Compile Data Set for Download or QSAR
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Found 8 Enz. Inhib. hit(s) with all data for entry = 50033060
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50296742(1,4-diazabicyclo[3.2.2]nonane-(4-bromo)-phenyl car...)
Affinity DataKi:  14nMAssay Description:Binding affinity to human alpha7 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50339001((S)-4-bromophenyl hexahydro-1H-pyrrolo[1,2-a][1,4]...)
Affinity DataIC50:  5.60E+3nMAssay Description:Competitive antagonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-induced current by voltage clamp meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50339002(((3S,9aR)-hexahydro-3-methyl-1H-pyrido[1,2-a]pyraz...)
Affinity DataIC50:  6.10E+3nMAssay Description:Non competitive antagonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-induced current by voltage clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50339003((4-chlorophenyl)(4-isopropyl-1,4-diazocan-1-yl)met...)
Affinity DataIC50:  7.00E+3nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-induced current by voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50339004(4-chloro-N-((hexahydro-1H-pyrrolizin-7a-yl)methyl)...)
Affinity DataIC50:  7.20E+3nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-induced current by voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Affinity DataEC50:  6.90E+4nMAssay Description:Agonist activity at human recombinant alpha7 nAChR expressed in Xenopus oocyte in presence of 6 uM (S)-ethyl 1-(2-cyanoethyl)pyrrolidine-2-carboxylat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Affinity DataEC50:  8.70E+4nMAssay Description:Agonist activity at human recombinant alpha7 nAChR expressed in Xenopus oocyteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50296742(1,4-diazabicyclo[3.2.2]nonane-(4-bromo)-phenyl car...)
Affinity DataEC50:  4.40E+3nMAssay Description:Partial agonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as evoked ACh-induced current by voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed