Compile Data Set for Download or QSAR
Report error Found 25 Enz. Inhib. hit(s) with all data for entry = 50018900
TargetMuscarinic acetylcholine receptor M4(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50613714(CHEMBL5284390)
Affinity DataEC50: >10nMAssay Description:Positive allosteric modulator activity at human M4 receptor expressed in CHO cells co-expressing Gqi5 in presence of EC20 concentration of acetylchol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50451549(CHEMBL4207737)
Affinity DataEC50:  27nMAssay Description:Positive allosteric modulator activity at rat M4 receptor expressed in CHO cells co-expressing Gqi5 in presence of EC20 concentration of acetylcholin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50613707(CHEMBL5276239)
Affinity DataEC50:  41nMAssay Description:Positive allosteric modulator activity at human M4 receptor expressed in CHO cells co-expressing Gqi5 in presence of EC20 concentration of acetylchol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50613709(CHEMBL5269998)
Affinity DataEC50:  43nMAssay Description:Positive allosteric modulator activity at human M4 receptor expressed in CHO cells co-expressing Gqi5 in presence of EC20 concentration of acetylchol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50451549(CHEMBL4207737)
Affinity DataEC50:  56nMAssay Description:Positive allosteric modulator activity at human M4 receptor expressed in CHO cells co-expressing Gqi5 in presence of EC20 concentration of acetylchol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50613713(CHEMBL5282936)
Affinity DataEC50:  59nMAssay Description:Positive allosteric modulator activity at human M4 receptor expressed in CHO cells co-expressing Gqi5 in presence of EC20 concentration of acetylchol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50451549(CHEMBL4207737)
Affinity DataEC50:  79nMAssay Description:Positive allosteric modulator activity at human M4 receptor expressed in CHO cells co-expressing Gqi5 in presence of EC20 concentration of acetylchol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50613708(CHEMBL5285036)
Affinity DataEC50:  84nMAssay Description:Positive allosteric modulator activity at human M4 receptor expressed in CHO cells co-expressing Gqi5 in presence of EC20 concentration of acetylchol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50613706(CHEMBL5272517)
Affinity DataEC50:  91nMAssay Description:Positive allosteric modulator activity at human M4 receptor expressed in CHO cells co-expressing Gqi5 in presence of EC20 concentration of acetylchol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50613705(CHEMBL5265891)
Affinity DataEC50:  97nMAssay Description:Positive allosteric modulator activity at human M4 receptor expressed in CHO cells co-expressing Gqi5 in presence of EC20 concentration of acetylchol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50613710(CHEMBL5288291)
Affinity DataEC50:  100nMAssay Description:Positive allosteric modulator activity at human M4 receptor expressed in CHO cells co-expressing Gqi5 in presence of EC20 concentration of acetylchol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50207520(CHEMBL3933538)
Affinity DataEC50:  130nMAssay Description:Positive allosteric modulator activity at human M4 receptor expressed in CHO cells co-expressing Gqi5 in presence of EC20 concentration of acetylchol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50613712(CHEMBL5269733)
Affinity DataEC50:  142nMAssay Description:Positive allosteric modulator activity at human M4 receptor expressed in CHO cells co-expressing Gqi5 in presence of EC20 concentration of acetylchol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50613711(CHEMBL5267403)
Affinity DataEC50:  239nMAssay Description:Positive allosteric modulator activity at human M4 receptor expressed in CHO cells co-expressing Gqi5 in presence of EC20 concentration of acetylchol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50613715(CHEMBL5265850)
Affinity DataEC50:  508nMAssay Description:Positive allosteric modulator activity at human M4 receptor expressed in CHO cells co-expressing Gqi5 in presence of EC20 concentration of acetylchol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50451549(CHEMBL4207737)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulator activity at rat M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as maximal response to ACh by calcium mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50451549(CHEMBL4207737)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulator activity at human M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as maximal response to ACh by calcium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50451549(CHEMBL4207737)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP34A in human liver microsomes using midazolam as substrate incubated for 15 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50451549(CHEMBL4207737)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate incubated for 15 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50451549(CHEMBL4207737)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate incubated for 15 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50451549(CHEMBL4207737)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate incubated for 15 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50451549(CHEMBL4207737)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of hERG cardiac ion channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50451549(CHEMBL4207737)
Affinity DataEC50: >5.00E+4nMAssay Description:Activation of CYP1A2 in human hepatocyte using phenacetin as substrate preincubated for 5 days followed by substrate addition and measured after 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50451549(CHEMBL4207737)
Affinity DataEC50: >5.00E+4nMAssay Description:Activation of CYP34A in human hepatocyte using midazolam as substrate preincubated for 5 days followed by substrate addition and measured after 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCytochrome P450 2B6(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50451549(CHEMBL4207737)
Affinity DataEC50: >5.00E+4nMAssay Description:Activation of CYP2B6 in human hepatocyte using bupropion as substrate preincubated for 5 days followed by substrate addition and measured after 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed