Compile Data Set for Download or QSAR
Report error Found 68 Enz. Inhib. hit(s) with all data for entry = 50045316
LigandChemical structure of BindingDB Monomer ID 50056351BDBM50056351(CHEMBL3326569)
Affinity DataIC50: 2nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50056358BDBM50056358(CHEMBL3326581)
Affinity DataIC50: 3nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50056434BDBM50056434(CHEMBL3326575)
Affinity DataIC50: 4nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50232114BDBM50232114(N-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-N'...)
Affinity DataIC50: 4nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50056352BDBM50056352(CHEMBL3326570)
Affinity DataIC50: 4nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50056387BDBM50056387(CHEMBL3326582)
Affinity DataIC50: 5nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50056389BDBM50056389(CHEMBL3326584)
Affinity DataIC50: 5nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50056408BDBM50056408(CHEMBL3326587)
Affinity DataIC50: 5nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50056426BDBM50056426(CHEMBL3326589)
Affinity DataIC50: 5nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50056353BDBM50056353(CHEMBL3326576)
Affinity DataIC50: 6nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50056354BDBM50056354(CHEMBL3326577)
Affinity DataIC50: 6nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50056437BDBM50056437(CHEMBL3326572)
Affinity DataIC50: 7nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50056436BDBM50056436(CHEMBL3326573)
Affinity DataIC50: 7nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50056435BDBM50056435(CHEMBL3326574)
Affinity DataIC50: 7nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50056425BDBM50056425(CHEMBL3326588)
Affinity DataIC50: 9nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50056386BDBM50056386(CHEMBL3325460)
Affinity DataIC50: 10nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50321851BDBM50321851(CHEMBL1173240 | US8796328, D | (R)-8-{5-[3-Methyl-...)
Affinity DataIC50: 12nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50056438BDBM50056438(CHEMBL3326571)
Affinity DataIC50: 16nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50056391BDBM50056391(CHEMBL3326586)
Affinity DataIC50: 17nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50056439BDBM50056439(CHEMBL3326568)
Affinity DataIC50: 21nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50056427BDBM50056427(CHEMBL3326909)
Affinity DataIC50: 22nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50056429BDBM50056429(CHEMBL3326914)
Affinity DataIC50: 22nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50056388BDBM50056388(CHEMBL3326583)
Affinity DataIC50: 32nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50056390BDBM50056390(CHEMBL3326585)
Affinity DataIC50: 32nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50056356BDBM50056356(CHEMBL3326579)
Affinity DataIC50: 34nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50056428BDBM50056428(CHEMBL3326915)
Affinity DataIC50: 36nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50056355BDBM50056355(CHEMBL3326578)
Affinity DataIC50: 40nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50056431BDBM50056431(CHEMBL3326912)
Affinity DataIC50: 60nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50056433BDBM50056433(CHEMBL3326910)
Affinity DataIC50: 74nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Abbvie

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50056353BDBM50056353(CHEMBL3326576)
Affinity DataIC50: 80nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using AMMC substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Abbvie

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50056352BDBM50056352(CHEMBL3326570)
Affinity DataIC50: 80nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using AMMC substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Abbvie

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50056351BDBM50056351(CHEMBL3326569)
Affinity DataIC50: 80nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using AMMC substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Abbvie

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50056354BDBM50056354(CHEMBL3326577)
Affinity DataIC50: 80nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using AMMC substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50056432BDBM50056432(CHEMBL3326911)
Affinity DataIC50: 97nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50056357BDBM50056357(CHEMBL3326580)
Affinity DataIC50: 150nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50056430BDBM50056430(CHEMBL3326913)
Affinity DataIC50: 350nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Abbvie

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50056352BDBM50056352(CHEMBL3326570)
Affinity DataIC50: 660nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using 7-benzyloxyquiniline substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Abbvie

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50056351BDBM50056351(CHEMBL3326569)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using 7-benzyloxyquiniline substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Abbvie

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50056353BDBM50056353(CHEMBL3326576)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using 7-benzyloxyquiniline substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Abbvie

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50056354BDBM50056354(CHEMBL3326577)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using 7-benzyloxyquiniline substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Abbvie

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50056425BDBM50056425(CHEMBL3326588)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using AMMC substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Abbvie

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50056390BDBM50056390(CHEMBL3326585)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using AMMC substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Abbvie

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50056427BDBM50056427(CHEMBL3326909)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using AMMC substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Abbvie

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50056391BDBM50056391(CHEMBL3326586)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using 7-benzyloxyquiniline substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Abbvie

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50056358BDBM50056358(CHEMBL3326581)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using AMMC substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Abbvie

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50056389BDBM50056389(CHEMBL3326584)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using 7-benzyloxyquiniline substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Abbvie

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50056408BDBM50056408(CHEMBL3326587)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using AMMC substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Abbvie

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50056391BDBM50056391(CHEMBL3326586)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using AMMC substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Abbvie

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50056427BDBM50056427(CHEMBL3326909)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using 7-benzyloxyquiniline substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Abbvie

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50056426BDBM50056426(CHEMBL3326589)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using 7-benzyloxyquiniline substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
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