Report error Found 87 Enz. Inhib. hit(s) with all data for entry = 50046306
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 23nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 28nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Binding affinity to wild type GST-tagged HIF-2alpha PAS-B (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibition of inter...More data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 34nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 38nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Binding affinity to wild type GST-tagged HIF-2alpha PAS-B (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibition of inter...More data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 49nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 63nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 70nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 85nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 85nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataIC50: 87nMAssay Description:Binding affinity to wild type GST-tagged HIF-2alpha PAS-B (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibition of inter...More data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataIC50: 97nMAssay Description:Binding affinity to wild type GST-tagged HIF-2alpha PAS-B (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibition of inter...More data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 103nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataIC50: 108nMAssay Description:Binding affinity to wild type GST-tagged HIF-2alpha PAS-B (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibition of inter...More data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 109nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataIC50: 112nMAssay Description:Binding affinity to wild type GST-tagged HIF-2alpha PAS-B (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibition of inter...More data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 116nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 125nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 126nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 159nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 165nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 194nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataIC50: 195nMAssay Description:Binding affinity to wild type GST-tagged HIF-2alpha PAS-B (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibition of inter...More data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 216nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 240nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataIC50: 248nMAssay Description:Binding affinity to wild type GST-tagged HIF-2alpha PAS-B (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibition of inter...More data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 294nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataIC50: 314nMAssay Description:Binding affinity to wild type GST-tagged HIF-2alpha PAS-B (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibition of inter...More data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 327nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 360nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 361nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 393nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 400nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 411nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 487nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 766nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 837nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 883nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of HIF-2alpha in human Hep3B cells assessed as downregulation of EPO mRNA expression by RT-PCR analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity to wild type GST-tagged HIF-2alpha PAS-B (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibition of inter...More data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 1.17E+3nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 1.24E+3nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: 1.41E+3nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: >2.00E+3nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: >2.00E+3nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: >2.00E+3nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: >2.00E+3nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: >2.00E+3nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Human)
University of Texas Southwestern Medical Center
Curated by ChEMBL
University of Texas Southwestern Medical Center
Curated by ChEMBL
Affinity DataKd: >2.00E+3nMAssay Description:Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair






3D Structure (crystal)































