Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50009882
TargetCentromere-associated protein E(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50533247(CHEMBL4470356)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCentromere-associated protein E(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50533247(CHEMBL4470356)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCentromere-associated protein E(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50533251(CHEMBL4579540)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCentromere-associated protein E(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50533251(CHEMBL4579540)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCentromere-associated protein E(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50533246(CHEMBL4549646)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCentromere-associated protein E(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50533246(CHEMBL4549646)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCentromere-associated protein E(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50533249(CHEMBL4468555)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCentromere-associated protein E(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50533249(CHEMBL4468555)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCentromere-associated protein E(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50533248(CHEMBL4515745)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCentromere-associated protein E(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50533248(CHEMBL4515745)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCentromere-associated protein E(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50533245(CHEMBL4579162)
Affinity DataIC50: 14nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCentromere-associated protein E(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50533245(CHEMBL4579162)
Affinity DataIC50: 14nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCentromere-associated protein E(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50533244(CHEMBL4466617)
Affinity DataIC50: 19nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCentromere-associated protein E(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50533244(CHEMBL4466617)
Affinity DataIC50: 19nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCentromere-associated protein E(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50533250(CHEMBL4483703)
Affinity DataIC50: 24nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCentromere-associated protein E(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50533250(CHEMBL4483703)
Affinity DataIC50: 24nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCentromere-associated protein E(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50533249(CHEMBL4468555)
Affinity DataEC50:  39nMAssay Description:Inhibition of CENP-E in human HeLa cells assessed as HH3 phosphorylated levels after 24 hrs by FACS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCentromere-associated protein E(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50533249(CHEMBL4468555)
Affinity DataEC50:  39nMAssay Description:Inhibition of CENP-E in human HeLa cells assessed as HH3 phosphorylated levels after 24 hrs by FACS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCentromere-associated protein E(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50533248(CHEMBL4515745)
Affinity DataEC50:  79nMAssay Description:Inhibition of CENP-E in human HeLa cells assessed as HH3 phosphorylated levels after 24 hrs by FACS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCentromere-associated protein E(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50533248(CHEMBL4515745)
Affinity DataEC50:  79nMAssay Description:Inhibition of CENP-E in human HeLa cells assessed as HH3 phosphorylated levels after 24 hrs by FACS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed