Compile Data Set for Download or QSAR
maximum 50k data
Found 96 Enz. Inhib. hit(s) with all data for entry = 50046747
LigandPNGBDBM50129274(CHEMBL3629745)
Affinity DataIC50:  2nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129274(CHEMBL3629745)
Affinity DataIC50:  2nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 40 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129273(CHEMBL3629744)
Affinity DataIC50:  3nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 40 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129269(CHEMBL3629738 | US9464103, (6aR,7S,10aS)-10a-(4-ch...)
Affinity DataIC50:  3nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129269(CHEMBL3629738 | US9464103, (6aR,7S,10aS)-10a-(4-ch...)
Affinity DataIC50:  3nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129273(CHEMBL3629744)
Affinity DataIC50:  5nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28986(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataIC50:  5nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 afte...More data for this Ligand-Target Pair
LigandPNGBDBM50129278(CHEMBL3629742 | US9464103, (6aR,10aS)-10a-(4-chlor...)
Affinity DataIC50:  5nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129274(CHEMBL3629745)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of gamma-secretase in HEK293 cell membranes using SPC99-Lon as substrate assessed as formation of amyloid beta 40 after 1 hr by electroche...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129269(CHEMBL3629738 | US9464103, (6aR,7S,10aS)-10a-(4-ch...)
Affinity DataIC50:  6nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 40 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129269(CHEMBL3629738 | US9464103, (6aR,7S,10aS)-10a-(4-ch...)
Affinity DataIC50:  6nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 40 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129277(CHEMBL3629739 | US9464103, (6aR,10aS)-10a-(4-chlor...)
Affinity DataIC50:  7nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129272(CHEMBL3629743 | US9464103, (6aR,7S,10aS)-10a-(4-ch...)
Affinity DataIC50:  8nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129273(CHEMBL3629744)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of gamma-secretase in HEK293 cell membranes using SPC99-Lon as substrate assessed as formation of amyloid beta 40 after 1 hr by electroche...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129273(CHEMBL3629744)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of gamma-secretase in HEK293 cell membranes using SPC99-Lon as substrate assessed as formation of amyloid beta 40 after 1 hr by electroche...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129271(CHEMBL3629741 | US9464103, (6aR,10aS)-10a-(4-chlor...)
Affinity DataIC50:  10nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129277(CHEMBL3629739 | US9464103, (6aR,10aS)-10a-(4-chlor...)
Affinity DataIC50:  10nMAssay Description:Inhibition of gamma-secretase in HEK293 cell membranes using SPC99-Lon as substrate assessed as formation of amyloid beta 40 after 1 hr by electroche...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129276(CHEMBL3629737 | US9464103, (6aR,10aS)-10a-(4-chlor...)
Affinity DataIC50:  12nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129272(CHEMBL3629743 | US9464103, (6aR,7S,10aS)-10a-(4-ch...)
Affinity DataIC50:  13nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 40 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129277(CHEMBL3629739 | US9464103, (6aR,10aS)-10a-(4-chlor...)
Affinity DataIC50:  13nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 40 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129269(CHEMBL3629738 | US9464103, (6aR,7S,10aS)-10a-(4-ch...)
Affinity DataIC50:  13.9nMAssay Description:Inhibition of gamma-secretase in HEK293 cell membranes using SPC99-Lon as substrate assessed as formation of amyloid beta 40 after 1 hr by electroche...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129269(CHEMBL3629738 | US9464103, (6aR,7S,10aS)-10a-(4-ch...)
Affinity DataIC50:  14nMAssay Description:Inhibition of gamma-secretase in HEK293 cell membranes using SPC99-Lon as substrate assessed as formation of amyloid beta 40 after 1 hr by electroche...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50166702(2-(1-(4-chlorophenylsulfonyl)cyclohexyl)-1,4-diflu...)
Affinity DataIC50:  14nMAssay Description:Inhibition of gamma-secretase in HEK293 cell membranes using SPC99-Lon as substrate assessed as formation of amyloid beta 40 after 1 hr by electroche...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28986(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataIC50:  14nMAssay Description:Inhibition of gamma-secretase in HEK293 cell membranes using SPC99-Lon as substrate assessed as formation of amyloid beta 40 after 1 hr by electroche...More data for this Ligand-Target Pair
LigandPNGBDBM28986(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataIC50:  15nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 40 afte...More data for this Ligand-Target Pair
LigandPNGBDBM50129278(CHEMBL3629742 | US9464103, (6aR,10aS)-10a-(4-chlor...)
Affinity DataIC50:  17nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 40 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129272(CHEMBL3629743 | US9464103, (6aR,7S,10aS)-10a-(4-ch...)
Affinity DataIC50:  23nMAssay Description:Inhibition of gamma-secretase in HEK293 cell membranes using SPC99-Lon as substrate assessed as formation of amyloid beta 40 after 1 hr by electroche...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129271(CHEMBL3629741 | US9464103, (6aR,10aS)-10a-(4-chlor...)
Affinity DataIC50:  25nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 40 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129278(CHEMBL3629742 | US9464103, (6aR,10aS)-10a-(4-chlor...)
Affinity DataIC50:  26nMAssay Description:Inhibition of gamma-secretase in HEK293 cell membranes using SPC99-Lon as substrate assessed as formation of amyloid beta 40 after 1 hr by electroche...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50166702(2-(1-(4-chlorophenylsulfonyl)cyclohexyl)-1,4-diflu...)
Affinity DataIC50:  27nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129276(CHEMBL3629737 | US9464103, (6aR,10aS)-10a-(4-chlor...)
Affinity DataIC50:  33nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 40 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50166702(2-(1-(4-chlorophenylsulfonyl)cyclohexyl)-1,4-diflu...)
Affinity DataIC50:  41nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 40 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129271(CHEMBL3629741 | US9464103, (6aR,10aS)-10a-(4-chlor...)
Affinity DataIC50:  58nMAssay Description:Inhibition of gamma-secretase in HEK293 cell membranes using SPC99-Lon as substrate assessed as formation of amyloid beta 40 after 1 hr by electroche...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129276(CHEMBL3629737 | US9464103, (6aR,10aS)-10a-(4-chlor...)
Affinity DataIC50:  67nMAssay Description:Inhibition of gamma-secretase in HEK293 cell membranes using SPC99-Lon as substrate assessed as formation of amyloid beta 40 after 1 hr by electroche...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129270(CHEMBL3629740 | US9464103, (6aR,7S,10aS)-10a-(4-ch...)
Affinity DataIC50:  228nMAssay Description:Inhibition of gamma-secretase in HEK293 cell membranes using SPC99-Lon as substrate assessed as formation of amyloid beta 40 after 1 hr by electroche...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129268(CHEMBL3629736)
Affinity DataIC50:  251nMAssay Description:Inhibition of gamma-secretase in HEK293 cell membranes using SPC99-Lon as substrate assessed as formation of amyloid beta 40 after 1 hr by electroche...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50315282(CHEMBL1090209 | N-((6aR,8R,10aS)-10a-(4-chlorophen...)
Affinity DataIC50: <300nMAssay Description:Inhibition of CYP2C9 (unknown origin) preincubated with protein for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM28986(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataIC50: <300nMAssay Description:Inhibition of CYP2C9 (unknown origin) preincubated with protein for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50315282(CHEMBL1090209 | N-((6aR,8R,10aS)-10a-(4-chlorophen...)
Affinity DataIC50: <300nMAssay Description:Inhibition of CYP2C9 (unknown origin) co-incubated with substrate and proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM28986(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataIC50: <300nMAssay Description:Inhibition of CYP2C9 (unknown origin) co-incubated with substrate and proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50129275(CHEMBL3627955)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin) co-incubated with substrate and proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50315282(CHEMBL1090209 | N-((6aR,8R,10aS)-10a-(4-chlorophen...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) preincubated with protein for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50129275(CHEMBL3627955)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin) preincubated with protein for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM28986(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataIC50:  9.30E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) preincubated with protein for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50315282(CHEMBL1090209 | N-((6aR,8R,10aS)-10a-(4-chlorophen...)
Affinity DataIC50:  9.60E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) co-incubated with substrate and proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50129268(CHEMBL3629736)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) co-incubated with substrate and proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50129268(CHEMBL3629736)
Affinity DataIC50:  1.15E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) preincubated with protein for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM28986(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataIC50:  1.66E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) co-incubated with substrate and proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50129275(CHEMBL3627955)
Affinity DataIC50:  1.79E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin) co-incubated with substrate and proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50129274(CHEMBL3629745)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) preincubated with protein for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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