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Found 79 Enz. Inhib. hit(s) with all data for entry = 50045789
TargetCytochrome P450 1A2(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081468(CHEMBL3422028)
Affinity DataKi:  56nMAssay Description:Inhibition of human recombinant CYP1A2 assessed as metabolism of 3-cyano-7-ethoxycoumarin after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50435005(CHEMBL2386285)
Affinity DataKi:  76nMAssay Description:Inhibition of human recombinant CYP1A2 assessed as metabolism of 3-cyano-7-ethoxycoumarin after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50435005(CHEMBL2386285)
Affinity DataKi:  375nMAssay Description:Inhibition of human recombinant CYP3A4 assessed as metabolism of 7-benzyloxy-4-trifluoromethylcoumarin to HFC after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081468(CHEMBL3422028)
Affinity DataKi:  423nMAssay Description:Inhibition of human recombinant CYP2D6 after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081468(CHEMBL3422028)
Affinity DataKi:  710nMAssay Description:Inhibition of human recombinant CYP2A6 assessed as metabolism of coumarin to 7-hydroxycoumarin after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A5(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50435005(CHEMBL2386285)
Affinity DataKi:  829nMAssay Description:Inhibition of human recombinant CYP3A5 assessed as metabolism of 7-benzyloxy-4-trifluoromethylcoumarin to HFC after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A5(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081468(CHEMBL3422028)
Affinity DataKi:  855nMAssay Description:Inhibition of human recombinant CYP3A5 assessed as metabolism of 7-benzyloxy-4-trifluoromethylcoumarin to HFC after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081468(CHEMBL3422028)
Affinity DataKi:  1.64E+3nMAssay Description:Inhibition of human recombinant CYP3A4 assessed as metabolism of 7-benzyloxy-4-trifluoromethylcoumarin to HFC after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50435005(CHEMBL2386285)
Affinity DataKi:  2.18E+3nMAssay Description:Inhibition of human recombinant CYP2A6 assessed as metabolism of coumarin to 7-hydroxycoumarin after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM13061(4,4 -(1H-1,2,4-triazol-1-ylmethanediyl)dibenzonitr...)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of human recombinant aromatase using 7-methoxy-trifluoromethylcoumarin as substrate assessed as formation of fluorescent metabolite after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAromatase(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081410(CHEMBL3422041)
Affinity DataIC50:  17nMAssay Description:Inhibition of human recombinant aromatase using 7-methoxy-trifluoromethylcoumarin as substrate assessed as formation of fluorescent metabolite after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081468(CHEMBL3422028)
Affinity DataIC50:  45nMAssay Description:Inhibition of human recombinant aromatase using 7-methoxy-trifluoromethylcoumarin as substrate assessed as formation of fluorescent metabolite after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081463(CHEMBL3422033)
Affinity DataIC50:  48nMAssay Description:Inhibition of human recombinant aromatase using 7-methoxy-trifluoromethylcoumarin as substrate assessed as formation of fluorescent metabolite after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081416(CHEMBL3422040)
Affinity DataIC50:  49nMAssay Description:Inhibition of human recombinant aromatase using 7-methoxy-trifluoromethylcoumarin as substrate assessed as formation of fluorescent metabolite after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081464(CHEMBL3422032)
Affinity DataIC50:  53nMAssay Description:Inhibition of human recombinant aromatase using 7-methoxy-trifluoromethylcoumarin as substrate assessed as formation of fluorescent metabolite after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50435005(CHEMBL2386285)
Affinity DataIC50:  102nMAssay Description:Inhibition of human recombinant aromatase using 7-methoxy-trifluoromethylcoumarin as substrate assessed as formation of fluorescent metabolite after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081432(CHEMBL3422036)
Affinity DataIC50:  143nMAssay Description:Inhibition of human recombinant aromatase using 7-methoxy-trifluoromethylcoumarin as substrate assessed as formation of fluorescent metabolite after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081408(CHEMBL3422042)
Affinity DataIC50:  174nMAssay Description:Inhibition of human recombinant aromatase using 7-methoxy-trifluoromethylcoumarin as substrate assessed as formation of fluorescent metabolite after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081468(CHEMBL3422028)
Affinity DataIC50:  207nMAssay Description:Inhibition of human recombinant CYP1A2 assessed as metabolism of 3-cyano-7-ethoxycoumarin after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50435005(CHEMBL2386285)
Affinity DataIC50:  207nMAssay Description:Inhibition of human recombinant CYP1A2 assessed as metabolism of 3-cyano-7-ethoxycoumarin after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081430(CHEMBL3422037)
Affinity DataIC50:  261nMAssay Description:Inhibition of human recombinant aromatase using 7-methoxy-trifluoromethylcoumarin as substrate assessed as formation of fluorescent metabolite after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50435005(CHEMBL2386285)
Affinity DataIC50:  285nMAssay Description:Inhibition of human recombinant CYP3A4 assessed as metabolism of 7-benzyloxy-4-trifluoromethylcoumarin to HFC after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081421(CHEMBL3422038)
Affinity DataIC50:  328nMAssay Description:Inhibition of human recombinant aromatase using 7-methoxy-trifluoromethylcoumarin as substrate assessed as formation of fluorescent metabolite after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081433(CHEMBL3422035)
Affinity DataIC50:  337nMAssay Description:Inhibition of human recombinant aromatase using 7-methoxy-trifluoromethylcoumarin as substrate assessed as formation of fluorescent metabolite after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081536(CHEMBL3422052)
Affinity DataIC50:  491nMAssay Description:Inhibition of human recombinant aromatase using 7-methoxy-trifluoromethylcoumarin as substrate assessed as formation of fluorescent metabolite after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081469(CHEMBL3422045)
Affinity DataIC50:  493nMAssay Description:Inhibition of human recombinant aromatase using 7-methoxy-trifluoromethylcoumarin as substrate assessed as formation of fluorescent metabolite after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A5(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081468(CHEMBL3422028)
Affinity DataIC50:  556nMAssay Description:Inhibition of human recombinant CYP3A5 assessed as metabolism of 7-benzyloxy-4-trifluoromethylcoumarin to HFC after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081403(CHEMBL3422044)
Affinity DataIC50:  699nMAssay Description:Inhibition of human recombinant aromatase using 7-methoxy-trifluoromethylcoumarin as substrate assessed as formation of fluorescent metabolite after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081407(CHEMBL3422043)
Affinity DataIC50:  715nMAssay Description:Inhibition of human recombinant aromatase using 7-methoxy-trifluoromethylcoumarin as substrate assessed as formation of fluorescent metabolite after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A5(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50435005(CHEMBL2386285)
Affinity DataIC50:  723nMAssay Description:Inhibition of human recombinant CYP3A5 assessed as metabolism of 7-benzyloxy-4-trifluoromethylcoumarin to HFC after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081465(CHEMBL3422031)
Affinity DataIC50:  913nMAssay Description:Inhibition of human recombinant aromatase using 7-methoxy-trifluoromethylcoumarin as substrate assessed as formation of fluorescent metabolite after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081467(CHEMBL3422029)
Affinity DataIC50:  1.02E+3nMAssay Description:Inhibition of human recombinant aromatase using 7-methoxy-trifluoromethylcoumarin as substrate assessed as formation of fluorescent metabolite after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081530(CHEMBL3422050)
Affinity DataIC50:  1.24E+3nMAssay Description:Inhibition of human recombinant aromatase using 7-methoxy-trifluoromethylcoumarin as substrate assessed as formation of fluorescent metabolite after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081466(CHEMBL3422030)
Affinity DataIC50:  1.32E+3nMAssay Description:Inhibition of human recombinant aromatase using 7-methoxy-trifluoromethylcoumarin as substrate assessed as formation of fluorescent metabolite after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081468(CHEMBL3422028)
Affinity DataIC50:  1.88E+3nMAssay Description:Inhibition of human recombinant CYP3A4 assessed as metabolism of 7-benzyloxy-4-trifluoromethylcoumarin to HFC after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081418(CHEMBL3422039)
Affinity DataIC50:  1.93E+3nMAssay Description:Inhibition of human recombinant aromatase using 7-methoxy-trifluoromethylcoumarin as substrate assessed as formation of fluorescent metabolite after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081468(CHEMBL3422028)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of human recombinant CYP2D6 after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081471(CHEMBL3422047)
Affinity DataIC50:  3.68E+3nMAssay Description:Inhibition of human recombinant aromatase using 7-methoxy-trifluoromethylcoumarin as substrate assessed as formation of fluorescent metabolite after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081462(CHEMBL3422034)
Affinity DataIC50:  6.29E+3nMAssay Description:Inhibition of human recombinant aromatase using 7-methoxy-trifluoromethylcoumarin as substrate assessed as formation of fluorescent metabolite after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50435005(CHEMBL2386285)
Affinity DataIC50:  6.37E+3nMAssay Description:Inhibition of human recombinant CYP2A6 assessed as metabolism of coumarin to 7-hydroxycoumarin after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081468(CHEMBL3422028)
Affinity DataIC50:  6.37E+3nMAssay Description:Inhibition of human recombinant CYP2A6 assessed as metabolism of coumarin to 7-hydroxycoumarin after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081535(CHEMBL3422051)
Affinity DataIC50:  7.34E+3nMAssay Description:Inhibition of human recombinant aromatase using 7-methoxy-trifluoromethylcoumarin as substrate assessed as formation of fluorescent metabolite after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081470(CHEMBL3422046)
Affinity DataIC50:  3.05E+4nMAssay Description:Inhibition of human recombinant aromatase using 7-methoxy-trifluoromethylcoumarin as substrate assessed as formation of fluorescent metabolite after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50435005(CHEMBL2386285)
Affinity DataEC50:  35nMAssay Description:Displacement of fluorescein-labeled ES2 from human recombinant ERbeta receptor after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081536(CHEMBL3422052)
Affinity DataEC50:  1.92E+3nMAssay Description:Displacement of fluorescein-labeled ES2 from human recombinant ERalpha receptor after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081468(CHEMBL3422028)
Affinity DataEC50:  9.5nMAssay Description:Displacement of fluorescein-labeled ES2 from human recombinant ERbeta receptor after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081467(CHEMBL3422029)
Affinity DataEC50:  49nMAssay Description:Displacement of fluorescein-labeled ES2 from human recombinant ERbeta receptor after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081466(CHEMBL3422030)
Affinity DataEC50:  202nMAssay Description:Displacement of fluorescein-labeled ES2 from human recombinant ERbeta receptor after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081464(CHEMBL3422032)
Affinity DataEC50:  182nMAssay Description:Displacement of fluorescein-labeled ES2 from human recombinant ERbeta receptor after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50081463(CHEMBL3422033)
Affinity DataEC50:  50nMAssay Description:Displacement of fluorescein-labeled ES2 from human recombinant ERbeta receptor after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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