Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50022587
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of N-terminal 6His-tagged wild type TRKA (486 to 786 residues) (unknown origin) expressed in Escherichia coli incubated for 60 mins by [ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of N-terminal 6His-tagged wild type TRKA (486 to 786 residues) (unknown origin) expressed in Escherichia coli incubated for 60 mins by [ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50: 1.40nMAssay Description:Binding affinity to His-tagged recombinant wildtype human TRKC kinase domain incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of wildtype human extracellular domain deleted TRKA expressed in mouse NIH3T3 cells assessed as reduction in TRKA phosphorylation incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50: 1.90nMAssay Description:Binding affinity to wildtype TRKB (unknown origin) kinase domain incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50: 2nMAssay Description:Inhibition of N-terminal 6His-tagged TRKA G595R mutant (486 to 786 residues) (unknown origin) expressed in Escherichia coli incubated for 60 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of N-terminal 6His-tagged wild type TRKC (506 to 829 residues) (unknown origin) expressed in Escherichia coli incubated for 60 mins by [ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of N-terminal 6His-tagged wild type TRKC (506 to 829 residues) (unknown origin) expressed in Escherichia coli incubated for 60 mins by [ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50: 3.70nMAssay Description:Binding affinity to His-tagged recombinant wildtype human TRKA kinase domain incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 4.20nMAssay Description:Binding affinity to His-tagged recombinant wildtype human TRKC kinase domain incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 4.20nMAssay Description:Binding affinity to wildtype TRKB (unknown origin) kinase domain incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 5nMAssay Description:Inhibition of wildtype human extracellular domain deleted TRKA expressed in mouse NIH3T3 cells assessed as reduction in TRKA phosphorylation incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human extracellular domain deleted TRKA G595R mutant expressed in mouse NIH3T3 cells assessed as reduction in TRKA phosphorylation incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human extracellular domain deleted TRKA F589L mutant expressed in mouse NIH3T3 cells assessed as reduction in TRKA phosphorylation incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 9.10nMAssay Description:Binding affinity to His-tagged recombinant wildtype human TRKA kinase domain incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of N-terminal 6His-tagged TRKA G667C mutant (486 to 786 residues) (unknown origin) expressed in Escherichia coli incubated for 60 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 46nMAssay Description:Inhibition of N-terminal 6His-tagged TRKA G667C mutant (486 to 786 residues) (unknown origin) expressed in Escherichia coli incubated for 60 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 47nMAssay Description:Inhibition of human extracellular domain deleted TRKA F589L mutant expressed in mouse NIH3T3 cells assessed as reduction in TRKA phosphorylation incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50: 64nMAssay Description:Inhibition of human extracellular domain deleted TRKA G667C mutant expressed in mouse NIH3T3 cells assessed as reduction in TRKA phosphorylation incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 69nMAssay Description:Inhibition of N-terminal 6His-tagged TRKA G595R mutant (486 to 786 residues) (unknown origin) expressed in Escherichia coli incubated for 60 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 315nMAssay Description:Inhibition of human extracellular domain deleted TRKA G667C mutant expressed in mouse NIH3T3 cells assessed as reduction in TRKA phosphorylation incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 819nMAssay Description:Inhibition of human extracellular domain deleted TRKA G595R mutant expressed in mouse NIH3T3 cells assessed as reduction in TRKA phosphorylation incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed