Found 10 Enz. Inhib. hit(s) with all data for entry = 50010251 TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
The Center For Combinatorial Chemistry And Drug Discovery Of Jilin University
Curated by ChEMBL
The Center For Combinatorial Chemistry And Drug Discovery Of Jilin University
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of N-terminal His6-tagged human SETD8 (191 to 352 residues) expressed in Escherichia coli Rosseta-2(DE3) cells using histone peptide subst...More data for this Ligand-Target Pair
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
The Center For Combinatorial Chemistry And Drug Discovery Of Jilin University
Curated by ChEMBL
The Center For Combinatorial Chemistry And Drug Discovery Of Jilin University
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of N-terminal His6-tagged human SETD8 (191 to 352 residues) expressed in Escherichia coli Rosseta-2(DE3) cells using histone peptide subst...More data for this Ligand-Target Pair
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
The Center For Combinatorial Chemistry And Drug Discovery Of Jilin University
Curated by ChEMBL
The Center For Combinatorial Chemistry And Drug Discovery Of Jilin University
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibition of N-terminal His6-tagged human SETD8 (191 to 352 residues) expressed in Escherichia coli Rosseta-2(DE3) cells using histone peptide subst...More data for this Ligand-Target Pair
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
The Center For Combinatorial Chemistry And Drug Discovery Of Jilin University
Curated by ChEMBL
The Center For Combinatorial Chemistry And Drug Discovery Of Jilin University
Curated by ChEMBL
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of SETD8 (unknown origin) using biotin-labeled histone H4 (1 to 24 residues) as substrate incubated for 1 hr in presence of [3H-Me]SAM by ...More data for this Ligand-Target Pair
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
The Center For Combinatorial Chemistry And Drug Discovery Of Jilin University
Curated by ChEMBL
The Center For Combinatorial Chemistry And Drug Discovery Of Jilin University
Curated by ChEMBL
Affinity DataIC50: 3.90E+4nMAssay Description:Inhibition of SETD8 (unknown origin) using biotin-labeled histone H4 (1 to 24 residues) as substrate in presence of [3H-Me]SAM by scintillation proxi...More data for this Ligand-Target Pair
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
The Center For Combinatorial Chemistry And Drug Discovery Of Jilin University
Curated by ChEMBL
The Center For Combinatorial Chemistry And Drug Discovery Of Jilin University
Curated by ChEMBL
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of SETD8 (unknown origin) using biotin-labeled histone H4 (1 to 24 residues) as substrate in presence of [3H-Me]SAM by scintillation proxi...More data for this Ligand-Target Pair
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
The Center For Combinatorial Chemistry And Drug Discovery Of Jilin University
Curated by ChEMBL
The Center For Combinatorial Chemistry And Drug Discovery Of Jilin University
Curated by ChEMBL
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of SETD8 (unknown origin) using biotin-labeled histone H4 (1 to 24 residues) as substrate in presence of [3H-Me]SAM by scintillation proxi...More data for this Ligand-Target Pair
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
The Center For Combinatorial Chemistry And Drug Discovery Of Jilin University
Curated by ChEMBL
The Center For Combinatorial Chemistry And Drug Discovery Of Jilin University
Curated by ChEMBL
Affinity DataEC50: <5.00E+3nMAssay Description:Inhibition of SETD8 in HEK293T cells assessed as reduction in H4K20me level after 2 to 3 days by Western blot analysisMore data for this Ligand-Target Pair
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
The Center For Combinatorial Chemistry And Drug Discovery Of Jilin University
Curated by ChEMBL
The Center For Combinatorial Chemistry And Drug Discovery Of Jilin University
Curated by ChEMBL
Affinity DataEC50: <1.00E+3nMAssay Description:Inhibition of SETD8 in HEK293T cells assessed as reduction in H4K20me level after 2 to 3 days by Western blot analysisMore data for this Ligand-Target Pair
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
The Center For Combinatorial Chemistry And Drug Discovery Of Jilin University
Curated by ChEMBL
The Center For Combinatorial Chemistry And Drug Discovery Of Jilin University
Curated by ChEMBL
Affinity DataEC50: <5.00E+3nMAssay Description:Inhibition of SETD8 in HEK293T cells assessed as reduction in H4K20me level after 2 to 3 days by Western blot analysisMore data for this Ligand-Target Pair
