Compile Data Set for Download or QSAR
Report error Found 49 Enz. Inhib. hit(s) with all data for entry = 50046440
TargetHistamine H1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112349(CHEMBL3609328)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human histamine H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112348(CHEMBL3609372)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of wild type dephosphorylated form of PAK1 (249 to 545) (unknown origin) expressed in Escherichia coli using 5-Fluo-Ahx-AKRRRLSSLRA-COOH a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112349(CHEMBL3609328)
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human muscarinic M1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112348(CHEMBL3609372)
Affinity DataKd:  7nMAssay Description:Binding affinity to PAK1 (unknown origin) expressed in HEK293 cells after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of recombinant human PAK1 by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of full length PAK1 (unknown origin) by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112352(CHEMBL3609371)
Affinity DataKd:  9.90nMAssay Description:Binding affinity to PAK1 (unknown origin) expressed in HEK293 cells after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human PAK2 by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50: 14nMAssay Description:Inhibition of PAK1 (unknown origin) using Syntide2 peptide as substrate by pyruvate kinase/lactate dehydrogenase coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 6(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50: 17nMAssay Description:Inhibition of PAK6 (unknown origin) using peptide 7 as substrate by pyruvate kinase/lactate dehydrogenase coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 5(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50: 18nMAssay Description:Inhibition of PAK5 (unknown origin) using peptide 7 as substrate by pyruvate kinase/lactate dehydrogenase coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112352(CHEMBL3609371)
Affinity DataIC50: 18nMAssay Description:Inhibition of wild type dephosphorylated form of PAK1 (249 to 545) (unknown origin) expressed in Escherichia coli using 5-Fluo-Ahx-AKRRRLSSLRA-COOH a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50: 19nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human PAK4 kinase domain (300 to 591) using peptide 7 as substrate by pyruvate kinase/lactate dehydr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant human PAK3 by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 40nMAssay Description:Inhibition of full length PAK2 (unknown origin) by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 55nMAssay Description:Inhibition of full length PAK3 (unknown origin) by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50: 99nMAssay Description:Inhibition of PAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112350(CHEMBL3609370)
Affinity DataKd:  130nMAssay Description:Binding affinity to PAK1 (unknown origin) expressed in HEK293 cells after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50: 190nMAssay Description:Inhibition of PAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112350(CHEMBL3609370)
Affinity DataIC50: 190nMAssay Description:Inhibition of wild type dephosphorylated form of PAK1 (249 to 545) (unknown origin) expressed in Escherichia coli using 5-Fluo-Ahx-AKRRRLSSLRA-COOH a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112351(CHEMBL3609330)
Affinity DataIC50: 323nMAssay Description:Inhibition of wild type dephosphorylated form of PAK1 (249 to 545) (unknown origin) expressed in Escherichia coli using 5-Fluo-Ahx-AKRRRLSSLRA-COOH a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112351(CHEMBL3609330)
Affinity DataKd:  340nMAssay Description:Binding affinity to PAK1 (unknown origin) expressed in HEK293 cells after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112348(CHEMBL3609372)
Affinity DataKd:  400nMAssay Description:Binding affinity to PAK2 (unknown origin) expressed in HEK293 cells after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 779nMAssay Description:Inhibition of full length PAK4 (unknown origin) by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112353(CHEMBL3609329)
Affinity DataIC50: 900nMAssay Description:Inhibition of wild type dephosphorylated form of PAK1 (249 to 545) (unknown origin) expressed in Escherichia coli using 5-Fluo-Ahx-AKRRRLSSLRA-COOH a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112353(CHEMBL3609329)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PAK1 (unknown origin) in presence of 1.5 uM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112352(CHEMBL3609371)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to PAK2 (unknown origin) expressed in HEK293 cells after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112354(CHEMBL472940)
Affinity DataIC50: 2.50E+3nMAssay Description:Non-ATP competitive inhibition of full-length human PAK1 assessed as phosphate incorporation onto MBP preincubated for 5 mins followed by Cdc42, MBP,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112353(CHEMBL3609329)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of PAK1 (unknown origin) in presence of 15 uM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112353(CHEMBL3609329)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of wild type phosphorylated form of PAK1 (249 to 545) (unknown origin) expressed in Escherichia coli using 5-Fluo-Ahx-AKRRRLSSLRA-COOH as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 6(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112354(CHEMBL472940)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length human PAK6 assessed as phosphate incorporation onto MBP preincubated for 5 mins followed by Cdc42, MBP, and mixture of ATP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 5(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112354(CHEMBL472940)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length PAK5 (unknown origin) expressed in HEK293 cells assessed as phosphate incorporation onto MBP preincubated for 5 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112354(CHEMBL472940)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PAK4 kinase domain (300 to 591) (unknown origin) assessed as phosphate incorporation onto MBP preincubated for 5 mins followed by Cdc42...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human PAK4 by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112349(CHEMBL3609328)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of wild type dephosphorylated form of PAK1 (249 to 545) (unknown origin) expressed in Escherichia coli using 5-Fluo-Ahx-AKRRRLSSLRA-COOH a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112353(CHEMBL3609329)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of PAK1 (unknown origin) in presence of 150 uM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112348(CHEMBL3609372)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human muscarinic M1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112348(CHEMBL3609372)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human histamine H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112352(CHEMBL3609371)
Affinity DataKd: >4.00E+4nMAssay Description:Binding affinity to PAK3 (unknown origin) expressed in HEK293 cells after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112350(CHEMBL3609370)
Affinity DataKd: >4.00E+4nMAssay Description:Binding affinity to PAK3 (unknown origin) expressed in HEK293 cells after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112351(CHEMBL3609330)
Affinity DataKd: >4.00E+4nMAssay Description:Binding affinity to PAK3 (unknown origin) expressed in HEK293 cells after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112350(CHEMBL3609370)
Affinity DataKd: >4.00E+4nMAssay Description:Binding affinity to PAK2 (unknown origin) expressed in HEK293 cells after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112351(CHEMBL3609330)
Affinity DataKd: >4.00E+4nMAssay Description:Binding affinity to PAK2 (unknown origin) expressed in HEK293 cells after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 6(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112350(CHEMBL3609370)
Affinity DataKd: >4.00E+4nMAssay Description:Binding affinity to PAK6 (unknown origin) expressed in HEK293 cells after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 6(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112351(CHEMBL3609330)
Affinity DataKd: >4.00E+4nMAssay Description:Binding affinity to PAK6 (unknown origin) expressed in HEK293 cells after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112352(CHEMBL3609371)
Affinity DataKd: >4.00E+4nMAssay Description:Binding affinity to PAK4 (unknown origin) expressed in HEK293 cells after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112350(CHEMBL3609370)
Affinity DataKd: >4.00E+4nMAssay Description:Binding affinity to PAK4 (unknown origin) expressed in HEK293 cells after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112351(CHEMBL3609330)
Affinity DataKd: >4.00E+4nMAssay Description:Binding affinity to PAK4 (unknown origin) expressed in HEK293 cells after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112349(CHEMBL3609328)
Affinity DataIC50: 5.40E+4nMAssay Description:Inhibition of wild type phosphorylated form of PAK1 (249 to 545) (unknown origin) expressed in Escherichia coli using 5-Fluo-Ahx-AKRRRLSSLRA-COOH as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)