Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 50002121
TargetAurora kinase A(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453822(CHEMBL3969370)
Affinity DataEC50:  5.80nMAssay Description:Inhibition of Aurora A auto-phosphorylation in human HCT116 cells after 4 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453822(CHEMBL3969370)
Affinity DataEC50:  7.10nMAssay Description:Inhibition of Aurora B in human HCT116 cells assessed as reduction in histone H3 phosphorylation at S10 residues after 4 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453821(CHEMBL4206831)
Affinity DataEC50:  11nMAssay Description:Inhibition of Aurora B in human HCT116 cells assessed as reduction in histone H3 phosphorylation at S10 residues after 4 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50059435(CHEMBL3393498)
Affinity DataEC50:  27nMAssay Description:Inhibition of Aurora B in human HCT116 cells assessed as reduction in histone H3 phosphorylation at S10 residues after 4 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453822(CHEMBL3969370)
Affinity DataIC50: 29nMAssay Description:Inhibition of recombinant full length His-tagged human Aurora B expressed in baculovirus expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50059435(CHEMBL3393498)
Affinity DataIC50: 34nMAssay Description:Inhibition of recombinant full length His-tagged human Aurora B expressed in baculovirus expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453821(CHEMBL4206831)
Affinity DataEC50:  38nMAssay Description:Inhibition of Aurora A auto-phosphorylation in human HCT116 cells after 4 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase B(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453821(CHEMBL4206831)
Affinity DataIC50: 41nMAssay Description:Inhibition of recombinant full length His-tagged human Aurora B expressed in baculovirus expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453822(CHEMBL3969370)
Affinity DataIC50: 44nMAssay Description:Inhibition of recombinant full length His-tagged human Aurora A expressed in baculovirus expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK4(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453822(CHEMBL3969370)
Affinity DataIC50: 44nMAssay Description:Inhibition of GST-tagged human PLK4 (1 to 836 residues) by Lanthascreen binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453821(CHEMBL4206831)
Affinity DataIC50: 52nMAssay Description:Inhibition of recombinant full length His-tagged human Aurora A expressed in baculovirus expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase C(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453821(CHEMBL4206831)
Affinity DataIC50: 53nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora C expressed in baculovirus expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAurora kinase C(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453822(CHEMBL3969370)
Affinity DataIC50: 63nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora C expressed in baculovirus expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50059435(CHEMBL3393498)
Affinity DataIC50: 75nMAssay Description:Inhibition of recombinant full length His-tagged human Aurora A expressed in baculovirus expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PLK4(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453821(CHEMBL4206831)
Affinity DataIC50: 82nMAssay Description:Inhibition of GST-tagged human PLK4 (1 to 836 residues) by Lanthascreen binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAurora kinase C(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50059435(CHEMBL3393498)
Affinity DataIC50: 91nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora C expressed in baculovirus expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50059435(CHEMBL3393498)
Affinity DataEC50:  106nMAssay Description:Inhibition of Aurora A auto-phosphorylation in human HCT116 cells after 4 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453821(CHEMBL4206831)
Affinity DataIC50: 714nMAssay Description:Inhibition of recombinant GST-tagged human LRRK2 (970 to 2527 residues) catalytic domain expressed in baculovirus expression system by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453822(CHEMBL3969370)
Affinity DataIC50: 754nMAssay Description:Inhibition of recombinant GST-tagged human LRRK2 (970 to 2527 residues) catalytic domain expressed in baculovirus expression system by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453821(CHEMBL4206831)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of BRD4 (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453822(CHEMBL3969370)
Affinity DataIC50: 3.70E+4nMAssay Description:Inhibition of BRD4 (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed