Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 50005282
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490579BDBM50490579(CHEMBL2337154)
Affinity DataIC50: 0.402nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490580BDBM50490580(CHEMBL2337153)
Affinity DataIC50: 0.555nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490579BDBM50490579(CHEMBL2337154)
Affinity DataIC50: 0.830nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta42 secretion by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490580BDBM50490580(CHEMBL2337153)
Affinity DataIC50: 0.880nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta42 secretion by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490588BDBM50490588(CHEMBL2336728)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490580BDBM50490580(CHEMBL2337153)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of notch intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490588BDBM50490588(CHEMBL2336728)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta42 secretion by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490578BDBM50490578(CHEMBL2337566)
Affinity DataIC50: 8.80nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490578BDBM50490578(CHEMBL2337566)
Affinity DataIC50: 9.90nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta42 secretion by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490578BDBM50490578(CHEMBL2337566)
Affinity DataIC50: 20nMAssay Description:Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of notch intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490579BDBM50490579(CHEMBL2337154)
Affinity DataIC50: 41nMAssay Description:Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of notch intracel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490580BDBM50490580(CHEMBL2337153)
Affinity DataIC50: 68nMAssay Description:Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of Abeta42 secret...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490579BDBM50490579(CHEMBL2337154)
Affinity DataIC50: 84nMAssay Description:Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of IAbeta40 secre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490580BDBM50490580(CHEMBL2337153)
Affinity DataIC50: 85nMAssay Description:Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of IAbeta40 secre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490579BDBM50490579(CHEMBL2337154)
Affinity DataIC50: 86nMAssay Description:Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of Abeta42 secret...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 28922BDBM28922((2S)-N-(5-chlorothiophen-2-yl)-4,4,4-trifluoro-1-h...)
Affinity DataIC50: 203nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490586BDBM50490586(CHEMBL2337559)
Affinity DataIC50: 225nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta42 secretion by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490586BDBM50490586(CHEMBL2337559)
Affinity DataIC50: 244nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 28922BDBM28922((2S)-N-(5-chlorothiophen-2-yl)-4,4,4-trifluoro-1-h...)
Affinity DataIC50: 414nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta42 secretion by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490578BDBM50490578(CHEMBL2337566)
Affinity DataIC50: 626nMAssay Description:Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of Abeta42 secret...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490578BDBM50490578(CHEMBL2337566)
Affinity DataIC50: 1.18E+3nMAssay Description:Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of IAbeta40 secre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490581BDBM50490581(CHEMBL2337560)
Affinity DataIC50: 2.28E+3nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490581BDBM50490581(CHEMBL2337560)
Affinity DataIC50: 5.21E+3nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta42 secretion by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490585BDBM50490585(CHEMBL602560)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta42 secretion by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490584BDBM50490584(CHEMBL2337565)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta42 secretion by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490589BDBM50490589(CHEMBL2337563)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta42 secretion by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490583BDBM50490583(CHEMBL2337562)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta42 secretion by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490589BDBM50490589(CHEMBL2337563)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490582BDBM50490582(CHEMBL2337561)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta42 secretion by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490587BDBM50490587(CHEMBL2337564)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta42 secretion by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490582BDBM50490582(CHEMBL2337561)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490583BDBM50490583(CHEMBL2337562)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490587BDBM50490587(CHEMBL2337564)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490584BDBM50490584(CHEMBL2337565)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50490585BDBM50490585(CHEMBL602560)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed