Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) with all data for entry = 50022523
LigandPNGBDBM50060417(CHEMBL297784 | SB 206553 | SB-206553 | 5-Methyl-3,...)
Affinity DataKi:  19nMAssay Description:Inhibition of [3H]LSD binding to 5-HT2B receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50247349(CHEMBL4072005)
Affinity DataIC50: 31nMAssay Description:Inhibition of PRMT3 (unknown origin) using C-terminal biotinylated histone H4 (1 to 24 residues) as substrate and SAM as cofactor in presence of [3H]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50247349(CHEMBL4072005)
Affinity DataKd:  53nMAssay Description:Binding affinity to PRMT3 (unknown origin) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50247349(CHEMBL4072005)
Affinity DataIC50: 66nMAssay Description:Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 21 residues) as substrate and SAM as cofactor preincubated for 20 mins followed by substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50247349(CHEMBL4072005)
Affinity DataKd:  85nMAssay Description:Binding affinity to biotinylated PRMT3 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50247349(CHEMBL4072005)
Affinity DataIC50: 91nMAssay Description:Inhibition of wild type Flag-tagged human PRMT3 catalytic activity transfected in HEK293 cells assessed as inhibition of exogenous GFP-tagged H4R3 as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50247349(CHEMBL4072005)
Affinity DataIC50: 225nMAssay Description:Inhibition of wild type Flag-tagged human PRMT3 catalytic activity transfected in HEK293 cells assessed as reduction in H4R3me2a level incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50247349(CHEMBL4072005)
Affinity DataEC50:  1.30E+3nMAssay Description:Binding affinity to ePL-tagged human PRMT3 methyltransferase domain (211 to 531 residues) expressed in HEK293 cells assessed as protein stabilization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50247349(CHEMBL4072005)
Affinity DataEC50:  1.60E+3nMAssay Description:Binding affinity to ePL-tagged human PRMT3 methyltransferase domain (211 to 531 residues) expressed in human A549 cells assessed as protein stabiliza...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50427768(CHEMBL2325441)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of PRMT3 (unknown origin) using C-terminal biotinylated histone H4 (1 to 24 residues) as substrate and SAM as cofactor in presence of [3H]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50247349(CHEMBL4072005)
Affinity DataKi: >1.50E+4nMAssay Description:Inhibition of [3H]LSD binding to 5-HT2B receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed