Found 69 Enz. Inhib. hit(s) with all data for entry = 50006303 
Affinity DataIC50: 10nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Merck Research Laboratories Boston
Curated by ChEMBL
Merck Research Laboratories Boston
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
Affinity DataIC50: 240nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
Affinity DataIC50: 240nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
Affinity DataIC50: 320nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
Affinity DataIC50: 370nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
Affinity DataIC50: 390nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
Affinity DataIC50: 430nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
Affinity DataIC50: 440nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
Affinity DataIC50: 470nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories Boston
Curated by ChEMBL
Merck Research Laboratories Boston
Curated by ChEMBL
Affinity DataIC50: 530nMAssay Description:Binding affinity to human ERG expressed in HEK cells by MK-499 radioligand displacement assayMore data for this Ligand-Target Pair
Affinity DataIC50: 580nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
Affinity DataIC50: 880nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories Boston
Curated by ChEMBL
Merck Research Laboratories Boston
Curated by ChEMBL
Affinity DataIC50: 900nMAssay Description:Binding affinity to human ERG expressed in HEK cells by MK-499 radioligand displacement assayMore data for this Ligand-Target Pair
Affinity DataIC50: 940nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories Boston
Curated by ChEMBL
Merck Research Laboratories Boston
Curated by ChEMBL
Affinity DataIC50: 1.01E+3nMAssay Description:Binding affinity to human ERG expressed in HEK cells by MK-499 radioligand displacement assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.19E+3nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories Boston
Curated by ChEMBL
Merck Research Laboratories Boston
Curated by ChEMBL
Affinity DataIC50: 1.58E+3nMAssay Description:Binding affinity to human ERG expressed in HEK cells by MK-499 radioligand displacement assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories Boston
Curated by ChEMBL
Merck Research Laboratories Boston
Curated by ChEMBL
Affinity DataIC50: 1.83E+3nMAssay Description:Binding affinity to human ERG expressed in HEK cells by MK-499 radioligand displacement assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.01E+3nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories Boston
Curated by ChEMBL
Merck Research Laboratories Boston
Curated by ChEMBL
Affinity DataIC50: 2.61E+3nMAssay Description:Binding affinity to human ERG expressed in HEK cells by MK-499 radioligand displacement assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories Boston
Curated by ChEMBL
Merck Research Laboratories Boston
Curated by ChEMBL
Affinity DataIC50: 2.68E+3nMAssay Description:Binding affinity to human ERG expressed in HEK cells by MK-499 radioligand displacement assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.08E+3nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.14E+3nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories Boston
Curated by ChEMBL
Merck Research Laboratories Boston
Curated by ChEMBL
Affinity DataIC50: 3.22E+3nMAssay Description:Binding affinity to human ERG expressed in HEK cells by MK-499 radioligand displacement assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories Boston
Curated by ChEMBL
Merck Research Laboratories Boston
Curated by ChEMBL
Affinity DataIC50: 3.56E+3nMAssay Description:Binding affinity to human ERG expressed in HEK cells by MK-499 radioligand displacement assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories Boston
Curated by ChEMBL
Merck Research Laboratories Boston
Curated by ChEMBL
Affinity DataIC50: 4.06E+3nMAssay Description:Binding affinity to human ERG expressed in HEK cells by MK-499 radioligand displacement assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories Boston
Curated by ChEMBL
Merck Research Laboratories Boston
Curated by ChEMBL
Affinity DataIC50: 4.45E+3nMAssay Description:Binding affinity to human ERG expressed in HEK cells by MK-499 radioligand displacement assayMore data for this Ligand-Target Pair
