Compile Data Set for Download or QSAR
Report error Found 29 Enz. Inhib. hit(s) with all data for entry = 50049238
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 94507BDBM94507(SMR000326757 | Carbetapentane citrate | CHEMBL7323...)
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of MPP+ after 1 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 36880BDBM36880(cid_2406 | SMR000058374 | 2,4-dichloro-6-(3,5-dich...)
Affinity DataIC50: 2.23E+3nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of MPP+ after 1 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 151585BDBM151585(US8987315, Ketoconazole | US9180183, Ketoconazole ...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50063753BDBM50063753(Closantel | N-{5-Chloro-4-[(4-chloro-phenyl)-cyano...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of MPP+ after 1 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25759BDBM25759([3-(9H-carbazol-4-yloxy)-2-hydroxypropyl][2-(2-met...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of MPP+ after 1 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50325274BDBM50325274(Dobutrex | 4-{2-[3-(4-Hydroxy-phenyl)-1-methyl-pro...)
Affinity DataIC50: 4.17E+3nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50225293BDBM50225293(CHEBI:5553 | Guanabenz | WY-8678)
Affinity DataIC50: 4.85E+3nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of MPP+ after 1 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4814BDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31775BDBM31775(Grisefuline | Amudane | Fulvicin | Griseofulvin)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50010859BDBM50010859(CHEMBL11 | Imipramin | IMIPRAMINE HYDROCHLORIDE | ...)
Affinity DataIC50: 7.95E+3nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of MPP+ after 1 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50303912BDBM50303912(4-chloro-2-(5-chloro-2-hydroxybenzyl)phenol | Dich...)
Affinity DataIC50: 8.41E+3nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of MPP+ after 1 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50237286BDBM50237286(Acamylophenine | Acamylophenine HCl | Camylofin)
Affinity DataIC50: 9.12E+3nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of MPP+ after 1 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 35229BDBM35229(Desmethylimipramine | 3-(10,11-dihydro-5H-dibenzo[...)
Affinity DataIC50: 9.18E+3nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of MPP+ after 1 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50366613BDBM50366613(DEXTROMETHORPHAN)
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of MPP+ after 1 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 112780BDBM112780(US8629135, SW-07)
Affinity DataIC50: 1.12E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of MPP+ after 1 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31774BDBM31774(cid_2812 | CHEMBL104 | Canesten | Mycelex | Lotrim...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 18512BDBM18512(cid_4993 | CHEMBL36 | 5-(4-chlorophenyl)-6-ethylpy...)
Affinity DataIC50: 1.36E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of MPP+ after 1 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50033110BDBM50033110(N-{3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)(methy...)
Affinity DataIC50: 1.49E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of MPP+ after 1 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50237287BDBM50237287(Cloperastine | Cloperastine Fendizoate | Cloperast...)
Affinity DataIC50: 1.49E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of MPP+ after 1 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50067133BDBM50067133(CHEMBL631 | 1-[2-(2-Hydroxy-3-propylamino-propoxy)...)
Affinity DataIC50: 1.55E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 5446BDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 1.62E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of MPP+ after 1 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50225285BDBM50225285(CHEBI:3757 | Catapres | Catapres-Tts-1 | Catapres-...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 8958BDBM8958(CHEMBL1206 | 10-(2-diethylaminopropyl)phenothiazin...)
Affinity DataIC50: 2.05E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of MPP+ after 1 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 8961BDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 2.17E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of MPP+ after 1 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 18069BDBM18069(CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...)
Affinity DataIC50: 5.07E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50017041BDBM50017041(1,2,3,4-Tetrahydro-1-(phenylmethyl)isoquinoline | ...)
Affinity DataIC50: 8.21E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of MPP+ after 1 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 181119BDBM181119(US9138393, Cimetidine | US9144538, Cimetidine)
Affinity DataIC50: 1.49E+5nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of YM155 after 1 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50229665BDBM50229665(N,N-dimethylimidodicarbonimidic diamide | 1,1-Dime...)
Affinity DataIC50: 1.23E+6nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of MPP+ after 1 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50373877BDBM50373877(Vitamin B 1 | Betaxin | Thiamine | ThOH | THIAMINE...)
Affinity DataIC50: 4.35E+6nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of MPP+ after 1 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)