Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 50035705
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50029050(4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2...)
Affinity DataKi:  5nMAssay Description:Binding affinity against alpha 2-Adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]clonidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019057((+/-)4-Fluoro-5-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataKi:  9nMAssay Description:Binding affinity against alpha 2-Adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]clonidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019061(CHEMBL281232 | 4-(2-Amino-1-hydroxy-ethyl)-5-fluor...)
Affinity DataKi:  12nMAssay Description:Binding affinity against alpha 2-Adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]clonidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50029051(4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol | ...)
Affinity DataKi:  30nMAssay Description:Binding affinity against alpha 2-Adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]clonidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Guinea pig)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019059(3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-benzene...)
Affinity DataEC50:  40nMAssay Description:Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetBeta-1/Beta-2/Beta-3 adrenergic receptor(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019059(3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-benzene...)
Affinity DataEC50:  40nMAssay Description:Agonistic potency at beta adrenergic receptor for the stimulation of accumulation of cyclic AMP in cultured C6 glioma cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019059(3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-benzene...)
Affinity DataKi:  66nMAssay Description:Binding affinity against alpha-2 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]clonidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019057((+/-)4-Fluoro-5-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataEC50:  100nMAssay Description:Agonistic potency at alpha 2-Adrenergic receptor for inhibition of 10 uM forskolin-elicited stimulation of adenylate cyclase in human platelet membra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetBeta-1/Beta-2/Beta-3 adrenergic receptor(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50029050(4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2...)
Affinity DataEC50:  230nMAssay Description:Agonistic potency at beta adrenergic receptor for the stimulation of accumulation of cyclic AMP in cultured C6 glioma cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-1 adrenergic receptor(Guinea pig)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50029050(4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2...)
Affinity DataEC50:  260nMAssay Description:Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-1 adrenergic receptor(Guinea pig)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019060(CHEMBL287587 | 4-(2-Amino-1-hydroxy-ethyl)-3-fluor...)
Affinity DataEC50:  300nMAssay Description:Beta-1 adrenergic receptor agonist activity by stimulation of contraction rate of isolated guinea pig atrial preparationsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50029050(4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2...)
Affinity DataEC50:  300nMAssay Description:Agonistic potency at alpha 2-Adrenergic receptor for inhibition of 10 uM forskolin-elicited stimulation of adenylate cyclase in human platelet membra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-1 adrenergic receptor(Guinea pig)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019060(CHEMBL287587 | 4-(2-Amino-1-hydroxy-ethyl)-3-fluor...)
Affinity DataKi:  350nMAssay Description:Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Guinea pig)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50029051(4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol | ...)
Affinity DataEC50:  350nMAssay Description:Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Guinea pig)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50029051(4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol | ...)
Affinity DataKi:  400nMAssay Description:Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50029050(4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2...)
Affinity DataEC50:  400nMAssay Description:Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019060(CHEMBL287587 | 4-(2-Amino-1-hydroxy-ethyl)-3-fluor...)
Affinity DataKi:  700nMAssay Description:Binding affinity against alpha 2-Adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]clonidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019057((+/-)4-Fluoro-5-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataKi:  700nMAssay Description:Binding affinity against alpha-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]- WB-4101More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019057((+/-)4-Fluoro-5-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataEC50:  800nMAssay Description:Binding affinity against alpha-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]- WB-4101More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetBeta-1/Beta-2/Beta-3 adrenergic receptor(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019057((+/-)4-Fluoro-5-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataEC50: >1.50E+3nMAssay Description:Agonistic potency at beta adrenergic receptor for the stimulation of accumulation of cyclic AMP in cultured C6 glioma cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50029051(4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol | ...)
Affinity DataKi:  1.50E+3nMAssay Description:Binding affinity against alpha-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]- WB-4101More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019061(CHEMBL281232 | 4-(2-Amino-1-hydroxy-ethyl)-5-fluor...)
Affinity DataKi:  1.50E+3nMAssay Description:Binding affinity against alpha-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]- WB-4101More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Guinea pig)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019057((+/-)4-Fluoro-5-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataEC50: >1.50E+3nMAssay Description:Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Guinea pig)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019059(3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-benzene...)
Affinity DataKi:  1.80E+3nMAssay Description:Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50029050(4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2...)
Affinity DataKi:  2.00E+3nMAssay Description:Binding affinity against alpha-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]- WB-4101More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-1 adrenergic receptor(Guinea pig)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019061(CHEMBL281232 | 4-(2-Amino-1-hydroxy-ethyl)-5-fluor...)
Affinity DataKi: >3.00E+3nMAssay Description:Binding affinity against beta-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of Dihydro-[3H]-alprenololMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Guinea pig)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50029050(4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2...)
Affinity DataKi:  3.00E+3nMAssay Description:Binding affinity against beta-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of Dihydro-[3H]-alprenololMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAlpha-1A adrenergic receptor(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019059(3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-benzene...)
Affinity DataEC50:  3.30E+3nMAssay Description:Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019059(3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-benzene...)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonistic potency at alpha 2-Adrenergic receptor for inhibition of 10 uM forskolin-elicited stimulation of adenylate cyclase in human platelet membra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019059(3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-benzene...)
Affinity DataKi:  1.65E+4nMAssay Description:Binding affinity against alpha-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]- WB-4101More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Guinea pig)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019061(CHEMBL281232 | 4-(2-Amino-1-hydroxy-ethyl)-5-fluor...)
Affinity DataEC50:  3.60E+4nMAssay Description:Beta-1 adrenergic receptor agonist activity by stimulation of contraction rate of isolated guinea pig atrial preparationsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019060(CHEMBL287587 | 4-(2-Amino-1-hydroxy-ethyl)-3-fluor...)
Affinity DataKi: >5.00E+4nMAssay Description:Binding affinity against alpha-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]- WB-4101More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Guinea pig)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019057((+/-)4-Fluoro-5-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataKi:  6.30E+4nMAssay Description:Binding affinity against beta-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of Dihydro-[3H]-alprenololMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019060(CHEMBL287587 | 4-(2-Amino-1-hydroxy-ethyl)-3-fluor...)
Affinity DataEC50:  7.10E+4nMAssay Description:Binding affinity against alpha-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]- WB-4101More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019061(CHEMBL281232 | 4-(2-Amino-1-hydroxy-ethyl)-5-fluor...)
Affinity DataEC50:  1.25E+5nMAssay Description:Binding affinity against alpha-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]- WB-4101More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed