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Found 121 Enz. Inhib. hit(s) with all data for entry = 50000654
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257064(CHEMBL2386850)
Affinity DataKi:  4.40nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257064(CHEMBL2386850)
Affinity DataKi:  240nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257087(CHEMBL4102569)
Affinity DataKi:  388nMAssay Description:Displacement of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat mGlu5 receptor expressed in HEK293A cell membranes after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257058(CHEMBL2386849)
Affinity DataIC50:  3.10nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257058(CHEMBL2386849)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using (R)-bufuralol as substrate preincubated for 15 mins measured after 8 mins in presence or absence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257041(CHEMBL4077672)
Affinity DataIC50:  3.5nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257041(CHEMBL4077672)
Affinity DataIC50:  3.60nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257059(CHEMBL4082854)
Affinity DataIC50:  6.80nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257059(CHEMBL4082854)
Affinity DataIC50:  6.80nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257080(CHEMBL4096818)
Affinity DataIC50:  7.20nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257080(CHEMBL4096818)
Affinity DataIC50:  7.20nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257063(CHEMBL4076771)
Affinity DataIC50:  9.10nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257063(CHEMBL4076771)
Affinity DataIC50:  9.10nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257044(CHEMBL2386772)
Affinity DataIC50:  9.30nMAssay Description:Displacement of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat mGlu5 receptor expressed in HEK293A cell membranes after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257044(CHEMBL2386772)
Affinity DataIC50:  9.30nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257079(CHEMBL4100830)
Affinity DataIC50:  9.5nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257079(CHEMBL4100830)
Affinity DataIC50:  9.60nMAssay Description:Inhibition of human Nav1.5 at tonic phase expressed in CHO cells by automated patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257082(CHEMBL4093386)
Affinity DataIC50:  9.80nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257082(CHEMBL4093386)
Affinity DataIC50:  10nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257045(CHEMBL4095685)
Affinity DataIC50:  11nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257064(CHEMBL2386850)
Affinity DataIC50:  11nMAssay Description:Inhibition of human ERG expressed in CHO cells by automated patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257045(CHEMBL4095685)
Affinity DataIC50:  11nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257064(CHEMBL2386850)
Affinity DataIC50:  14nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of glutamate induced-calcium mobilization pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257061(CHEMBL4062697)
Affinity DataIC50:  19nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257061(CHEMBL4062697)
Affinity DataIC50:  19nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257062(CHEMBL4103707)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant DAT expressed in CHO-S cells assessed as reduction in [3H]-dopamine uptake preincubated for 20 mins followed by [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257062(CHEMBL4103707)
Affinity DataIC50:  20nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50442525(CHEMBL2440659 | US8796295, Table 2: Compound: 1)
Affinity DataIC50:  24nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50442525(CHEMBL2440659 | US8796295, Table 2: Compound: 1)
Affinity DataIC50:  24nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257083(CHEMBL4084619)
Affinity DataIC50:  32nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257083(CHEMBL4084619)
Affinity DataIC50:  32nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 5 mins followed by NADPH addition measured after 8 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257043(CHEMBL2386771)
Affinity DataIC50:  33nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257043(CHEMBL2386771)
Affinity DataIC50:  33nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257085(CHEMBL4070410)
Affinity DataIC50:  48nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257085(CHEMBL4070410)
Affinity DataIC50:  48nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 15 mins measured after 8 mins in presence or absence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257060(CHEMBL4090661)
Affinity DataIC50:  54nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257060(CHEMBL4090661)
Affinity DataIC50:  54nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257040(CHEMBL4071866)
Affinity DataIC50:  60nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257040(CHEMBL4071866)
Affinity DataIC50:  60nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257081(CHEMBL4089038)
Affinity DataIC50:  98nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257081(CHEMBL4089038)
Affinity DataIC50:  98nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257041(CHEMBL4077672)
Affinity DataIC50:  100nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using tacrine as substrate preincubated for 5 mins followed by NADPH addition measured after 8 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257079(CHEMBL4100830)
Affinity DataIC50: <100nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using tacrine as substrate preincubated for 5 mins followed by NADPH addition measured after 8 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50442525(CHEMBL2440659 | US8796295, Table 2: Compound: 1)
Affinity DataIC50: <100nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using tacrine as substrate preincubated for 5 mins followed by NADPH addition measured after 8 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM107244(US8598345, 200 | US8598345, Table 1-30/2-4)
Affinity DataIC50: <100nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using tacrine as substrate preincubated for 5 mins followed by NADPH addition measured after 8 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257086(CHEMBL4076802)
Affinity DataIC50:  158nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257086(CHEMBL4076802)
Affinity DataIC50:  158nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257080(CHEMBL4096818)
Affinity DataIC50:  200nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using tacrine as substrate preincubated for 5 mins followed by NADPH addition measured after 8 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM107244(US8598345, 200 | US8598345, Table 1-30/2-4)
Affinity DataIC50:  200nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University Institute Of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257058(CHEMBL2386849)
Affinity DataIC50:  200nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using tacrine as substrate preincubated for 5 mins followed by NADPH addition measured after 8 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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