Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with all data for entry = 50002270
TargetATP-dependent translocase ABCB1(Human)
Csir - Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50292495(((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...)
Affinity DataIC50: 170nMAssay Description:Inhibition of [125I]IAAP labeling to human MDR1 expressed in baculovirus infected insect cell membranes by electrophoresis methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Csir - Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50292495(((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...)
Affinity DataIC50: 210nMAssay Description:Inhibition of human MDR1 ATPase activity expressed in baculovirus infected insect cells preincubated for 30 mins followed by ATP addition measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Csir - Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50292495(((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...)
Affinity DataIC50: 680nMAssay Description:Displacement of 8-azido[alpha-32P]ATP from human MDR1 expressed in baculovirus infected insect cell membranes by phosphorimaging methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Csir - Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50456439(CHEMBL4206925)
Affinity DataKi:  2.80E+3nMAssay Description:Inhibition of human MDR1 expressed in pig LLC-PK1 cells assessed as reduction in calcein-AM efflux preincubated for 30 mins followed by calcein-AM ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Csir - Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50456439(CHEMBL4206925)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of human MDR1 expressed in pig LLC-PK1 cells assessed as reduction in [3H]vinblastine efflux after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Csir - Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50017712(Apoplon | 3,4,5-trimethoxybenzoyl methyl reserpate...)
Affinity DataIC50: 1.26E+4nMAssay Description:Inhibition of BCRP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed