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Found 27 Enz. Inhib. hit(s) with all data for entry = 6836
TargetPhosphodiesterase(Trypanosoma brucei)
Northeastern University

LigandPNGBDBM153391(3-(3-carbamoyl-4-(3-methoxyphenylamino)-8-methylqu...)
Affinity DataIC50:  2.90E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Northeastern University

LigandPNGBDBM153402(4-((3-Methoxyphenyl)amino)-8-methyl-6-(1-methyl-1H...)
Affinity DataIC50:  3.10E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Northeastern University

LigandPNGBDBM153390(Methyl 3-(3-carbamoyl-4-(3-methoxyphenylamino)-8-m...)
Affinity DataIC50:  3.50E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Northeastern University

LigandPNGBDBM153408(8-Methyl-6-(1-methyl-1H-indazol-6-yl)-4-(m-tolylam...)
Affinity DataIC50:  3.50E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Northeastern University

LigandPNGBDBM153407(4-(3-Ethylphenylamino)-8-methyl-6-(1-methyl-1H-ind...)
Affinity DataIC50:  3.50E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Northeastern University

LigandPNGBDBM153412(8-Ethyl-4-((3-methoxyphenyl)amino)-6-(1-methyl-1H-...)
Affinity DataIC50:  3.70E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Northeastern University

LigandPNGBDBM153409(4-(4-Methoxy-3-methylphenylamino)-8-methyl-6-(1-me...)
Affinity DataIC50:  3.70E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Northeastern University

LigandPNGBDBM153406(4-((3-Ethoxyphenyl)amino)-8-methyl-6-(1-methyl-1H-...)
Affinity DataIC50:  4.20E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Northeastern University

LigandPNGBDBM153410(4-(Cyclopentylamino)-8-methyl-6-(3-(oxazol-2-yl)ph...)
Affinity DataIC50:  5.90E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Northeastern University

LigandPNGBDBM153401(6-(1H-Indol-5-yl)-4-((3-methoxyphenyl)amino)-8-met...)
Affinity DataIC50:  5.90E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Northeastern University

LigandPNGBDBM153399(4-((3-Methoxyphenyl)amino)-8-methyl-6-(3-(oxazol-2...)
Affinity DataIC50:  5.90E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Northeastern University

LigandPNGBDBM153398(4-((3-Methoxyphenyl)amino)-8-methyl-6-(3-(5-methyl...)
Affinity DataIC50:  6.00E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Northeastern University

LigandPNGBDBM153394(Methyl 3-(3-carbamoyl-4-((3-methoxyphenyl)amino)-8...)
Affinity DataIC50:  6.40E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Northeastern University

LigandPNGBDBM153397(6-(3-(1H-Tetrazol-5-yl)phenyl)-4-((3-methoxyphenyl...)
Affinity DataIC50:  6.70E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Northeastern University

LigandPNGBDBM153405(4-((2-Methoxyphenyl)amino)-8-methyl-6-(1-methyl-1H...)
Affinity DataIC50:  7.00E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Northeastern University

LigandPNGBDBM50415001(CHEMBL570015 | GSK-256066 | GSK-256066 (3))
Affinity DataIC50:  7.90E+3nMAssay Description:This assay was performed at Takeda Pharmaceuticals using methods previously reported.More data for this Ligand-Target Pair
TargetPhosphodiesterase(Trypanosoma brucei)
Northeastern University

LigandPNGBDBM153396(4-((3-Methoxyphenyl)amino)-8-methyl-6-(1H-pyrazol-...)
Affinity DataIC50:  9.00E+3nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Northeastern University

LigandPNGBDBM153400(4-((3-Methoxyphenyl)amino)-8-methyl-6-(3-morpholin...)
Affinity DataIC50:  1.20E+4nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Northeastern University

LigandPNGBDBM153411(4-((3-Methoxyphenyl)amino)-6-(1-methyl-1H-indazol-...)
Affinity DataIC50:  1.20E+4nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Northeastern University

LigandPNGBDBM153393(Methyl 3-(3-carbamoyl-4-(3-methoxyphenylamino)-8-m...)
Affinity DataIC50:  1.60E+4nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Northeastern University

LigandPNGBDBM153395(6-(3-Aminophenyl)-4-((3-methoxyphenyl)amino)-8-met...)
Affinity DataIC50:  2.30E+4nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Northeastern University

LigandPNGBDBM50415001(CHEMBL570015 | GSK-256066 | GSK-256066 (3))
Affinity DataIC50:  2.40E+4nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Northeastern University

LigandPNGBDBM153404(Methyl 3-(3-carbamoyl-8-methyl-4-(pyridin-3-ylamin...)
Affinity DataIC50:  2.60E+4nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Northeastern University

LigandPNGBDBM153403(Methyl 3-(4-(benzylamino)-3-carbamoyl-8-methylquin...)
Affinity DataIC50:  2.80E+4nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Trypanosoma brucei)
Northeastern University

LigandPNGBDBM153392(4-(3-methoxyphenylamino)-8-methyl-6-(3-(methylcarb...)
Affinity DataIC50:  3.10E+4nMpH: 7.4Assay Description:In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Northeastern University

LigandPNGBDBM153394(Methyl 3-(3-carbamoyl-4-((3-methoxyphenyl)amino)-8...)
Affinity DataIC50:  4.20E+4nMAssay Description:This assay was performed at Takeda Pharmaceuticals using methods previously reported.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Northeastern University

LigandPNGBDBM153402(4-((3-Methoxyphenyl)amino)-8-methyl-6-(1-methyl-1H...)
Affinity DataIC50:  8.30E+4nMAssay Description:This assay was performed at Takeda Pharmaceuticals using methods previously reported.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed