Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) with all data for entry = 50045602
TargetFatty acid synthase(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataKi:  3.40E+3nMAssay Description:Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50241342(CHEMBL1502 | Protonix | SK-96022 | 6-(difluorometh...)
Affinity DataKi:  4.10E+3nMAssay Description:Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50070208(CHEBI:6375 | A-65006 | AG-1749 | Lansoprazole | Pr...)
Affinity DataKi:  5.30E+3nMAssay Description:Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50070209(CHEBI:8768 | Aciphex | LY-307640 | Rabeprazole)
Affinity DataKi:  5.90E+3nMAssay Description:Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataIC50: 2.96E+4nMAssay Description:Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50241342(CHEMBL1502 | Protonix | SK-96022 | 6-(difluorometh...)
Affinity DataIC50: 3.62E+4nMAssay Description:Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50070208(CHEBI:6375 | A-65006 | AG-1749 | Lansoprazole | Pr...)
Affinity DataIC50: 4.67E+4nMAssay Description:Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50070209(CHEBI:8768 | Aciphex | LY-307640 | Rabeprazole)
Affinity DataIC50: 5.20E+4nMAssay Description:Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50070208(CHEBI:6375 | A-65006 | AG-1749 | Lansoprazole | Pr...)
Affinity DataIC50: 9.30E+4nMAssay Description:Inhibition of FASN in human PANC1 cells assessed as inhibition of [14C]acetate incorporation preincubated for 4 hrs before [14C]acetate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50070208(CHEBI:6375 | A-65006 | AG-1749 | Lansoprazole | Pr...)
Affinity DataIC50: 1.24E+5nMAssay Description:Inhibition of FASN in human BxPC3 cells assessed as inhibition of [14C]acetate incorporation preincubated for 4 hrs before [14C]acetate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM24567(Tetrahydrolipstatin | CHEMBL175247 | Xenical | (2S...)
Affinity DataIC50: 2.03E+5nMAssay Description:Inhibition of FASN in human PANC1 cells assessed as inhibition of [14C]acetate incorporation preincubated for 4 hrs before [14C]acetate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed