Found 12 Enz. Inhib. hit(s) with all data for entry = 50009798 
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human mPGES-1 expressed in CHO-K1 cells using PGH2 as substrate assessed as PGE2 formation preincubated for 20 mins followed by additio...More data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human mPGES-1 expressed in CHO-K1 cells using PGH2 as substrate assessed as PGE2 formation preincubated for 20 mins followed by additio...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of mPGES-1 in human A549 cells assessed as PGE2-alpha formation preincubated for 60 mins prior to IL-beta stimulation measured after 24 hr...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of mPGES-1 in human A549 cells assessed as PGE2-alpha formation preincubated for 60 mins prior to IL-beta stimulation measured after 24 hr...More data for this Ligand-Target Pair
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
University Jena
Curated by ChEMBL
University Jena
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at FLAP in human PMNC assessed as inhibition of A23187-induced LTB4 biosynthesis pre-incubated for 2 mins followed by addition of...More data for this Ligand-Target Pair
3D Structure (crystal)TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
University Jena
Curated by ChEMBL
University Jena
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at FLAP in human PMNC assessed as inhibition of A23187-induced LTB4 biosynthesis pre-incubated for 2 mins followed by addition of...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of mPGES-1 in human A549 cells assessed as PEG2 formation preincubated for 30 mins followed by recombinant human interleukin 1beta additio...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of mPGES-1 in human A549 cells assessed as PEG2 formation preincubated for 30 mins followed by recombinant human interleukin 1beta additio...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of mPGES-1 in human whole blood cells assessed as PEG2 formation by LC/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of mPGES-1 in human whole blood cells assessed as PEG2 formation by LC/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of ovine COX-1 assessed as 12-HHT formation preincubated for 5 mins followed by addition of arachidonic acid as substrate measured after 5...More data for this Ligand-Target Pair
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of ovine COX-1 assessed as 12-HHT formation preincubated for 5 mins followed by addition of arachidonic acid as substrate measured after 5...More data for this Ligand-Target Pair
