Found 45 Enz. Inhib. hit(s) with all data for entry = 50000826 TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Sumitomo Dainippon Pharma
Curated by ChEMBL
Sumitomo Dainippon Pharma
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium mobilization...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Sumitomo Dainippon Pharma
Curated by ChEMBL
Sumitomo Dainippon Pharma
Curated by ChEMBL
Affinity DataIC50: 38nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium mobilization...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Sumitomo Dainippon Pharma
Curated by ChEMBL
Sumitomo Dainippon Pharma
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium mobilization...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Sumitomo Dainippon Pharma
Curated by ChEMBL
Sumitomo Dainippon Pharma
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium mobilization...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Sumitomo Dainippon Pharma
Curated by ChEMBL
Sumitomo Dainippon Pharma
Curated by ChEMBL
Affinity DataIC50: 54nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium mobilization...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Sumitomo Dainippon Pharma
Curated by ChEMBL
Sumitomo Dainippon Pharma
Curated by ChEMBL
Affinity DataIC50: 58nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium mobilization...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Sumitomo Dainippon Pharma
Curated by ChEMBL
Sumitomo Dainippon Pharma
Curated by ChEMBL
Affinity DataIC50: 63nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium mobilization...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Sumitomo Dainippon Pharma
Curated by ChEMBL
Sumitomo Dainippon Pharma
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium mobilization...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Sumitomo Dainippon Pharma
Curated by ChEMBL
Sumitomo Dainippon Pharma
Curated by ChEMBL
Affinity DataIC50: 157nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium mobilization...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Sumitomo Dainippon Pharma
Curated by ChEMBL
Sumitomo Dainippon Pharma
Curated by ChEMBL
Affinity DataIC50: 174nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium mobilization...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Sumitomo Dainippon Pharma
Curated by ChEMBL
Sumitomo Dainippon Pharma
Curated by ChEMBL
Affinity DataIC50: 177nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium mobilization...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Sumitomo Dainippon Pharma
Curated by ChEMBL
Sumitomo Dainippon Pharma
Curated by ChEMBL
Affinity DataIC50: 237nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium mobilization...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Sumitomo Dainippon Pharma
Curated by ChEMBL
Sumitomo Dainippon Pharma
Curated by ChEMBL
Affinity DataIC50: 403nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium mobilization...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sumitomo Dainippon Pharma
Curated by ChEMBL
Sumitomo Dainippon Pharma
Curated by ChEMBL
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP2A6 in human liver microsomes using coumarin as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sumitomo Dainippon Pharma
Curated by ChEMBL
Sumitomo Dainippon Pharma
Curated by ChEMBL
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of CYP2A6 in human liver microsomes using coumarin as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of TYK2 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2A6 in human liver microsomes using coumarin as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sumitomo Dainippon Pharma
Curated by ChEMBL
Sumitomo Dainippon Pharma
Curated by ChEMBL
Affinity DataIC50: 6.40E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sumitomo Dainippon Pharma
Curated by ChEMBL
Sumitomo Dainippon Pharma
Curated by ChEMBL
Affinity DataIC50: 7.40E+4nMAssay Description:Inhibition of CYP2A6 in human liver microsomes using coumarin as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
