recombinant human PI3Kdelta using PIP2 as substrate preincubated for 20 mins followed by substrate and ATP addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652937(CHEMBL5687044)
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant human PI3Kbeta using PIP2 as substrate preincubated for 20 mins followed by substrate and ATP addition and measured after 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 120nMAssay Description:Inhibition of PI3Kbeta in human blood assessed as reduction in whole blood shear-induced platelet adhesion and aggregation by measuring reduction in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50389046(CHEMBL2064327)
Affinity DataIC50: 160nMAssay Description:Inhibition of recombinant human PI3Kbeta using PIP2 as substrate preincubated for 20 mins followed by substrate and ATP addition and measured after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 210nMAssay Description:Inhibition of PI3Kbeta in human blood assessed as reduction in collagen-induced platelet aggregation preincubated for 5 mins followed by collagen add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 270nMAssay Description:Inhibition of PI3Kbeta in human blood assessed as reduction in ADP-induced platelet aggregation preincubated for 5 mins followed by ADP addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 420nMAssay Description:Inhibition of human DNA-PK assessed as reduction in protein phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 620nMAssay Description:Inhibition of PI3Kbeta in human platelet rich plasma assessed as reduction in ADP-induced platelet aggregation preincubated for 10 mins followed by 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 870nMAssay Description:Inhibition of recombinant human PI3Kalpha using PIP2 as substrate preincubated for 20 mins followed by substrate and ATP addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 1.09E+3nMAssay Description:Inhibition of recombinant human PI3Kgamma using PIP2 as substrate preincubated for 20 mins followed by substrate and ATP addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50652936(CHEMBL2133638)
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of recombinant human PI3Kalpha using PIP2 as substrate preincubated for 20 mins followed by substrate and ATP addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of PI3Kbeta in rat blood assessed as reduction in ADP-induced platelet aggregation preincubated for 5 mins followed by ADP addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50204104(CHEMBL3979323)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of recombinant human PI3Kbeta using PIP2 as substrate preincubated for 20 mins followed by substrate and ATP addition and measured after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 2.93E+3nMAssay Description:Inhibition of PI3Kbeta in human platelet rich plasma assessed as reduction in ADP-induced platelet aggregation preincubated for 10 mins followed by 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of PI3Kbeta in human adipocytes assessed as reduction in insulin-induced 2-deoxy-[U-14C]-glucose uptake preincubated for 3 hrs followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of phosphodiesterase 4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50389046(CHEMBL2064327)
Affinity DataIC50: 2.28E+4nMAssay Description:Inhibition of recombinant human PI3Kalpha using PIP2 as substrate preincubated for 20 mins followed by substrate and ATP addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase B(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of human AurKBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine-protein kinase ATM(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of ATM (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 3.70E+4nMAssay Description:Inhibition of human srcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 8.40E+4nMAssay Description:Inhibition of human PLKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase CSK(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 9.00E+4nMAssay Description:Inhibition of human CSKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 1.17E+5nMAssay Description:Inhibition of human KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 2.01E+5nMAssay Description:Inhibition of human JAK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 2.58E+5nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 2.98E+5nMAssay Description:Inhibition of human EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 3.36E+5nMAssay Description:Inhibition of human PAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 6.71E+5nMAssay Description:Inhibition of human p38aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 6.99E+5nMAssay Description:Inhibition of human FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 9.99E+5nMAssay Description:Inhibition of human ZAP70More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human CHK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFocal adhesion kinase 1(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human FAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human CDK2/Cyclin EMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed