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Found 84 Enz. Inhib. hit(s) with all data for entry = 50035783
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017536((Flumezapine)7-Fluoro-2-methyl-10-(4-methyl-pipera...)
Affinity DataIC50:  20nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor D2 from rat brain striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50017536((Flumezapine)7-Fluoro-2-methyl-10-(4-methyl-pipera...)
Affinity DataIC50:  80nMAssay Description:50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation at 3 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017646(7-Chloro-2-cyclopentyl-10-(4-methyl-piperazin-1-yl...)
Affinity DataIC50:  140nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor D2 from rat brain striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataIC50:  180nMAssay Description:The equilibrium dissociation constant of the inhibitor-enzyme complex of human carbonic anhydraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017634(7-Fluoro-10-(4-methyl-piperazin-1-yl)-2-propyl-2,4...)
Affinity DataIC50:  180nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataIC50:  250nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017615(7-Chloro-2-ethyl-10-(4-methyl-piperazin-1-yl)-2,4-...)
Affinity DataIC50:  340nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor D2 from rat brain striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017631(2-Benzyl-7-fluoro-10-(4-methyl-piperazin-1-yl)-2,4...)
Affinity DataIC50:  400nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor D2 from rat brain striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017630(7-Chloro-2-methyl-10-(4-methyl-piperazin-1-yl)-2,4...)
Affinity DataIC50:  680nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor D2 from rat brain striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017628(7-Bromo-2-methyl-10-(4-methyl-piperazin-1-yl)-2,4-...)
Affinity DataIC50:  680nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017626(7-Fluoro-2-hexyl-10-(4-methyl-piperazin-1-yl)-2,4-...)
Affinity DataIC50:  700nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor D2 from rat brain striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017617(6,7-Difluoro-2-methyl-10-(4-methyl-piperazin-1-yl)...)
Affinity DataIC50:  760nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor D2 from rat brain striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017644(8-Chloro-2-methyl-10-(4-methyl-piperazin-1-yl)-2,4...)
Affinity DataIC50:  860nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017633(10-(4-Cyclopropylmethyl-piperazin-1-yl)-7-fluoro-2...)
Affinity DataIC50:  900nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50017622(6,7-Dichloro-2-ethyl-10-(4-methyl-piperazin-1-yl)-...)
Affinity DataIC50: >1.00E+3nMAssay Description:50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation at 3 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50017615(7-Chloro-2-ethyl-10-(4-methyl-piperazin-1-yl)-2,4-...)
Affinity DataIC50: >1.00E+3nMAssay Description:50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation for 4 min at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50017624(7-Fluoro-2-methyl-10-(4-methyl-4-oxy-piperazin-1-y...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of [3H]QNB binding to muscarinic cholinergic receptor from male Olac rat brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50017645(6,7-Dichloro-2-methyl-10-(4-methyl-piperazin-1-yl)...)
Affinity DataIC50: >1.00E+3nMAssay Description:50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation at 3 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50017625(CHEMBL262164 | [2-Methyl-10-(4-methyl-piperazin-1-...)
Affinity DataIC50: >1.00E+3nMAssay Description:50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation for 4 min at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017653(7-Iodo-2-methyl-10-(4-methyl-piperazin-1-yl)-2,4-d...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017635(7-Fluoro-2-isopropyl-10-(4-methyl-piperazin-1-yl)-...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017613(2-Methyl-10-(4-methyl-piperazin-1-yl)-7-trifluorom...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017627(7-Fluoro-2-methyl-10-(4-methyl-piperazin-1-yl)-1-p...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor D2 from rat brain striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017638(7-Chloro-2-decyl-10-(4-methyl-piperazin-1-yl)-2,4-...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017650(7-Fluoro-10-(4-methyl-piperazin-1-yl)-2-phenyl-2,4...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017641(6-Fluoro-2-methyl-10-(4-methyl-piperazin-1-yl)-2,4...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor D2 from rat brain striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017636(7-Fluoro-2-methyl-10-(4-methyl-piperazin-1-yl)-2,4...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor D2 from rat brain striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017651(10-(4-Benzyl-piperazin-1-yl)-7-fluoro-2-methyl-2,4...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50017619(7-Fluoro-1,2-dimethyl-10-(4-methyl-piperazin-1-yl)...)
Affinity DataIC50:  3.20E+3nMAssay Description:50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation for 4 min at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017648(2-Ethyl-7-fluoro-10-(4-methyl-piperazin-1-yl)-2,4-...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor D2 from rat brain striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017637(7-Chloro-2-isobutyl-10-(4-methyl-piperazin-1-yl)-2...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor D2 from rat brain striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017622(6,7-Dichloro-2-ethyl-10-(4-methyl-piperazin-1-yl)-...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017647(5-Chloro-2-methyl-10-(4-methyl-piperazin-1-yl)-2,4...)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017623(2-[4-(7-Fluoro-2-methyl-2,4-dihydro-2,3,4,9-tetraa...)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017640(7-Fluoro-2-methyl-10-piperazin-1-yl-2,4-dihydro-2,...)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017643(2,6-Dimethyl-10-(4-methyl-piperazin-1-yl)-2,4-dihy...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50017620(CHEMBL86342 | N'-(7-Fluoro-2-methyl-2,4-dihydro-2,...)
Affinity DataIC50:  6.10E+3nMAssay Description:50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation for 4 min at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017618(2-Methyl-10-(4-methyl-piperazin-1-yl)-2,4-dihydro-...)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50017635(7-Fluoro-2-isopropyl-10-(4-methyl-piperazin-1-yl)-...)
Affinity DataIC50:  7.20E+3nMAssay Description:Compound was evaluated for the inhibition of [3H]QNB binding to Muscarinic acetylcholine receptor from male Olac rat brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50017630(7-Chloro-2-methyl-10-(4-methyl-piperazin-1-yl)-2,4...)
Affinity DataIC50:  8.90E+3nMAssay Description:Inhibition of [3H]QNB binding to muscarinic cholinergic receptor from male Olac rat brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017621(7-Fluoro-1,3-dimethyl-10-(4-methyl-piperazin-1-yl)...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017624(7-Fluoro-2-methyl-10-(4-methyl-4-oxy-piperazin-1-y...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor D2 from rat brain striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017614(7-Chloro-2-methyl-2,4-dihydro-2,3,4,9-tetraaza-ben...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017645(6,7-Dichloro-2-methyl-10-(4-methyl-piperazin-1-yl)...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017632(4-(7-Fluoro-2-methyl-2,4-dihydro-2,3,4,9-tetraaza-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017649(7-Fluoro-2,3-dimethyl-10-(4-methyl-piperazin-1-yl)...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017639(7-Fluoro-2-methyl-10-piperidin-1-yl-2,4-dihydro-2,...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017652(7-Methanesulfonyl-2-methyl-10-(4-methyl-piperazin-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017629(6-Chloro-2-methyl-10-(4-methyl-piperazin-1-yl)-2,4...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50017625(CHEMBL262164 | [2-Methyl-10-(4-methyl-piperazin-1-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from striatum of the rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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